2023
DOI: 10.1021/acsomega.3c07432
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Bioengineered Smart Nanocarriers for Breast Cancer Treatment: Adorned Carbon-Based Nanocomposites with Silver and Palladium Complexes for Efficient Drug Delivery

Moein Safarkhani,
Sadaf Saboori Moghaddam,
Fahimeh Taghavimandi
et al.

Abstract: Biocompatible and bioactive carbon-based nanocomposites are ingeniously designed and fabricated with the aim of enhancing drug delivery applicability in breast cancer treatment. Reduced graphene oxide (rGO) and multiwalled carbon nanotubes (MWCNTs) are utilized as nanocarriers for increasing penetrability into cells and the loading capacity. What sets our study apart is the strategic incorporation of the two different complexes of silver (AgL2) and palladium (PdL2) with the carboxamide-based ligand C9H7N3OS (L… Show more

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Cited by 2 publications
(2 citation statements)
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“…In 1907, Paul Ehrlich, whose work was related to the development of chemotherapy and specific targeted treatment concepts [54], introduced the term "magic bullet" as a drug specifically targeting a particular pathogen, without affecting the normal cells of the host, anticipating the era of the development of site-specific therapies for cancer treatment [55,56]. Today, the use of nanomedicine and nano(bio)technology in the BC field involves handling modern and challenging variants of Ehrlich s "magic bullet", which can be considered as nano-"magic bullets" that are able to perform multiple and targeted functions and tasks, such as different types of nanorobots/nanobots/nanovehicles/nanomachines/nanomotors/nanodevices or nanosubmarines/nanosubs [21,57], nanotrains [58], nanostars [59], enzymatic, magnetic or DNAzyme based nanoflowers/nanoclusters [60][61][62], urchin-head/hollow tail nanorobots with sharp nanospikes [12], nanospheres [63], nanocubes [64], nanorods [65], nanoneedles [66], nanotubes [67], worm-like nanocrystal micelles [68], nanoshells [43], nanosponges and nanokillers [47], nanoknives [69], nanoballons [70], nanozymes [71], nano-snowflakes [25], nanobubbles [72,73], nanoemulsions [74], nanobodies [75], nanobiosensors [76], nanopores [77], nanocages [33], nanotraps [34],or nanogenerators [78] (Figure 1). Undoubtedly, the use of nanoparticulate-based platforms has provide more and more advantages to the BC field including great biocompatibility and biodistibution, multifunctionality, the ability to overcome biological barriers and bioaccumulate in multiple tumor sites, even in the nucleus and specific organel...…”
Section: Nano-"magic Bullets" In Bc Theranosticsmentioning
confidence: 99%
See 1 more Smart Citation
“…In 1907, Paul Ehrlich, whose work was related to the development of chemotherapy and specific targeted treatment concepts [54], introduced the term "magic bullet" as a drug specifically targeting a particular pathogen, without affecting the normal cells of the host, anticipating the era of the development of site-specific therapies for cancer treatment [55,56]. Today, the use of nanomedicine and nano(bio)technology in the BC field involves handling modern and challenging variants of Ehrlich s "magic bullet", which can be considered as nano-"magic bullets" that are able to perform multiple and targeted functions and tasks, such as different types of nanorobots/nanobots/nanovehicles/nanomachines/nanomotors/nanodevices or nanosubmarines/nanosubs [21,57], nanotrains [58], nanostars [59], enzymatic, magnetic or DNAzyme based nanoflowers/nanoclusters [60][61][62], urchin-head/hollow tail nanorobots with sharp nanospikes [12], nanospheres [63], nanocubes [64], nanorods [65], nanoneedles [66], nanotubes [67], worm-like nanocrystal micelles [68], nanoshells [43], nanosponges and nanokillers [47], nanoknives [69], nanoballons [70], nanozymes [71], nano-snowflakes [25], nanobubbles [72,73], nanoemulsions [74], nanobodies [75], nanobiosensors [76], nanopores [77], nanocages [33], nanotraps [34],or nanogenerators [78] (Figure 1). Undoubtedly, the use of nanoparticulate-based platforms has provide more and more advantages to the BC field including great biocompatibility and biodistibution, multifunctionality, the ability to overcome biological barriers and bioaccumulate in multiple tumor sites, even in the nucleus and specific organel...…”
Section: Nano-"magic Bullets" In Bc Theranosticsmentioning
confidence: 99%
“…Nanoneedle-based platforms, functionalized with hyaluronic acid as the main extracellular matrix (ECM) component, and loaded with chemotherapeutic agents, are capable of overcoming biological barriers to penetrate tumors more rapidly and deliver drugs into the targeted organelles more efficiently [66]. Bioactive and biocompatible carbon-based nanocomposites have been ingeniously bioengineered as smart nano-carriers to enhance their loading capacity and penetrability into BC cells for BC therapy [67]. Parenteral administration of nanoemulsions can be principally applied to deliver chemotherapeutic substances to the BC TME [74].…”
Section: Nano-"magic Bullets" In Bc Theranosticsmentioning
confidence: 99%