Bioelectronic tongue: Current status and perspectives

Wasilewski, T.; Kamysz, Wojciech; Gębicki, Jacek

doi:10.1016/j.bios.2019.111923

Cited by 48 publications

(37 citation statements)

References 168 publications

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“…These approaches are based on using multiple voltammetric signals and an advanced chemometric treatment to integrate the chemical information. [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] The first approach to quantify the DA levels in urine utilized a chemometric model (artificial neural network (ANN) [44] ) that was developed by using synthetic buffered samples containing DA, UA, and NE. The utilized ANN model resulted in a root mean square error (RMSE) value of 1.15 µm, a Pearson correlation coefficient (PCC) of 0.97, a LoD value of 4.2 µm, and a limit of quantification (LoQ) value of 13.9 µm; this indicates the feasibility of developing a chemometric model from synthetic samples and utilizing the model to predict DA levels in urine.…”

Section: Introductionmentioning

confidence: 99%

Partially Functional Electrode Modifications for Rapid Detection of Dopamine in Urine

Shukla

Aroosh

Matzafi

et al. 2021

Adv Funct Materials

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Designing functional materials as electrode coatings to transduce high-quality information about redox molecules in biofluids is crucial for developing the next-generation medical devices. Rapidly analyzing the neurotransmitter dopamine (DA) urinary levels can enable point-of-care testing for neuroendocrine tumors. A novel sensing electrodes array modified with biopolymer chitosan and electrocatalytic carbon nanotube films that can generate crossreactive electrochemical signals from complex biofluids, such as undiluted urine, is presented. By generating cross-reactive signals, the feasibility of quantifying DA levels from unprocessed urine samples is demonstrated. The films' electrochemical activity is characterized and modeled the additive effect of the main redox interferants in urine (norepinephrine and uric acid) on the generated electrochemical signals that overlap and mask the electrochemical signature of DA. Finally, the feasibility of successfully quantifying urinary DA levels is demonstrated by investigating two calibration approaches: 1) using a synthetic solution (1.15 µm root mean squared error (RMSE) and 4.2 µm limitof-detection (LoD) values), and 2) directly using the urine samples (2.5 µm RMSE and 9.3 µm LoD values). The outcome of this work will enhance the understanding of the overlapping and masking electrochemical signatures and their interactions with functional materials, providing better analytical tools to differentiate redox molecules in highly complex biofluids.

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Section: Introductionmentioning

confidence: 99%

Partially Functional Electrode Modifications for Rapid Detection of Dopamine in Urine

Shukla

Aroosh

Matzafi

et al. 2021

Adv Funct Materials

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“…In summary, the use of taste cells to develop biosensor systems for gustation is a new field with a wide range of possible applications [5][6][7]9,205]. Next-generation biosensor systems could now be developed with 3D taste cell cultures that can be used for both high-content imaging and live imaging microscopy.…”

Section: Development Of New In Vitro Taste Systemsmentioning

confidence: 99%

“…Since B-ETs are based on cells or tissues expressing taste receptors, they provide specificity, selectivity and sensitivity analogous to the biological sense of taste [5]. So far, transducers coupled to B-ETs use often voltametric/amperometric, potentiometric or piezoelectric methods and thus include microelectrode arrays, field effect transistors or light-addressable potentiometric sensors [5][6][7][8]. Even if these prototype devices have not yet been commercialized, B-ETs have a wide range of potential applications in the fields of drug and food industries, toxicology and biomedicine [3,9,10].…”

Section: Introductionmentioning

confidence: 99%

Sensing Senses: Optical Biosensors to Study Gustation

Molitor

Riedel

Hafner

et al. 2020

Sensors

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The five basic taste modalities, sweet, bitter, umami, salty and sour induce changes of Ca2+ levels, pH and/or membrane potential in taste cells of the tongue and/or in neurons that convey and decode gustatory signals to the brain. Optical biosensors, which can be either synthetic dyes or genetically encoded proteins whose fluorescence spectra depend on levels of Ca2+, pH or membrane potential, have been used in primary cells/tissues or in recombinant systems to study taste-related intra- and intercellular signaling mechanisms or to discover new ligands. Taste-evoked responses were measured by microscopy achieving high spatial and temporal resolution, while plate readers were employed for higher throughput screening. Here, these approaches making use of fluorescent optical biosensors to investigate specific taste-related questions or to screen new agonists/antagonists for the different taste modalities were reviewed systematically. Furthermore, in the context of recent developments in genetically encoded sensors, 3D cultures and imaging technologies, we propose new feasible approaches for studying taste physiology and for compound screening.

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“…The high costs of a new product (drug) development are explained not only by the expensive (bio)synthesis and purification of the reaction products, but also by the clinical trials, expensive monitoring systems, quality requirements, ethical concerns, and even featuring of taste and flavor properties of drug. Electrochemical MSAs, e-tongues and e-noses [ 229 , 230 ] have become good alternative methods used in the development and production of new pharmaceuticals, potentially replacing gas chromatography, HPLC, NMR, fluorescence, ELISA, human panels and animal models. Potentiometric e-tongues that are partially composed of ISEs with natural ionophores (valinomycin and nonactin [ 70 , 231 ]) and assisted by proteinase K demonstrated promising results in indirect monitoring of protein biosynthesis in bioreactors [ 232 ], protein purity control [ 233 ] and protein quantity evaluation [ 234 ].…”

Section: Application Of Msss and Msasmentioning

confidence: 99%

“…Similarly, bio-e-noses with olfactory receptors and olfactory cells were also applied in the evaluation of drug odor [ 6 ]. Very recently, several reviews on electrochemical e-tongues and e-noses in pharmaceutical manufacturing were published [ 229 , 230 , 238 , 239 , 240 ]. MSAs or e-tongues with the bioreceptors, suitable for studying the protein-protein, protein-drug, protein-nucleic acid, protein-lipid interactions, were not reported so far for pharmaceutical applications.…”

Section: Application Of Msss and Msasmentioning

confidence: 99%

Multisensor Systems and Arrays for Medical Applications Employing Naturally-Occurring Compounds and Materials

Pauliukaitė

Voitechovič

2020

Sensors

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The significant improvement of quality of life achieved over the last decades has stimulated the development of new approaches in medicine to take into account the personal needs of each patient. Precision medicine, providing healthcare customization, opens new horizons in the diagnosis, treatment and prevention of numerous diseases. As a consequence, there is a growing demand for novel analytical devices and methods capable of addressing the challenges of precision medicine. For example, various types of sensors or their arrays are highly suitable for simultaneous monitoring of multiple analytes in complex biological media in order to obtain more information about the health status of a patient or to follow the treatment process. Besides, the development of sustainable sensors based on natural chemicals allows reducing their environmental impact. This review is concerned with the application of such analytical platforms in various areas of medicine: analysis of body fluids, wearable sensors, drug manufacturing and screening. The importance and role of naturally-occurring compounds in the development of electrochemical multisensor systems and arrays are discussed.

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Bioelectronic tongue: Current status and perspectives

Cited by 48 publications

References 168 publications

Partially Functional Electrode Modifications for Rapid Detection of Dopamine in Urine

Partially Functional Electrode Modifications for Rapid Detection of Dopamine in Urine

Sensing Senses: Optical Biosensors to Study Gustation

Multisensor Systems and Arrays for Medical Applications Employing Naturally-Occurring Compounds and Materials

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