2022
DOI: 10.3389/fbioe.2022.890479
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Bioengineered Probiotics: Synthetic Biology Can Provide Live Cell Therapeutics for the Treatment of Foodborne Diseases

Abstract: The rising prevalence of antibiotic resistant microbial pathogens presents an ominous health and economic challenge to modern society. The discovery and large-scale development of antibiotic drugs in previous decades was transformational, providing cheap, effective treatment for what would previously have been a lethal infection. As microbial strains resistant to many or even all antibiotic drug treatments have evolved, there is an urgent need for new drugs or antimicrobial treatments to control these pathogen… Show more

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Cited by 8 publications
(8 citation statements)
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References 212 publications
(230 reference statements)
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“…Indeed, the intragastric administration of Lactococcus lactis , which secrete IL-10, reduces or prevents the dextran sulfate sodium- (DSS) induced colitis in IL-10 deficient mice. Finally, it has been demonstrated that L. lactis that is secreting the LcrV protein ( Y. Pseudotuberculosis -protein) in a pseudotuberculosis mouse model has a protective role against the onset of colitis [ 101 , 102 , 103 ].…”
Section: Effect Of Probiotics and Prebiotics On The Intestinal Microb...mentioning
confidence: 99%
“…Indeed, the intragastric administration of Lactococcus lactis , which secrete IL-10, reduces or prevents the dextran sulfate sodium- (DSS) induced colitis in IL-10 deficient mice. Finally, it has been demonstrated that L. lactis that is secreting the LcrV protein ( Y. Pseudotuberculosis -protein) in a pseudotuberculosis mouse model has a protective role against the onset of colitis [ 101 , 102 , 103 ].…”
Section: Effect Of Probiotics and Prebiotics On The Intestinal Microb...mentioning
confidence: 99%
“…rhamnosus, Lcb. casei, and S. boulardii, either alone or together with antibiotic therapy, showed some treatment success in living models [112]. Today, there are studies on the creation of recombinant strains based on Lb.…”
Section: Recombinant Probiotics For the Treatment Of Infectious Disea...mentioning
confidence: 99%
“…The creation of a vaccine against Clostridium perfringens infection (the causative agent of necrotizing enterocolitis) and other gastrointestinal tract diseases is being considered. The need to create a vaccine against this pathogen is due to its resistance to standard antibiotics and the belief that vaccination is more effective [112]. Lcb.…”
Section: Vaccines Based On Recombinant Probiotics Against Bacterial P...mentioning
confidence: 99%
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