Bioengineered Magnetoferritin Nanoprobes for Single-Dose Nuclear-Magnetic Resonance Tumor Imaging

Zhao, Yanzhao; Liang, Minmin; Xiao, Li; Fan, Kelong; Xiao, Jie; Li, Yanli; Shi, Hongcheng; Wang, Fei; Choi, Hak; Cheng, Dengfeng; Yan, Xiyun

doi:10.1021/acsnano.5b07408

Cited by 82 publications

(73 citation statements)

References 51 publications

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“…Pharmacokinetics and biodistribution studies show a rapid clearance of Fe 3 O 4 nanozymes from the whole body and minimal exposure to healthy organs. Because Fe 3 O 4 and other iron oxide nanomaterials have been widely used for treating iron deficiency and as contrast agents for magnetic resonance imaging, [ 43,44 ] Fe 3 O 4 nanozyme lethality therefore holds a major promise for cancer treatment as a novel anticancer strategy.…”

Section: Discussionmentioning

confidence: 99%

Peroxidase‐Like Nanozymes Induce a Novel Form of Cell Death and Inhibit Tumor Growth In Vivo

Wang

Liu

et al. 2020

Adv Funct Materials

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Nanomaterials with intrinsic enzyme-like properties, termed nanozymes, have attracted significant interest, although limited information is available on their biological characteristics in cells or in vivo. Here, it is shown that nanomaterials with peroxidase-like activity trigger a novel form of cell death through an ATP-citrate lyase (ACLY)-dependent rat sarcoma viral oncogene (RAS) signaling mechanism. The peroxidase nanozyme-induced cell lethality, which is termed as nanoptosis, is morphologically and biochemically distinct from the currently well-defined apoptosis, necrosis, autophagy, pyroptosis, and ferroptosis. It is revealed that nanoptosis is typically characterized by the massive accumulation of cellular vesicles, swelling mitochondria, and distinct chromatin condensation and margination. Using RNA sequencing and protein quantitative mass spectrometry, an ACLY-dependent RAS signaling pathway is identified that mainly mediates this nanozyme lethality process, and it is observed that RAS-knockout cells are highly resistant to nanoptosis. Finally, it is demonstrated that this newly discovered nanozyme lethality can be used as an effective therapeutic strategy for inhibiting tumor growth in vivo.

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Section: Discussionmentioning

confidence: 99%

Peroxidase‐Like Nanozymes Induce a Novel Form of Cell Death and Inhibit Tumor Growth In Vivo

Wang

Liu

et al. 2020

Adv Funct Materials

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“…The size, structure, and physicochemical properties of nanocarriers are customizable, thus, suitable nanocarriers for targeted drug delivery may be designed for optimal treatment. Furthermore, nanocarriers can be designed to have different functions; for instance, ferritin nanocarriers can load iron oxide to bind transferrin receptor 1 (TfR1) over expressed on cancer cells for detection of tumors from clinical tissue specimens or for MR tumor imaging, as well as load anticancer drugs for cancer therapy…”

Section: Targeting Moieties On Nanocarriersmentioning

confidence: 99%

Ligand‐Installed Nanocarriers toward Precision Therapy

2019

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Development of drug‐delivery systems that selectively target neoplastic cells has been a major goal of nanomedicine. One major strategy for achieving this milestone is to install ligands on the surface of nanocarriers to enhance delivery to target tissues, as well as to enhance internalization of nanocarriers by target cells, which improves accuracy, efficacy, and ultimately enhances patient outcomes. Herein, recent advances regarding the development of ligand‐installed nanocarriers are introduced and the effect of their design on biological performance is discussed. Besides academic achievements, progress on ligand‐installed nanocarriers in clinical trials is presented, along with the challenges faced by these formulations. Lastly, the future perspectives of ligand‐installed nanocarriers are discussed, with particular emphasis on their potential for emerging precision therapies.

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“…Furthermore, ferritin-binding sites and the endocytosis of ferritin have been identified in tumor cells [22–25]. The association between ferritin and membrane-specific receptors lead the ferritin internalization to some tumor tissues [26].…”

Section: Ferritin Nanoparticles Used In Drug Deliverymentioning

confidence: 99%

Functional ferritin nanoparticles for biomedical applications

Wang

Gao

Zhang

et al. 2017

Front. Chem. Sci. Eng.

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Ferritin, a major iron storage protein with a hollow interior cavity, has been reported recently to play many important roles in biomedical and bioengineering applications. Owing to the unique architecture and surface properties, ferritin nanoparticles offer favorable characteristics and can be either genetically or chemically modified to impart functionalities to their surfaces, and therapeutics or probes can be encapsulated in their interiors by controlled and reversible assembly/disassembly. There has been an outburst of interest regarding the employment of functional ferritin nanoparticles in nanomedicine. This review will highlight the recent advances in ferritin nanoparticles for drug delivery, bioassay, and molecular imaging with a particular focus on their biomedical applications.

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Bioengineered Magnetoferritin Nanoprobes for Single-Dose Nuclear-Magnetic Resonance Tumor Imaging

Cited by 82 publications

References 51 publications

Peroxidase‐Like Nanozymes Induce a Novel Form of Cell Death and Inhibit Tumor Growth In Vivo

Peroxidase‐Like Nanozymes Induce a Novel Form of Cell Death and Inhibit Tumor Growth In Vivo

Ligand‐Installed Nanocarriers toward Precision Therapy

Functional ferritin nanoparticles for biomedical applications

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