Bioelectrocatalysis by redox enzymes at modified electrodes

Scheller, Frieder W.; Wollenberger, Ulla; Lei, Chenghong; Jin, Wen; Ge, Bixia; Lehmann, Claudia; Lisdat, Fred; Fridman, V. A.

doi:10.1016/s1389-0352(01)00055-1

Cited by 72 publications

(42 citation statements)

References 35 publications

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“…Электрохимические методы позволяют исследовать не только редокс-потенциалы исследуемых белков, но и электрокаталитические процессы, а также влияние различных регуляторов, медиаторов или ингибиторов на такие процессы [11,12,20,21,35]. В наших экспериментах было исследовано влияние цитохрома b 5 …”

Section: исследование окислительно-восстановительных потенциалов гемоunclassified

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Protein-protein interactions of cytochromes P450 3A4 and 3A5 with their intermediate redox partners cytochromes

et al. 2014

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ВВЕДЕНИЕ. Цитохромы Р450, открытые в конце 1950-х [1], являются ключевыми ферментами метаболизма ксенобиотиков (различные экзогенные химические соединения, включая лекарственные препараты и пищевые добавки). Они участвуют в метаболизме ряда эндогенных соединений (жирные кислоты, эйкозаноиды, стероидные гормоны, витамин D, ретиноиды, желчные кислоты). Метаболизм чужеродных соединений, катализируемый цитохромами Р450, в ряде случаев приводит к образованию токсичных метаболитов, влияющих на генетические процессы и канцерогенез [2], что обуславливает их медицинскую значимость. 17* -адресат для переписки

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Section: исследование окислительно-восстановительных потенциалов гемоunclassified

“…Электрохимические методы могут быть применены для исследования образования продуктивных комплексов с реализацией каталитической функции [12,20,21].…”

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Protein-protein interactions of cytochromes P450 3A4 and 3A5 with their intermediate redox partners cytochromes

et al. 2014

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“…glycolysis or the citric acid cycle) and even in the regulation of gene expression, where so-called redox switches are involved [1]. Over the past decades electrochemistry has surrendered important information on the mechanisms, kinetics and thermodynamics of ET reactions in biological systems [2].…”

Section: Electron Transfer In Electrochemical Systemsmentioning

confidence: 99%

“…In other words, the redox proteins should have favorable orientations towards both the electrode and the enzyme, in order to guarantee effective electron shuttling for the protein electrochemistry and the coupled enzyme catalysis [1]. Most proposals have some degree of molecular organization.…”

Section: Tablementioning

confidence: 99%

Small electron-transfer proteins as mediators in enzymatic electrochemical biosensors

Silveira

Almeida

2013

Anal Bioanal Chem

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Electrochemical mediators transfer redox equivalents between the active sites of enzymes and electrodes and, in this way, trigger bioelectrocatalytic redox processes. This has been very useful in the development of the so-called second generation biosensors, where they are able to transduce the catalytic event into an electrical signal. Among other pre-requisites, redox mediators must be readily oxidized/reduced at the electrode surface and easily interact with the biorecognition component. Small chemical compounds (e.g. ferrocene derivatives, ruthenium or osmium complexes and viologens) are frequently used for this purpose, but lately, small redox proteins (e.g. horse heart cytochrome c) have also played the role of redox partners in biosensing applications. In general, the docking between two complementary proteins introduces a second level of selectivity to the biosensor and enlarges the list of compounds targeted for analysis. Moreover, electrochemical interferences are frequently minimized owing to the small overpotentials achieved. This paper aims to provide an overview of enzyme biosensors that are mediated by electron transfer proteins. The article begins with a few considerations on mediated electrochemistry in biosensing 2 systems and proceeds with a detailed description of relevant works concerning the cooperative use of redox enzymes and biological electron donors/acceptors.

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“…Bioelectronics is a rapidly growing field at the junction of chemistry, biochemistry and physics [1][2][3][4][5][6][7][8][9]. The 'bottom up' development of new biosensors is one of the principal components of this emergent subject area.…”

Section: Introductionmentioning

confidence: 99%

Modelling the Transport and Kinetics of Electroenzymes at the Electrode/Solution Interface

Lyons

2006

Sensors

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Abstract:The solution phase transport and direct electrode kinetics of electro-enzymes are described in terms of a simple model in which the steady state reaction/diffusion equation for enzyme is solved subject to physically realistic boundary conditions. Two physically realizable situations are described: the semi infinite and the membrane bounded case. Limiting expressions for the reaction flux are derived and the kinetic possibilities discussed geometrically in terms of kinetic case diagrams.

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Bioelectrocatalysis by redox enzymes at modified electrodes

Cited by 72 publications

References 35 publications

Protein-protein interactions of cytochromes P450 3A4 and 3A5 with their intermediate redox partners cytochromes

Protein-protein interactions of cytochromes P450 3A4 and 3A5 with their intermediate redox partners cytochromes

Small electron-transfer proteins as mediators in enzymatic electrochemical biosensors

Modelling the Transport and Kinetics of Electroenzymes at the Electrode/Solution Interface

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