Bioelectric Stimulation of Bone Formation: Methods, Models, and Mechanisms

Spadaro, Joseph A.

doi:10.3109/15368378209040331

Cited by 21 publications

(5 citation statements)

References 36 publications

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“…It is not surprising that new skeletal tissue was found after DC administration. Many cases have been cited in the literature on electric field stimulation of cartilage and bone in vivo and in vitro (2)(3)(4)6,7,11,13,(19)(20)(21)(22). In addition, the importance of the nervous system in bone growth has been illustrated by the experiments of Bunch et al (5).…”

Section: Discussionmentioning

confidence: 99%

Response of amputated rat limbs to fetal nerve tissue implants and direct current

Sisken

Fowler

Romm

1984

Journal Orthopaedic Research

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We have previously shown that implanted fetal nerve tissue stimulates the regeneration of amputated chick limbs. The purpose of this study was to determine whether a similar phenomenon would occur in amputated rat limbs and if addition of applied direct current (DC) would affect this process. Thus, fetal nerve tissue was implanted into amputated stumps of 3-week-old rats; variable tissue regeneration was induced that was dependent on the age of the donor implant and the presence of applied DC. Twelve or 14 day fetal neural implants induced new accessory bones containing epiphyseal plates and marrow cavities and occasionally formed joint-like structures with the host humerus. Addition of DC to 12 day neural implants increased the number of new bones formed. Eighteen day neural tissue with applied DC did not induce new bone formation but stimulated the maximal elongation of the host humerus and outgrowth of nerve fibers to the cut surface. Implantation of fetal heart tissue or implantation of fetal neural tissue into unamputated limbs failed to induce new bone formation. Although true limb regeneration was not achieved, formation of new skeletal elements did occur and this effect was enhanced by applied DC.

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Section: Discussionmentioning

confidence: 99%

Response of amputated rat limbs to fetal nerve tissue implants and direct current

Sisken

Fowler

Romm

1984

Journal Orthopaedic Research

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“…A substantial volume of literature is available documenting the normal tissue response to osteochondral defects as well as responses following diverse forms of therapy (12,17,19,22,25,28,29). Recent advances in the efficacious demonstration of electrical stimulation in osteosynthesis (27) and chondrogenesis (6,20,23) prompted us to investigate the efficacy of such treatment in osteochondral defects as well.…”

mentioning

confidence: 99%

“…Recent advances in the efficacious demonstration of electrical stimulation in osteosynthesis (27) and chondrogenesis (6,20,23) prompted us to investigate the efficacy of such treatment in osteochondral defects as well.…”

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confidence: 99%

Pulsing direct current‐induced repair of articular cartilage in rabbit osteochondral defects

Lippiello

Chakkalakal

Connolly

1990

Journal Orthopaedic Research

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Osteochondral defects in the distal femoral condyles of rabbits exposed to a pulsing direct current exhibits an enhanced quality of repair. The signal, with a peak value of 2 microA repeating at 100 Hz, imposed an electric field in the tissue of 20-60 mV/cm2. Maximum efficacy was seen with a shorter period of exposure (40 vs. 160 h) initiated 48 h after surgery for 4 h/day. Repair tissue originated primarily from metaplasia of subchondral elements although hyperplasia of pre-existing chondrocytes at the margins of the defect could be detected. Defects in treated joints contained Safranin O staining material that was histologically similar to a disorganized hyaline cartilage. Central areas of the defects in control animals contained Safranin O-negative material that generally extruded over the surface as a pannus. The edges of nontreated defects also had characteristics of cartilaginous healing, stressing the importance of using serial sectioning techniques in this model of cartilage repair.

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“…The latter can be applied to the defect site non-invasively. The electric stimulation has been found to be particularly valuable to treat the difficult orthopaedic defects as delayed non-union and pseudarthrosis (Dealler, 1981;Spadaro, 1982. ) Bone formation was demonstrated by wrapping Teflon electret film around the femur of rabbit.…”

Section: E L E C T R I C Stimulation Of Bone Growthmentioning

confidence: 99%

Piezoelectric properties of biological polymers

Fukada

1983

Quart. Rev. Biophys.

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Piezoelectricity and pyroelectricity in wool and hair were observed by Martin early in 1941. The piezoelectric effect in wood was investigated in detail by Bazhenov (1961). Both converse and direct effect of shear piezoelectricity in wood was demonstrated by Fukada (1955). Bending piezoelectricity in bone was first discovered by Yasuda (1953). Shear and longitudinal piezoelectricity in bone and tendon was quantitatively investigatged by Fukada & Yasuda (1957, 1964).

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Bioelectric Stimulation of Bone Formation: Methods, Models, and Mechanisms

Cited by 21 publications

References 36 publications

Response of amputated rat limbs to fetal nerve tissue implants and direct current

Response of amputated rat limbs to fetal nerve tissue implants and direct current

Pulsing direct current‐induced repair of articular cartilage in rabbit osteochondral defects

Piezoelectric properties of biological polymers

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