Bioelectronic multifunctional bone implants: recent trends

Santos, M.A.; Bernardo, Rodrigo

doi:10.1186/s42234-022-00097-9

Cited by 11 publications

(8 citation statements)

References 85 publications

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“…To achieve long-term device stability and fixation, tremendous efforts have been devoted to developing adhesion strategies optimized for flexible bioelectronics. [14][15][16] Conventional strategies, such as suturing, gluing, and the use of adhesive tapes, have been commonly used to secure flexible bioelectronics. However, these strategies are associated with critical drawbacks.…”

Section: Introductionmentioning

confidence: 99%

Conformal Fixation Strategies and Bioadhesives for Soft Bioelectronics

Park,

Kim,

Lim

et al. 2024

Adv Funct Materials

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Flexible wearable and implantable devices are contributing to the healthcare field by enabling intuitive interfaces with the tissues of human body through their thin form factors, which enable more accurate monitoring of signals and effective delivery of therapy. The development of such devices is accompanied with an increasing interest in strategies and technologies for conformally fixing and adhering flexible biomedical devices in place to acquire high‐quality biosignals over a long period, even with the subtle movements of the target. Owing to the various mechanical properties and wet or dynamic environments of human tissues, it is necessary to use different adhesion strategies that consider the biocompatibility and cohesive properties for each case. This paper provides an in‐depth analysis of recent bio‐adhesives technologies and their practical applications in the healthcare field by classifying them into: 1) Conventional Fixation, 2) Mechanical Fixation, and 3) Chemical Adhesion, based on the mechanism, and 4) Functional Adhesion and 5) Biomimetic Adhesion, based on the unique properties. Furthermore, the principles and detailed mechanisms of each adhesion strategy based on the design and characteristics of the bioadhesives are thoroughly reviewed to provide valuable insights and an overall summary of the prospects and challenges of future bioadhesives technology.

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Section: Introductionmentioning

confidence: 99%

Conformal Fixation Strategies and Bioadhesives for Soft Bioelectronics

Park,

Kim,

Lim

et al. 2024

Adv Funct Materials

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“…[40][41][42] Multifunctional smart implants, acting on bone-implant interfaces and with the ability to deliver personalized electromagnetic stimuli, may ultimately control bone regrowth and optimize osseointegration, thus reducing the incidence of revision surgeries. [37,[43][44][45] Three methods have been used to provide electromagnetic stimulation, which includes the delivery of electrical fields (EF) and magnetic fields (MF). Direct electric current (DC) stimulation, requiring direct contact of the cathode with injured bone tissues or bone cell cultures used as research models, has been widely studied for bone healing.…”

Section: Introductionmentioning

confidence: 99%

“…[ 40–42 ] Multifunctional smart implants, acting on bone‐implant interfaces and with the ability to deliver personalized electromagnetic stimuli, may ultimately control bone regrowth and optimize osseointegration, thus reducing the incidence of revision surgeries. [ 37,43–45 ]…”

Section: Introductionmentioning

confidence: 99%

Gathering Evidence to Leverage Musculoskeletal Magnetic Stimulation Towards Clinical Applicability

Figueiredo,

de Sousa,

Soares dos Santos

et al. 2024

Small Science

Self Cite

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Musculoskeletal disorders are among the main causes of disease‐associated disability. Moreover, the incidence and prevalence of osteoporosis and osteoarthritis, as well as the risk of bone fractures and the need for joint replacements, are expected to increase with longer life expectancy. New approaches based on electromagnetic stimulation have been developed, aiming to shorten bone healing time, attenuate osteoporosis and osteoarthritis, and increase implants' osseointegration. Inductive coupling (IC), a non‐invasive methodology to deliver magnetic stimuli, has reached clinical trials and some clinical practices but is not yet considered a standard procedure. Indeed, its feasibility in clinical use is still under discussion, and optimal stimulation parameters are fairly undefined. This comprehensive review describes the research trends and applicability of IC‐based therapeutics for musculoskeletal disorders, and starts identifying top‐performing magnetic stimulation parameters. Insights into the magnetic stimuli setups that promote osteogenesis are provided, based on pre‐clinical and clinical evidence from 117 in vivo studies in animal models and human patients. Potential cellular and molecular biomechanisms mediating IC‐induced effects on osteoblasts and osteoclasts are also explored. The transversal knowledge herein delivered will hopefully support innovative designs and medical devices that will implement IC stimulation as a clinical standard and effective therapeutic for musculoskeletal disorders.

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“…An emerging trend aims to design smart bioelectronic multifunctional implants incorporating bone–implant interface sensing systems, therapeutic actuation systems, processing systems, implant–clinician wireless communication systems and self-powering systems [29,30]. This new implant concept has not yet been developed to minimize the burden of bone fracture management, namely by monitoring and accelerating the healing process.…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive capacitive sensing system for smart medical devices with ability to monitor fracture healing stages

Conceição

Completo

Santos

2023

J. R. Soc. Interface.

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Bone fractures are a global public health problem. A sustained increase in the number of incident cases has been observed in the last few decades, as well as the number of prevalent cases and the number of years lived with disability. Current monitoring techniques are based on imaging techniques, which are highly subjective, radioactive, expensive and unable to provide daily monitoring of fracture healing stages. The development of reliable, non-invasive and non-subjective technologies is mandatory to minimize non-union risks. Delayed healing and non-union conditions require timely medical intervention, such that preventive procedures and shortened treatment periods can be carried out. This work proposes the development of an ultrasensitive capacitive sensing system for smart implantable fixation implants with ability to effectively monitor the evolution of bone fractures. Both in vitro experimental tests and numerical simulations highlight that networks of co-surface capacitive systems are able: (i) to detect four different bone healing phases, capacitance decrease patterns occurring as the healing process progresses and (ii) to monitor the callus evolution in multiple target regions. These are very promising results that highlight the potential of capacitive technologies to minimize the individual and social burdens related to fracture management, mainly when delayed healing or non-union conditions occur.

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Bioelectronic multifunctional bone implants: recent trends

Cited by 11 publications

References 85 publications

Conformal Fixation Strategies and Bioadhesives for Soft Bioelectronics

Conformal Fixation Strategies and Bioadhesives for Soft Bioelectronics

Gathering Evidence to Leverage Musculoskeletal Magnetic Stimulation Towards Clinical Applicability

Ultrasensitive capacitive sensing system for smart medical devices with ability to monitor fracture healing stages

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