Bioelements and Bioelementology in Pharmacology and Nutrition: Fundamental and Practical Aspects

Skalny, Anatoly V.

doi:10.5772/57368

Cited by 9 publications

(11 citation statements)

References 8 publications

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“…In the Biological System of the Elements described by Markertt et al [ 14 ], and Skalny [ 15 , 16 ], bioelements are divided into four categories: physiologically essential, electrolytic, enzymatic and exclusively toxic elements. Physiologically essential elements (C, H, O, Si, P, S, N, B, F, Rb, Sr, Ba, Ti, Al, Br, Cs, Ge, and Te) are important constituents of the functional molecular structural elements of the cell, such as proteins, lipids, carbohydrates, and nucleic acids.…”

Section: Introductionmentioning

confidence: 99%

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Changes in the bioelement content of summer and winter western honeybees (Apis mellifera) induced by Nosema ceranae infection

et al. 2018

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Proper bioelement content is crucial for the health and wellness of all organisms, including honeybees. However, the situation is more complicated in these important pollinators due to the fact that they change their physiology during winter in order to survive the relatively harsh climatic conditions. Additionally, honeybees are susceptible to many diseases such as nosemosis, which during winter can depopulate an entire colony. Here we show that summer bees have a markedly higher content of important bioelements such as: Al, Cu, P, V, (physiologically essential); Ca, K, Mg, (electrolytic); Cr, Se, Zn, (enzymatic); As, Hg, (toxic). In contrast, a markedly higher content of: Fe (physiologically essential); Mn, Ni, (enzymatic); Cd (exclusively toxic) were present in winter bees. Importantly, N. ceranae infection resulted in an increased honeybee bioelement content of: S, Sr (physiologically essential) and Pb (exclusively toxic), whereas the Nosema-free worker-bees had higher amounts of B and Si (physiologically essential). We propose that the shortages of Fe, Mn, Ni, and Na observed in Nosema-infected bees, could be the reason for the higher mortality of Nosema-infected bees throughout overwintering. In addition, a shortage of bioelements such as B and Si may be a reason for accelerated aging in foragers that is observed following N. ceranae infection. Therefore, in winter, bioelement content was more strongly affected by N. ceranae infection than during summer. We found a strong correlation between the bioelement content of bees and seasons (summer or winter) and also with Nosema infection. We conclude that the balance of bioelements in the honeybee is altered by both seasonal affects and by Nosema infection.

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Section: Introductionmentioning

confidence: 99%

“…Enzymatic elements (V, Cr, Mo, Mn, Fe, Co, Ni, Cu, Zn, Sn and Se), are mostly metal ions with catalytic functions in cell metabolism in the form of metal complexes. Exclusively toxic elements (Tl, Pb, Ga, Sb, In, Bi, Hg, and Cd) are lethal at low concentrations [ 14 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Changes in the bioelement content of summer and winter western honeybees (Apis mellifera) induced by Nosema ceranae infection

et al. 2018

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“…Ingestion of micronutrients and trace elements is considered an important factor for the maintenance of healthy life. Avoiding excess and deficiency of these elements is a matter of concern for humans and animals [1]. Iodine represents an essential micronutrient for performing thyroid functions which in turn controls all the body tissues metabolism including energy stores, body temperature and maintenance of body organs' functions [2,3].…”

Section: Introductionmentioning

confidence: 99%

Detection of some hormonal and enzymatic disorders associated to experimentally iodine induced hyperthyrodism.

Foda

Ibrahim

2021

Egypt. J. Chem.

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This study aimed to observe and report the status and the reaction of the body organs in case of administration of excess iodine. This was achieved by the intraperitoneal injection of KI for female mice. Results showed that the different organs respond to KI administration with different reactions. The thyroid gland expressed a gradual increase in serum thyroid hormones (T4&T3) which was accompanied with a detected significant decrease in serum TSH in addition to an observed histological changes in the thyroid tissue. Liver was the most apparent organ that was affected by excess KI administration followed by the brain through expressing increasing significant T3 levels in tissues compared to control. On the other hand, the heart and the kidneys tissues displayed non significant decrease in T3 levels. The study evaluated some tissue specific enzymes which showed significant biochemical abnormalities in organs' functions. Our data detected the features of a subclinical hyperthyroid case and express the initiation of an iodine induced hyperthyroidism pattern.

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“…In pregnancy, excessive exposure to heavy metals and some trace elements has been shown to be harmful to the developing fetus and may be harmful to the human nervous system, even at low levels [13] [14]. Also, several studies have reported that trace metals could easily cross the placenta and affect cognitive development [15] despite its function as a barrier protecting the fetus from toxic metal exposure.…”

Section: Introductionmentioning

confidence: 99%

Environmental Exposure to Lead, Vanadium, Copper and Selenium: Possible Implications in the Development of Autism Spectrum Disorders

Akinade¹,

Omotosho²,

Lagunju³

et al. 2019

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Human exposure to toxic metals is on the increase especially in the developing world; this is compounded by the almost unavoidable application of the metals domestically and industrially and their implication in several genetic defects, aging and some chronic illnesses including Autism Spectrum Disorders (ASD). This study investigated the concentration of toxic metals (Pb and V) and micro-essential elements (Cu and Se) in children with ASD and controls in Nigeria towards establishing their possible associations with the aetiopathogenesis of ASD. Eight children clinically diagnosed by Paediatric Neurologist and Child Psychiatrist for ASD using DMS-IV and fifteen apparently healthy children (age range 2-12 years) were recruited as cases and controls respectively. Plasma levels of Pb, V, Cu and Se were analyzed using Induction ICP-MS. Results were analyzed using students t-test. The mean plasma lead and vanadium levels were (7.92 ± 1.30 µg/dl; 1.07 ± 0.22 µg/dl) and (6.83 ± 0.72 µg/dl; 2.59 ± 0.48 µg/dl) in children with ASD and in controls respectively. The result showed that blood lead level in ASD was slightly increased but not significant when compared with control (p < 0.433). On the other hand, plasma vanadium concentration in ASD was significantly reduced (1.07 ± 0.22 µg/dl) when compared with control (2.59 ± 0.48 µg/dl) (P < 0.038). Mean plasma copper was similar in all participants (1.98 ± 0.13, 2.23 ± 0.12) but selenium concentrations were significantly reduced (0.37 ± 0.05 mg/L; 0.57 ± 0.02 mg/L) in ASD relative to controls respectively. Given the physiological functions of vanadium and selenium, the observed reduced levels of the two elements in children with ASD may account for the speech How to cite this paper: Akinade, A.O.,

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Bioelements and Bioelementology in Pharmacology and Nutrition: Fundamental and Practical Aspects

Cited by 9 publications

References 8 publications

Changes in the bioelement content of summer and winter western honeybees (Apis mellifera) induced by Nosema ceranae infection

Changes in the bioelement content of summer and winter western honeybees (Apis mellifera) induced by Nosema ceranae infection

Detection of some hormonal and enzymatic disorders associated to experimentally iodine induced hyperthyrodism.

Environmental Exposure to Lead, Vanadium, Copper and Selenium: Possible Implications in the Development of Autism Spectrum Disorders

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