Bioelectromagnetics in morphogenesis

Levin, Michael

doi:10.1002/bem.10104

Cited by 125 publications

(95 citation statements)

References 343 publications

(280 reference statements)

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“…However, the results obtained are contradictory and comparison between them is difficult (Berg 1999), because of the many differences in parameters (duration and periodicity of the exposure, flux intensity, endpoints investigated). Besides studies on teratogenesis (Levin 2003), tumor promotion (Lacy-Hulbert et al 1998) and hematology (Bonhomme-Faivre et al 1998, Ali et al 2003, several authors have examined the genotoxic properties of ELF magnetic fields. Some studies have been performed on samples taken from individuals professionally exposed.…”

Section: Introductionmentioning

confidence: 99%

Clastogenicity and aneuploidy in newborn and adult mice exposed to 50 Hz magnetic fields

Udroiu

Cristaldi

Ieradi

et al. 2006

International Journal of Radiation Biology

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Purpose: To detect possible clastogenic and aneugenic properties of a 50 Hz, 650 mT magnetic field. Materials and methods: The micronucleus test with CREST (Calcinosis, Raynaud's phenomenon, Esophageal dismotility, Sclerodactility, Telangectasia) antibody staining was performed on liver and peripheral blood sampled from newborn mice exposed to an ELF (Extremely Low Frequency) magnetic field during the whole intra-uterine life (21 days), and on bone marrow and peripheral blood sampled from adult mice exposed to the same magnetic field for the same period. Results: Data obtained in newborn mice show a significant increase in micronuclei frequencies. In absolute terms, most of the induced micronuclei were CREST-negative (i.e., formed by a chromosome fragment). However, in relative terms, ELF exposure caused a two-fold increase in CREST-negative micronuclei and a four-fold increase in CREST-positive micronuclei (i.e., formed by a whole chromosome). No significant effect was recorded on exposed adults. Conclusions: These findings suggest the need for investigation of aneugenic properties of ELF magnetic fields in order to establish a possible relationship to carcinogenesis.

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Section: Introductionmentioning

confidence: 99%

Clastogenicity and aneuploidy in newborn and adult mice exposed to 50 Hz magnetic fields

Udroiu

Cristaldi

Ieradi

et al. 2006

International Journal of Radiation Biology

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“…55,56 An electric field can be formed in a polarized cell membrane, which can influence the voltage and ion flux of the adjacent cells so that cells can act in correlation. [55][56][57] The conductivity of the scaffold facilitates such electrical communication among cells. Since ion flux of cells has influence on the general cell performances such as cell attachment, viability, and migration, it is expected that employing conductive scaffolds influences cell response and viability.…”

mentioning

confidence: 99%

3D conductive nanocomposite scaffold for bone tissue engineering

Shahini¹,

Yazdimamaghani²,

Walker³

et al. 2013

IJN

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Bone healing can be significantly expedited by applying electrical stimuli in the injured region. Therefore, a three-dimensional (3D) ceramic conductive tissue engineering scaffold for large bone defects that can locally deliver the electrical stimuli is highly desired. In the present study, 3D conductive scaffolds were prepared by employing a biocompatible conductive polymer, ie, poly(3,4-ethylenedioxythiophene) poly(4-styrene sulfonate) (PEDOT:PSS), in the optimized nanocomposite of gelatin and bioactive glass. For in vitro analysis, adult human mesenchymal stem cells were seeded in the scaffolds. Material characterizations using hydrogen-1 nuclear magnetic resonance, in vitro degradation, as well as thermal and mechanical analysis showed that incorporation of PEDOT:PSS increased the physiochemical stability of the composite, resulting in improved mechanical properties and biodegradation resistance. The outcomes indicate that PEDOT:PSS and polypeptide chains have close interaction, most likely by forming salt bridges between arginine side chains and sulfonate groups. The morphology of the scaffolds and cultured human mesenchymal stem cells were observed and analyzed via scanning electron microscope, micro-computed tomography, and confocal fluorescent microscope. Increasing the concentration of the conductive polymer in the scaffold enhanced the cell viability, indicating the improved microstructure of the scaffolds or boosted electrical signaling among cells. These results show that these conductive scaffolds are not only structurally more favorable for bone tissue engineering, but also can be a step forward in combining the tissue engineering techniques with the method of enhancing the bone healing by electrical stimuli.

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“…It is also known that HSCs migrate during embryonic development and early childhood; the migration of HSCs allows different sites to participate in hematopoiesis at different moments in life [184,185]. Importantly, numerous investigations have shown that ELF-EMFs can stimulate the division of stem cells and promote tissue regeneration [34,[186][187][188][189][190][191][192]. In addition, cell migration is regulated by physiological electric currents [123,[193][194][195], and ELF-EMFs are known to induce electric currents that can alter cell migration [34,88,191,192,[196][197][198].…”

Section: The Stem Cell Division Theory Of Cancer Provides a New Framementioning

confidence: 99%

The Stem Cell Division Theory of Cancer

López‐Lázaro

2017

Preprint

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All cancer registries constantly show striking differences in cancer incidence by age and among tissues. For example, lung cancer is diagnosed hundreds of times more often at age 70 than at age 20, and this cancer in nonsmokers occurs thousands of times more frequently than heart cancer in smokers. An analysis of these differences using basic concepts in cell biology indicates that cancer is the end-result of the accumulation of cell divisions in stem cells. In other words, the main determinant of carcinogenesis is the number of cell divisions that the DNA of a stem cell has accumulated in any type of cell from the zygote. Cell division, process by which a cell copies and separates its cellular components to finally split into two cells, is necessary to produce the large number of cells required for living. However, cell division can lead to a variety of cancer-promoting errors, such as mutations occurring during DNA replication, chromosome aberrations arising during mitosis, errors in the distribution of cell-fate determinants between the daughter cells, and failures to restore physical interactions with other tissue components. Some of these errors are spontaneous, others are promoted by endogenous DNA damage occurring during quiescence, and others are influenced by pathological and environmental factors. The cell divisions required for carcinogenesis are primarily caused by multiple local and systemic physiological signals rather than by errors in the DNA of the cells. As carcinogenesis progresses, the accumulation of DNA errors promotes cell division and eventually triggers cell division under permissive extracellular environments. The accumulation of cell divisions in stem cells drives not only the accumulation of the DNA alterations required for carcinogenesis, but also the formation and growth of the abnormal cell populations that characterize the disease. This model of carcinogenesis provides a new framework for understanding the disease and has important implications for cancer prevention and therapy.

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Bioelectromagnetics in morphogenesis

Cited by 125 publications

References 343 publications

Clastogenicity and aneuploidy in newborn and adult mice exposed to 50 Hz magnetic fields

Clastogenicity and aneuploidy in newborn and adult mice exposed to 50 Hz magnetic fields

3D conductive nanocomposite scaffold for bone tissue engineering

The Stem Cell Division Theory of Cancer

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