Bioengineered blood vessels

Niu, Guoguang; Sapoznik, Etai; Söker, Shay

doi:10.1517/14712598.2014.880419

Cited by 23 publications

(27 citation statements)

References 86 publications

(22 reference statements)

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“…Polytetrafluoroethylene (PTFE) is a physiologically inert polymer widely used in industry and in many medical fields, such as mesh for hernia surgeries and vascular grafts [22][23][24]. Studies have reported the use of this material in dentistry as a way to reduce bacterial adhesion.…”

Section: Discussionmentioning

confidence: 99%

Alternative fixation system for implant-retained overdenture: case report

Valente

Castro

Bueno

et al. 2019

RGO, Rev. Gaúch. Odontol.

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The aim of this case report was to describe a prosthetic rehabilitation associated with an alternative model of polymer capsule for fixation system of implant-retained overdentures. Patient sought treatment at the clinic of School of Dentistry of Ribeirão Preto, due to lack of retention of their conventional total superior prostheses and inferior overdenture. The initial complaint was clinicallyconfirmed by altered intermaxillary relationships and severe reabsorption of the maxillary crest. In order to restore the function and improve its quality of life, it was proposed a prosthetic solution including implant fixed prosthesis to maxilla and a mandibular overdenture, with ball-type attachments associated with an alternative model of polymer capsule. This treatment was proposed inorder to reestablish the intermaxillary relationships and adequate occlusion, maintain retention and stability of the prosthesis. At the end of treatment and during a one-year follow-up of the case, the patient reported satisfaction and significant improvement in quality of life.

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Section: Discussionmentioning

confidence: 99%

Alternative fixation system for implant-retained overdenture: case report

Valente

Castro

Bueno

et al. 2019

RGO, Rev. Gaúch. Odontol.

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“…Tissue engineering in blood vessels (TEBV) still remains as a theory that is not fully developed for practical use 16 . Few case reports have shown applications of this technique in humans 17 .…”

Section: ■ Discussionmentioning

confidence: 99%

Ultrastructural analysis and residual DNA evaluation of rabbit vein scaffold

et al. 2017

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Purpose: To investigate the ultrastructural characteristics and analysis of residual DNA in scaffold models, produced with decellularized vena cava in an experimental model with rabbits. Methods: Three groups were created for ultrastructural and residual DNA analysis: group 1 -control, consisting of samples of vena cava in natura; group 2 -SD, consisting of vein fragments submitted to 2% sodium deoxycholate decellularization by shaking (160rpm -Shaker News Brunswick Scientific ® ) for 1 hour at controlled temperature shaker at 37°C; group 3 -SDS, consisting of vein fragments submitted to 1% sodium dodecyl sulfate decellularization under the same previous condition, for 2 hours. Results: The ultrastructural matrix of the blood vessel maintained its vintegrity after either decellularization models. The results of the two quantification methods demonstrated a significant decrease in the DNA content of the decellularized vena cava samples as compared to the control samples and, differed statistically from each other, p <0.05. Conclusion: The 2% DS protocol for vein decellularization, in this experimental model, was considered the best protocol because it presented less amount of residual DNA without causing substantial destruction of the extracellular matrix.

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“…When the release of VEGF was confirmed the particles were taken up for tissue culture study. For setting up the experiment, standard techniques were followed [ 16 , 17 ]. The experiments were setup in a vertical sandwich technique inside microfluidic chips.…”

Section: Methodsmentioning

confidence: 99%

A novel targeted angiogenesis technique using VEGF conjugated magnetic nanoparticles and in-vitro endothelial barrier crossing

Arokiaraj

2017

BMC Cardiovasc Disord

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BackgroundVascular endothelial growth factor is well known for its angiogenesis potential. The study was performed to determine the possible pro-angiogenic role of magnetic nanoparticles coupled to VEGF in vitro and their capacity to cross an endothelial monolayer. This novel treatment technique for angiogenesis could be potentially useful for therapeutic purposes using magnetic nanoparticles.MethodsMagnetic nanoparticles (MN) were synthesized and were conjugated with the vascular endothelial growth factor. The particles were tested in vitro in a 2D to 3D culture system. MN was seeded in different positions in relation to an HUVEC spheroid to assess a preferential migration.To evaluate the MN capacity to cross the endothelial barrier, a confluent monolayer of HUVEC cells was seeded on top of a collagen gel. MN was placed in dissolution on the cell culture media, and the MN position was determined by confocal microscopy for 24 h.ResultsHUVEC spheroids were able to generate a preferential sprouting depending on the MN position. Meanwhile, there was random migration when the MN’s were placed all over the collagen gel and no sprouting when no MN was added. The trans-endothelial migration capacity of the MN was observed after 20 h in culture in the absence of external stimuli.ConclusionHere we show in vitro angiogenesis following the distribution of the MN conjugated with growth factors. These nanoparticles could be controlled with a magnet to place them in the ischemic area of interest and speed up vascular recovery. Also, MN has potentials to cross endothelium, opening the doors to a possible intravascular and extravascular treatment.Electronic supplementary materialThe online version of this article (doi:10.1186/s12872-017-0643-x) contains supplementary material, which is available to authorized users.

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Bioengineered blood vessels

Cited by 23 publications

References 86 publications

Alternative fixation system for implant-retained overdenture: case report

Alternative fixation system for implant-retained overdenture: case report

Ultrastructural analysis and residual DNA evaluation of rabbit vein scaffold

A novel targeted angiogenesis technique using VEGF conjugated magnetic nanoparticles and in-vitro endothelial barrier crossing

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