“…In 1907, Paul Ehrlich, whose work was related to the development of chemotherapy and specific targeted treatment concepts [54], introduced the term "magic bullet" as a drug specifically targeting a particular pathogen, without affecting the normal cells of the host, anticipating the era of the development of site-specific therapies for cancer treatment [55,56]. Today, the use of nanomedicine and nano(bio)technology in the BC field involves handling modern and challenging variants of Ehrlich s "magic bullet", which can be considered as nano-"magic bullets" that are able to perform multiple and targeted functions and tasks, such as different types of nanorobots/nanobots/nanovehicles/nanomachines/nanomotors/nanodevices or nanosubmarines/nanosubs [21,57], nanotrains [58], nanostars [59], enzymatic, magnetic or DNAzyme based nanoflowers/nanoclusters [60][61][62], urchin-head/hollow tail nanorobots with sharp nanospikes [12], nanospheres [63], nanocubes [64], nanorods [65], nanoneedles [66], nanotubes [67], worm-like nanocrystal micelles [68], nanoshells [43], nanosponges and nanokillers [47], nanoknives [69], nanoballons [70], nanozymes [71], nano-snowflakes [25], nanobubbles [72,73], nanoemulsions [74], nanobodies [75], nanobiosensors [76], nanopores [77], nanocages [33], nanotraps [34],or nanogenerators [78] (Figure 1). Undoubtedly, the use of nanoparticulate-based platforms has provide more and more advantages to the BC field including great biocompatibility and biodistibution, multifunctionality, the ability to overcome biological barriers and bioaccumulate in multiple tumor sites, even in the nucleus and specific organel...…”