Bioelectronics meets nanomedicine for cardiovascular implants: PEDOT-based nanocoatings for tissue regeneration

Karagkiozaki, V.; Karagiannidis, Panagiotis; Gioti, M.; Kavatzikidou, Paraskevi; Georgiou, D.; Georgaraki, E.; Logothetidis, S.

doi:10.1016/j.bbagen.2012.12.019

Cited by 61 publications

(51 citation statements)

References 45 publications

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“…These data are supported by previous reports demonstrating the non-toxic nature of both BC and PEDOT:PSS when cultured with animal cells on their own. For example, in addition to supporting fibroblast cell adhesion, PEDOT:PSS films were demonstrated to have little to no toxic effect on these cells (Karagkiozaki et al 2013). Moreover, the PEDOT:PSS silk composite used for biocompatible electrodes does not induce stress in the subjects (Tsukada et al 2012).…”

Section: Cytotoxicity Of Bc-pedot:pss Composite Filmmentioning

confidence: 96%

“…On its own, PEDOT was found to be highly biocompatible with epithelial, neural, and neuroblastoma cells, as well as cultured L929, NIH3T3 fibroblasts, and PC-12 cells (GuiseppiElie 2010). PEDOT has also been successfully incorporated in electronic ion pumps to deliver neurotransmitters in animal models and in organic electrochemical transistors for biosensing applications (Karagkiozaki et al 2013). Electroconductive and electrochemically switchable 3D-scaffolds have been fabricated by coating polyethylene terephthalate (PET) nanofibers with PEDOT:tosylate (PEDOT:TOS) to stimulate the proliferation of neuroblastoma cells (Bolin et al 2009).…”

Section: Electrical Conductivity Of Bc-pedot:pss Compositesmentioning

confidence: 99%

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Synthesis and characterization of a novel bacterial cellulose–poly(3,4-ethylenedioxythiophene)–poly(styrene sulfonate) composite for use in biomedical applications

et al. 2015

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This study explores the biocompatible behavior of bacterial cellulose (BC) composites with the highly conductive poly(3,4-ethylenedioxythiophene)-poly(styrene sulfonate) (PEDOT:PSS). To synthesize this novel composite, we utilized an ex situ penetration method, whereby never-dried BC sheets were incubated with aqueous PEDOT:PSS solution. The resulting composite films were characterized using several analytical tools. Field-emission scanning electron microscopy illustrated the impregnation of PEDOT:PSS into the BC matrix, while the uniform dispersion of PEDOT:PSS in the composites was confirmed with energy-dispersive X-ray spectroscopy. The conductivity of the PEDOT:PSS incorporated BC was 7.3 9 10 -2 ± 0.021 S/cm with 29.37 ± 2.13 weight percentage (wt%) of PED-OT:PSS. The biocompatibility of the BC-PED-OT:PSS film was tested against animal fibroblast cells. The composites showed excellent cell adhesion and proliferation. The animal cells showed filopodia formation and interconnectivity during 3 days of incubation. The cytotoxicity of the BC-PEDOT:PSS film was also assayed, confirming the non-toxic nature of this composite. Taken together, our results demonstrate that this novel biocompatible BC-PEDOT:PSS composite could potentially be used for biomedical applications, particularly in the biosensors, drug delivery devices, neural implants, and tissue engineering fields.

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Section: Cytotoxicity Of Bc-pedot:pss Composite Filmmentioning

confidence: 96%

Section: Electrical Conductivity Of Bc-pedot:pss Compositesmentioning

confidence: 99%

Synthesis and characterization of a novel bacterial cellulose–poly(3,4-ethylenedioxythiophene)–poly(styrene sulfonate) composite for use in biomedical applications

et al. 2015

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“…Optimizing the mechanical and electrical properties of polymer blends is a key requirement for these applications whilst providing essential physio-chemical and biological cues for cell 30 adhesion/proliferation and migration. Among conducting polymers, poly (3,4-ethylenedioxythiophene), PEDOT, with a balancing counter-ion, sodium polystryrenesulphonate, PSS, as dopant is a promising biocompatible material with good thermal, electrical and chemical stability [2][3][4][5] . However, a key disadvantage 35 in using PEDOT:PSS for biological applications is its inherent high Young's modulus and low ductility 6 .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a novel biomaterial with enhanced mechanical and conducting properties

