Bioelectric potential gradients may initiate cell cycling: ELF and zeta potential gradients may mimic this effect

Ja, Beech

doi:10.1002/(sici)1521-186x(1997)18:5<341::aid-bem1>3.0.co;2-2

Cited by 16 publications

(11 citation statements)

References 92 publications

(7 reference statements)

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“…Electric field [208] Direct changes of specific transcriptional elements, 2nd messenger systems like NF-kB, differentiation, and cell cycle Ion-specific effects (K + and Clfluxes and pH) [102,[209][210][211][212][213][214][215][216] Fixed charges around cell surface control neoplasm Zeta potentials [217][218][219][220][221] The question of which aspect of ion flow is relevant in any instance of cell behavior is intimately tied to transduction mechanism: how does the cell (or a neighboring cell) know the membrane voltage has changed? Mechanisms that transduce electrical signal into second-messenger cascades [162] include those outlined in Table 1.…”

Section: Electroosmosismentioning

confidence: 91%

Role of Membrane Potential in the Regulation of Cell Proliferation and Differentiation

Sundelacruz

Levin

Kaplan

2009

Stem Cell Rev and Rep

414

386

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Biophysical signaling, an integral regulator of long-term cell behavior in both excitable and non-excitable cell types, offers enormous potential for modulation of important cell functions. Of particular interest to current regenerative medicine efforts, we review several examples that support the functional role of transmembrane potential (V(mem)) in the regulation of proliferation and differentiation. Interestingly, distinct V(mem) controls are found in many cancer cell and precursor cell systems, which are known for their proliferative and differentiation capacities, respectively. Collectively, the data demonstrate that bioelectric properties can serve as markers for cell characterization and can control cell mitotic activity, cell cycle progression, and differentiation. The ability to control cell functions by modulating bioelectric properties such as V(mem) would be an invaluable tool for directing stem cell behavior toward therapeutic goals. Biophysical properties of stem cells have only recently begun to be studied and are thus in need of further characterization. Understanding the molecular and mechanistic basis of biophysical regulation will point the way toward novel ways to rationally direct cell functions, allowing us to capitalize upon the potential of biophysical signaling for regenerative medicine and tissue engineering.

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Section: Electroosmosismentioning

confidence: 91%

Role of Membrane Potential in the Regulation of Cell Proliferation and Differentiation

Sundelacruz

Levin

Kaplan

2009

Stem Cell Rev and Rep

414

386

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“…Zeta potential is also associated with cancer; for example asbestos fibers and sheets of positively-charged materials (but not powders of the same material) induce tumors, probably by acting as a capacitor for bioelectric potential, the positive side corresponding to the electron sink existing at a wound (reviewed in [384]). In this section, we focus on depolarized V mem , which has been suggested to correspond to the cancer state [215,[385][386][387].…”

Section: A Unique Bioelectric Signature Reveals Incipient Cancermentioning

confidence: 99%

Cancer as a disorder of patterning information: computational and biophysical perspectives on the cancer problem

Moore

Walker

Levin

2017

Converg. Sci. Phys. Oncol.

