Bioelectrical pathology of the breast; real-time diagnosis of malignancy by clinically calibrated impedance spectroscopy of freshly dissected tissue

Mahdavi, Reihane; Hosseinpour, Parisa; Abbasvandi, Fereshteh; Mehrvarz, Sajad; Yousefpour, Narges; Ataee, Hossein; Parniani, Mohammad; Mamdouh, Amir; Ghafari, Hadi; Abdolahad, Mohammad

doi:10.1016/j.bios.2020.112421

Cited by 25 publications

(23 citation statements)

References 11 publications

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“…Moreover, it is a quantitative and real-time technique with potentially lower costs than standard methods, rendering it more accessible for routine use. A recent study showed that impedimetric analysis of freshly dissected breast tissue had significant potential in malignancy diagnosis and, therefore, a direct clinical application [ 20 ]. In a step further towards in vivo applications, Yun et al proposed the electrochemical impedance spectroscopy-on-a-needle for the electrical discrimination of tissues as a profiling procedure prior to biopsy [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Electrical Impedance-Based Characterization of Hepatic Tissue with Early-Stage Fibrosis

et al. 2022

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Liver fibrosis is a key pathological precondition for hepatocellular carcinoma in which the severity is confidently correlated with liver cancer. Liver fibrosis, characterized by gradual cell loss and excessive extracellular matrix deposition, can be reverted if detected at the early stage. The gold standard for staging and diagnosis of liver fibrosis is undoubtedly biopsy. However, this technique needs careful sample preparation and expert analysis. In the present work, an ex vivo, minimally destructive, label-free characterization of liver biopsies is presented. Through a custom-made experimental setup, liver biopsies of bile-duct-ligated and sham-operated mice were measured at 8, 15, and 21 days after the procedure. Changes in impedance were observed with the progression of fibrosis, and through data fitting, tissue biopsies were approximated to an equivalent RC circuit model. The model was validated by means of 3D hepatic cell culture measurement, in which the capacitive part of impedance was proportionally associated with cell number and the resistive one was proportionally associated with the extracellular matrix. While the sham-operated samples presented a decrease in resistance with time, the bile-duct-ligated ones exhibited an increase in this parameter with the evolution of fibrosis. Moreover, since the largest difference in resistance between healthy and fibrotic tissue, of around 2 kΩ, was found at 8 days, this method presents great potential for the study of fibrotic tissue at early stages. Our data point out the great potential of exploiting the proposed needle setup in clinical applications.

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Section: Discussionmentioning

confidence: 99%

Electrical Impedance-Based Characterization of Hepatic Tissue with Early-Stage Fibrosis

et al. 2022

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“…BIS技术是向生物体注入安全的多频激励电流, 以一种低频到高频的扫频方式采集生物组织不同频率下的阻抗信息, 通过提取频谱中有效的电学参数来定量分析生物组织的电学特性 [14] . BIS是能定量分析, 使用便捷及具有医学应用前景广泛的检测技术, 如Yao等 [15] 采用BIS技术对单细胞的电学特性与其结构之间的关系进行了研究, 根据细胞的单、双壳模型理论提出了不同种类细胞的电学模型; Mahdavi等 [16] 采用BIS技术对从乳腺癌手术中切割下来的新鲜组织进行阻抗的扫描和分析, 提出了一种新的乳腺病变病理评分的电学模型; Chen 等 [17] 从医学角度评价了BIS技术在乳腺癌保乳手术中对切缘肿瘤细胞是否残留进行快速定性的有效性, 其结果显示BIS检测的结果与冷冻切片活检的一致性较高, 对乳腺癌保乳手术中的切缘样本是否含有癌变组织的定性检测具有较高准确性, 可以适用于术中的快速判断. 此外BIS是功能性成像, 癌细胞相较于正常细胞有诸多的特性 [18] , 会产生与正常组织不同的电学信号, 因此可以用BIS 技术检测舌体中正常和癌变舌组织, 提取出两种组织的相异电学信息进而区分舌组织癌变区间.…”

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Tongue tumor tissue recognition based on bioelectrical impedance spectroscopy

南京大学医学院附属口腔医院¹,

南京航空航天大学²

2021

Acta Phys. Sin.

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“…Usually, the bioimpedance measured from below 1 kHz to around 1 MHz can be used to analyze the intracellular fluid and extracellular fluid, which may reflect the electrochemical changes in biological knee tissues 18 . The bioimpedance technique has been widely applied to clinical practices, such as evaluation of muscle injury severity level 19 , measurement of body composition 20,21 , monitoring venous ulcers 22 , obstetric anal sphincter injury diagnostics 23 , and diagnosis of breast tumor 24 . Based on the literature study, we hypothesize that the physical-chemical processes and tissue changes involved in knee injuries can induce a reduction of bioimpedance.…”

Section: Introductionmentioning

confidence: 99%

Bioimpedance Measurement of Knee Injuries using Bipolar Electrode Configuration

Ye¹,

Wu²,

Mao³

et al. 2021

Preprint

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Currently, there is no suitable solution for the point-of-care of knee injuries. A potential portable and low-cost technique for accessing and monitoring knee injuries is bioimpedance measurement. This study validated the feasibility of the bipolar electrode configuration for knee bioimpedance measurements with two electrodes placed on a fixed pair of knee acupuncture locations called Xiyan. Then, the study collected 82 valid samples to investigate the relationship between bioimpedance and knee injuries, among whom 45 patients, each with one healthy knee and one injured knee, and 37 individuals all with healthy knees. The self-contrast results indicated that knee injuries caused a reduction of bioimpedance of the knee by about 5% on average, which was detectable at around 100 kHz (p ≈ 0.001). Furthermore, the results analyzed by principal component analysis and support vector machines show that the detection sensitivity can reach 91.11% using the leave-one-out cross-validation.

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Bioelectrical pathology of the breast; real-time diagnosis of malignancy by clinically calibrated impedance spectroscopy of freshly dissected tissue

Cited by 25 publications

References 11 publications

Electrical Impedance-Based Characterization of Hepatic Tissue with Early-Stage Fibrosis

Electrical Impedance-Based Characterization of Hepatic Tissue with Early-Stage Fibrosis

Tongue tumor tissue recognition based on bioelectrical impedance spectroscopy

Bioimpedance Measurement of Knee Injuries using Bipolar Electrode Configuration

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