Bioengineering exosomes for treatment of organ ischemia-reperfusion injury

M2 macrophage-derived exosome-encapsulated microneedles with mild photothermal therapy for accelerated diabetic wound healing

“…At present, exosome-based strategies still have limitations, such as a short half-lives and instability in vivo [ 14 ]. If free exosomes are injected directly at the wound site, it is difficult for them to remain at the site long enough to achieve satisfactory effects.…”

Advances in microRNA from adipose-derived mesenchymal stem cell-derived exosome: focusing on wound healing

“…50 Researchers have recently made significant advances in understanding the precise mechanisms by which ADMSC-Exo-miRNA contribute to inflammation, fibrosis, tissue regeneration, and angiogenesis. 19,50,51…”

“…Exos contain abundant miRNAs that are involved in various biological and regulatory processes, and these short RNAs are capable of controlling the function of the entire regulatory protein cascade that contributes to the phenotype of a cell. 50 Researchers have recently made significant advances in understanding the precise mechanisms by which ADMSC-Exo-miRNA contribute to inflammation, fibrosis, tissue regeneration, and angiogenesis. 19,50,51 2.1.…”

“…50 Researchers have recently made significant advances in understanding the precise mechanisms by which ADMSC-Exo-miRNA contribute to inflammation, fibrosis, tissue regeneration, and angiogenesis. 19,50,51 2.1. Characterization and biological function of Exo-miRNA MSC secrete a series of protective bioactive factors, namely the secretomes, which mainly contain growth factors, cytokines and extracellular vesicles (EVs) which includes Exo, microvesicle and apoptotic bodies.…”