Biodynamique des lipides: nouvelles perspectives

Selective mobilization of fatty acids from white fat cells: evidence for a relationship to the polarity of triacylglycerols

“…The widening in the range of the relative enrichment of fatty acids in polar TAGs compared with their relative mobilization rate (Figure 3) can be explained by the stringent separation of TAGs according to polarity. The substrate subjected to hydrolysis would be enriched in polar TAGs only, but not necessarily constituted exclusively of polar TAGs, as already suggested [34,37]. Therefore the relative enrichment of fatty acids in the most polar adipose tissue TAGs is consistent with their relative mobilization rates (i.e.…”

“…The physicochemical state of the substrate that could condition its availability has not been extensively studied during investigations into HSL substrate specificity. On the basis of their interactions with water, biologically active lipids have been classified according to physical properties and partition coefficients between several phases differing by their polarity [33,34]. It has been reported for lipoproteins that apolar lipids, mainly TAGs, enriched in polyunsaturated fatty acids have a higher partition coefficient between an interfacial phase and an apolar phase than TAGs enriched in saturated fatty acids [34].…”

“…On the basis of their interactions with water, biologically active lipids have been classified according to physical properties and partition coefficients between several phases differing by their polarity [33,34]. It has been reported for lipoproteins that apolar lipids, mainly TAGs, enriched in polyunsaturated fatty acids have a higher partition coefficient between an interfacial phase and an apolar phase than TAGs enriched in saturated fatty acids [34]. As a result, lipolytic enzymes would be more efficient towards TAGs enriched in polyunsaturated fatty acids.…”