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TOPICAL REVIEWCancer as a disorder of patterning information: computational and biophysical perspectives on the cancer problem IntroductionCancer is well-recognized not only as an extremely pernicious medical problem, but also as a group of phenomena deeply connected to the fundamental questions of evolution, multicellularity, pattern (disregulation, and the interplay between the genome and the environment [1,2]. Two fundamental paradigms currently divide the field. One is that cancer results from disorders of genetics: cancer cells are fundamentally broken due to genomic mutation or instability, and their clonal progeny form tumors and metastases. This view is sometimes called the SMT, somatic mutation theory [3][4][5]. A competing perspective is that of cancer as a circuit disease-a disorder of the complex biophysical, transcriptional, and epigenetic dynamics that regulate cellular state and the ability of cells to cooperate in vivo [6][7][8]. Under this view (sometimes called the tissue organization field theory or TOFT, [9,10]), cancer is akin to a traffic jam [11]-the problem is not a permanent discrete alteration within a founder cell and all of its clonal descendants, but an undesirable stable attractor in the complex network of controls that normally guides anatomical homeostasis [12].The relative merits of the two models have been discussed extensively [10,[13][14][15][16][17] AbstractThe current paradigm views cancer as arising clonally from a degradation of genetic information in single cells. A complementary perspective, originating at the dawn of modern developmental biology, is that cancer is the result of a system disorder of algorithms that normally orchestrate individual cell activities toward specific anatomical structures and away from tumorigenesis. A view of cancer as a disease of geometry focuses on the pathways that allow cells to cooperate to build and maintain large-scale anatomical patterning. Cancer may result when cells stop maintaining higher-order structures and reduce the boundary of their computational selves to a single-cell level, reverting to a unicellular lifestyle in which the rest of the organism is merely part of the environment at the expense of which all living things survive. While this view has been widely discussed, little progress has been made in providing a quantitative, mechanistic framework within which this perspective's specific and unique implications for treatment strategies can be tested and biomedically exploited. Here, we highlight two recent areas of progress which may facilitate much-needed progress on the cancer problem. First, we review the roles that endogenous bioelectrical networks, operating across many tissues in vivo, play as a medium of information processing in tumor suppression, progression, and reprogramming. Second, we provide a primer to the development of computational theory and tools for quantifying the information and causal control structures in cancer and other complex biological systems. Rigorous mathematical formalisms now exist to...

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“…[62] Evidence was also offered in support of an approach wherein the wound healing process could be assisted by endowing cells with relatively high ζ potentials. [63] Inorganic particles used as ingredients in skin care cosmetic products have been shown to accelerate skin permeability barrier recovery when they are provided with negative ζ potential values. [64] The sorption of nanoparticles applied for drug and gene delivery by the target cells can also be controlled using the ζ potential.…”

Section: Other Applications Of the Concept Of ζ; Potential In Biochemmentioning

confidence: 99%

Dynamic Light Scattering Based Microelectrophoresis: Main Prospects and Limitations

Uskoković¹

2012

Journal of Dispersion Science and Technology

125

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Microelectrophoresis based on the dynamic light scattering (DLS) effect has been a major tool for assessing and controlling the conditions for stability of colloidal systems. However, both the DLS methods for characterization of the hydrodynamic size of dispersed submicron particles and the theory behind the electrokinetic phenomena are associated with fundamental and practical approximations that limit their sensitivity and information output. Some of these fundamental limitations, including the spherical approximation of DLS measurements and an inability of microelectrophoretic analyses of colloidal systems to detect discrete charges and differ between differently charged particle surfaces due to rotational diffusion and particle orientation averaging, are revisited in this work. Along with that, the main prospects of these two analytical methods are mentioned. A detailed review of the role of zeta potential in processes of biochemical nature is given too. It is argued that although zeta potential has been used as one of the main parameters in controlling the stability of colloidal dispersions, its application potentials are much broader. Manipulating surface charges of interacting species in designing complex soft matter morphologies using the concept of zeta potential, intensively investigated recently, is given as one of the examples. Branching out from the field of colloid chemistry, DLS and zeta potential analyses are now increasingly finding application in drug delivery, biotechnologies, physical chemistry of nanoscale phenomena and other research fields that stand on the frontier of the contemporary science. Coupling the DLS-based microelectrophoretic systems with complementary characterization methods is mentioned as one of the prosperous paths for increasing the information output of these two analytical techniques.

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Bioelectric potential gradients may initiate cell cycling: ELF and zeta potential gradients may mimic this effect

Cited by 16 publications

References 92 publications

Role of Membrane Potential in the Regulation of Cell Proliferation and Differentiation

Role of Membrane Potential in the Regulation of Cell Proliferation and Differentiation

Cancer as a disorder of patterning information: computational and biophysical perspectives on the cancer problem

Dynamic Light Scattering Based Microelectrophoresis: Main Prospects and Limitations

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