et al. 2014

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5Conducting polymers combine the advantages of metal conductivity with ease in processing and biocompatibility; making them extremely versatile for biosensor and tissue engineering applications. However, the inherent brittle property of conducting polymers limits their direct use in such applications which generally warrant soft and flexible material responses. Addition of fillers increases the material compliance, but is achieved at the cost of reduced electrical conductivity. To retain suitable conductivity 10 without compromising the mechanical properties, we fabricate an electroactive blend (dPEDOT) using low grade PEDOT:PSS as the base conducting polymer with polyvinyl alcohol and glycerol as dopants. Bulk dPEDOT films show a thermally stable response till 110 ºC with over seven fold increase in room temperature conductivity as compared to 0.002 Scm -1 for pristine PEDOT:PSS. We characterized the nonlinear stress-strain response of dPEDOT, well described using a Mooney-Rivlin hyperelastic model, 15 with ductility of ~five times its original length and report elastomer-like moduli. Dynamic mechanical analysis shows constant storage moduli over a large range of frequencies with corresponding linear increase in tan (δ) values. We relate the enhanced performance of dPEDOT with the underlying structural constituents using FTIR and AFM microscopy. These data demonstrate specific interactions between individual components of dPEDOT, their effect on surface topography and material properties. Finally, 20 we show biocompatibility of dPEDOT using fibroblasts that have comparable cell morphologies and viability as control; making it attractive as a biomaterial. 65 Hookean (NH) form of hyperelastic constitutive model, given by = ( 1 2 + 2 2 + 3 2 − 3) where ; = 1: 3 are stretches in the principal directions respectively. These experimental data

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“…16 PEDOT coatings showed cytocompatibility and promoted human serum albumin adsorption and cell adhesion. 17 As a main strategy to synthesize PEDOT, electrochemical polymerization has numerous distinctive benets among the available routes, including lower quantities of required monomers, single stage preparation of conducting polymer layers, accessibility of characterization and ease of adjusting the thickness of the polymer coating. Gopi et al have synthesized PEDOT composite coatings on 316L SS implants through electrochemical route and the prepared coatings displayed promising result in in vitro biological studies.…”

Section: -9mentioning

confidence: 99%

Influence of surface treatment on PEDOT coatings: surface and electrochemical corrosion aspects of newly developed Ti alloy

et al. 2018

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Surface treatment of metallic materials prior to the application of polymer coatings plays an important role in providing improved surface features and enhanced corrosion protection. In the current investigation, we aimed to evaluate the effect of surface treatment of newly developed TiNbZr (TNZ) alloys on the surface characteristics, including the surface topography, morphology, hydrophobicity and adhesion strength of subsequent poly(3,4-ethylenedioxythiophene) (PEDOT) coatings. The surface morphology, chemical composition, and surface roughness of both treated and coated alloys were characterized by scanning electron microscopy, energy dispersive spectroscopy, and optical profilometry, respectively. The adhesion strength of the coating was measured using a micro scratch machine. Furthermore, we also evaluated the performance of electrochemically synthesized PEDOT coatings on surface-treated TNZ alloys in terms of the surface protective performance in simulated body fluid (SBF) and in vitro bioactivity in osteoblast MG63 cells. Surface analysis findings indicated that the nature of the PEDOT coating (surface morphology, topography, wettability and adhesion strength) was intensely altered, while the surface treatment performed before electrodeposition facilitated the overall performance of PEDOT coatings as implant coating materials. The obtained corrosion studies confirmed the enhanced corrosion protection performance of PEDOT coatings on treated TNZ substrates. In vitro cell culture studies validated the improved cell adhesion and proliferation rate, further highlighting the important role of surface treatment before electrodeposition.

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Bioelectronics meets nanomedicine for cardiovascular implants: PEDOT-based nanocoatings for tissue regeneration

Cited by 61 publications

References 45 publications

Synthesis and characterization of a novel bacterial cellulose–poly(3,4-ethylenedioxythiophene)–poly(styrene sulfonate) composite for use in biomedical applications

Synthesis and characterization of a novel bacterial cellulose–poly(3,4-ethylenedioxythiophene)–poly(styrene sulfonate) composite for use in biomedical applications

Fabrication of a novel biomaterial with enhanced mechanical and conducting properties

Influence of surface treatment on PEDOT coatings: surface and electrochemical corrosion aspects of newly developed Ti alloy

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