Abstract:Steady state myoplasmic ion concentration and slow ion transport across the sarcolemma can be quantitatively studied by means of ion sensing electrodes (ISE). ISE's readout represents the sum of the electrochemical potential of the ion of interest and the resting membrane potential (Vm). Vm is measured either by using an independent standard microelectrode or a double-barreled capillary. These approaches have known limitations. Ion transport and membrane potential are intricately connected, the resting potenti… Show more
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