Bioengineering in the oral cavity: our experience

Catalfamo, Luciano; Belli, Emrè; Nava, C; Mici, Elidon; Calvo, Ángel; D'Alessandro, B; Ponte, Francesco Saverio De

doi:10.2147/ijn.s47697

Cited by 6 publications

(1 citation statement)

References 17 publications

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“…Clinical trials using HA-based materials alone or with cellular components have been performed in the attempt to obtain a regenerative action mainly as wound healing and osteo-articular repair. Indeed, most of these studies underlined the benefits that the HA derivatives, either as hydrogel or solid mesh, exerted in human diseases such as venous ulcers [ 107 ],[ 108 ], decubitus ulcers [ 109 ], oral mucosal lesions [ 110 ], surgical ablation of nevi/cutaneous tumors and cicatritial outcomes [ 111 ], talar dome and knee osteochondral lesions [ 112 ],[ 113 ], and cranial bone regeneration [ 114 ]. So far, no clinical trial started to verify whether such biomaterial can be useful also to repair the infarcted myocardium.…”

Section: Discussionmentioning

confidence: 99%

Hyaluronan and cardiac regeneration

et al. 2014

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Hyaluronan (HA) is abundantly expressed in several human tissues and a variety of roles for HA has been highlighted. Particularly relevant for tissue repair, HA is actively produced during tissue injury, as widely evidenced in wound healing investigations. In the heart HA is involved in physiological functions, such as cardiac development during embryogenesis, and in pathological conditions including atherosclerosis and myocardial infarction. Moreover, owing to its relevant biological properties, HA has been widely used as a biomaterial for heart regeneration after a myocardial infarction. Indeed, HA and its derivatives are biodegradable and biocompatible, promote faster healing of injured tissues, and support cells in relevant processes including survival, proliferation, and differentiation. Injectable HA-based therapies for cardiovascular disease are gaining growing attention because of the benefits obtained in preclinical models of myocardial infarction. HA-based hydrogels, especially as a vehicle for stem cells, have been demonstrated to improve the process of cardiac repair by stimulating angiogenesis, reducing inflammation, and supporting local and grafted cells in their reparative functions. Solid-state HA-based scaffolds have been also investigated to produce constructs hosting mesenchymal stem cells or endothelial progenitor cells to be transplanted onto the infarcted surface of the heart. Finally, applying an ex-vivo mechanical stretching, stem cells grown in HA-based 3D scaffolds can further increase extracellular matrix production and proneness to differentiate into muscle phenotypes, thus suggesting a potential strategy to create a suitable engineered myocardial tissue for cardiac regeneration.Electronic supplementary materialThe online version of this article (doi:10.1186/s12929-014-0100-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Hyaluronan and cardiac regeneration

et al. 2014

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The hemostatic and comforting effects of oral adhesive bandages in tooth extraction: a randomized controlled clinical study

Zhou,

Cai,

Zhao

2024

Clin Oral Invest

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Objectives To compare oral adhesive bandages with the classic compression method and evaluate the clinical efficacy of this wound dressing material in improving postoperative comfort, wound healing, and hemostasis in tooth extraction. Materials and methods The study was designed as a randomized controlled clinical trial. A total of 120 patients were recruited and randomly assigned to the study group and the control group. In the study group, oral adhesive bandages were used as wound dressing. In the control group, patients bit on cotton balls and gauze, as usual. Hemorrhage, comfort, and healing levels were evaluated at postoperative 1 h, 24 h, and 7 days. The adhesion time of the oral adhesive bandages was also recorded. Results The average adhesion time of the oral adhesive bandages was 26.6 h. At postoperative 1 and 24 h, the hemostatic levels of the oral adhesive bandage group were significantly higher than those of the control group. The oral adhesive bandage group also reported significantly higher comfort scores than the control group. Both groups had similar healing levels and side effects. But the mean score for wound healing was slightly higher in the oral adhesive bandage group. Conclusions Oral adhesive bandages were more effective than cotton balls and gauze in providing hemostatic and comfort effects on extraction wounds. Clinical relevance Oral adhesive bandages possess clinical value in the management of extraction wounds.

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