Bioenergetics of growth, pregnancy and lactation in the laboratory mouse, Mus musculus

Studier, Eugene H.

doi:10.1016/0300-9629(79)90574-7

Cited by 24 publications

(11 citation statements)

References 50 publications

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“…; Randolph et al. ; Studier ; McClure and Randolph ; Mattingly and McClure ; Nicoll and Thompson ; Prentice and Whitehead ; Rose ; Weiner ). This lack of metabolic difference is likely due to the fact that all of the samples were collected post‐lactation, although it is interesting that we did not observe a change in baseline conditions across treatments as others have found (Zhang and Hood ).…”

Section: Discussionmentioning

confidence: 99%

Cellular metabolic rates and oxidative stress profiles in primary fibroblast cells isolated from virgin females, reproductively experienced females, and male Sprague-Dawley rats

2018

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Life‐history theory posits that differences in reproductive strategies may dictate lifespans of organisms. Animals that have higher investments in reproduction in terms of litter size and frequency of litters tend to have shorter lifespans. The accumulation of oxidative stress damage has been proposed to be a cost of reproduction and a mediator of life‐histories among animals, however, the implications of reproduction on oxidative stress still remain unclear. We tested physiological consequences of reproduction on metabolism and oxidative stress of Sprague‐Dawley Rats (Rattus norvegicus) with various reproductive experiences at the cell level. We grew primary dermal fibroblasts from Sprague‐Dawley rats which have the potential of having large litters frequently. Cells were isolated from virgin females, primiparous females, multiparous females, and reproductively‐experienced males. We measured basal oxygen consumption (OCR), proton leak, ATP production, spare respiratory capacity, coupling efficiency and glycolysis using a Seahorse XF96 oxygen flux analyzer. Additionally, we measured rates of RS (reactive species) production, reduced glutathione (GSH), mitochondrial content, and lipid peroxidation (LPO) damage to quantify oxidative stress. There were no significant differences in any OCR or glycolytic parameters across any of our groups. However, reproductively‐experienced females had significantly lower rates of LPO damage as compared with virgin females and males, as well as nonsignificant decreases in GSH concentration. Decreases in LPO damage and GSH indicate that reproductively‐experienced females potentially use their endogenous antioxidant system to combat delirious effects of increased metabolism during reproduction. Our results suggest that reproduction may, in fact, have a protective effect in females.

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Section: Discussionmentioning

confidence: 99%

Cellular metabolic rates and oxidative stress profiles in primary fibroblast cells isolated from virgin females, reproductively experienced females, and male Sprague-Dawley rats

2018

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“…data). All breeding mice have greatly increased demands for energy, protein and water, and when these resources are available ad libitum (as in laboratory conditions) they can allocate them directly to increasing litter size (Smith & McManus 1975;Studier 1979); but mice in field populations are usually fully exploiting the available resources, so must accommodate the additional demands of reproduction primarily by reallocation of resources from other functions . Therefore, it might be hypothesised that nutritional differences, shown in this study to dramatically affect juvenile growth rates, would also influence the number of females able to breed, their litter sizes and their ability to nurse young, and hence weaning success and body mass of weanlings.…”

Section: Discussionmentioning

confidence: 99%

Does high growth rate of juvenile house mice with prolonged access to ripening grain and free water drive population outbreaks?

Mutze¹

2007

New Zealand Journal of Zoology

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Post-weaning growth rates were measured for juvenile house mice (Mus domesticus) reared under four experimental treatments representing dietary conditions in cereal-growing areas of southeastern Australia. The mice were bred in captivity from adult wild mice captured in mature dry cereal crops during summer. Juvenile mice were caged in pairs at 23°C and offered a diet of either ripening wheat heads or mature dry wheat heads, with or without access to free water. All diets were adequate for survival, but juvenile mice on a diet of ripening wheat with water available grew at 0.25 g day -1 , 260% faster than those on a diet of mature wheat and deprived access to free water. Mice on a diet of ripening wheat but deprived of free water and those on a diet of mature wheat with water available grew at intermediate rates. Post-weaning growth rates of mice in all treatment groups were higher when the young were weaned at higher body mass. The results have implications for estimates of growth, timing of sexual maturity and reproduction of mice in field populations, and indicate that prolonged access to ripening grain and/or relief from moisture stress are likely to be critical to rapid population increase during population outbreaks.

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“…A value of 2 KJg Ϫ1 day Ϫ1 was chosen to represent the basal metabolic rate of the house mouse, averaged over an extensive dataset (Mychra et al 1969;Mychra 1975;Studier 1979;Bronson 1984;Stephenson and Malik 1984;Kö nig et al 1988;Manning and Bronson 1990;Mutze et al 1991;Hayes et al 1992;Hammond et al 1994;Richardson et al 1994). Half of this energy is used in essential service functions and the remaining half is available for cell maintenance functions.…”

Section: Model Parametersmentioning

confidence: 99%

Calorie Restriction and Aging: A Life-History Analysis

Shanley¹,

Kirkwood²

2000

Evolution

266

191

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Abstract. The disposable soma theory suggests that aging occurs because natural selection favors a strategy in which fewer resources are invested in somatic maintenance than are necessary for indefinite survival. However, laboratory rodents on calorie-restricted diets have extended life spans and retarded aging. One hypothesis is that this is an adaptive response involving a shift of resources during short periods of famine away from reproduction and toward increased somatic maintenance. The potential benefit is that the animal gains an increased chance of survival with a reduced intrinsic rate of senescence, thereby permitting reproductive value to be preserved for when the famine is over.We describe a mathematical life-history model of dynamic resource allocation that tests this idea. Senescence is modeled as a change in state that depends on the resources allocated to maintenance. Individuals are assumed to allocate the available resources to maximize the total number of descendants. The model shows that the evolutionary hypothesis is plausible and identifies two factors, both likely to exist, that favor this conclusion. These factors are that survival of juveniles is reduced during periods of famine and that the organism needs to pay an energetic ''overhead'' before any litter of offspring can be produced. If neither of these conditions holds, there is no evolutionary advantage to be gained from switching extra resources to maintenance. The model provides a basis to evaluate whether the life-extending effects of calorie-restriction might apply in other species, including humans.

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Bioenergetics of growth, pregnancy and lactation in the laboratory mouse, Mus musculus

Cited by 24 publications

References 50 publications

Cellular metabolic rates and oxidative stress profiles in primary fibroblast cells isolated from virgin females, reproductively experienced females, and male Sprague-Dawley rats

Cellular metabolic rates and oxidative stress profiles in primary fibroblast cells isolated from virgin females, reproductively experienced females, and male Sprague-Dawley rats

Does high growth rate of juvenile house mice with prolonged access to ripening grain and free water drive population outbreaks?

Calorie Restriction and Aging: A Life-History Analysis

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