Biodiversity of rodent anelloviruses in China

Du, Jie; Li, Yuhui; Lu, Liang; Zheng, Dan; Liu, Bo; Yang, Li; Su, Haoxiang; Dong, Jie; Sun, Lu; Zhu, Yafang; Yang, Jian; Yang, Fan; Xiao-bing, Zhang; Liu, Qiyong; Wú, Zhìqiáng; Jin, Qi

doi:10.1038/s41426-018-0037-x

Cited by 11 publications

(14 citation statements)

References 11 publications

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“…The core virome harbored by the rodent internal organs is quite different from the virome found in nasopharyngeal or rectal swabs previously [24,29,58,85,86]. The widely distributed RNA viruses, such as various PheVs, hepaciviruses, pegiviruses, and ArteVs detected in this study, were not or only occasionally found in the oral and anal samples previously described.…”

Section: Discussioncontrasting

confidence: 82%

“…But identification of novel viruses found in open environmental samples raises question of whether these viruses are harbored by the animal host and cause actual infections, or they are just viruses that infect insect, fungi, and plants (and other environmental sources) associated with the life habits of this animal host. Although our previous reports provided evolutionary evidence for the zoonotic origin of viruses such as henipavirus, HanV, AreV, SARS-CoV, and MERS-CoV [ 10 , 32 – 36 , 85 , 86 ], the presence of numerous vertebrate-irrelevant viral sequences in oral and rectal virome data complicated the definition of the host-virus relationships. Hence, organ- or tissue-based virome analysis, designated as “core virome” analysis, is also needed to accurately describe the viral infection status in natural reservoirs.…”

Section: Discussionmentioning

confidence: 97%

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Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia

et al. 2021

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Background As the largest group of mammalian species, which are also widely distributed all over the world, rodents are the natural reservoirs for many diverse zoonotic viruses. A comprehensive understanding of the core virome of diverse rodents should therefore assist in efforts to reduce the risk of future emergence or re-emergence of rodent-borne zoonotic pathogens. Results This study aimed to describe the viral range that could be detected in the lungs of rodents from Mainland Southeast Asia. Lung samples were collected from 3284 rodents and insectivores of the orders Rodentia, Scandentia, and Eulipotyphla in eighteen provinces of Thailand, Lao PDR, and Cambodia throughout 2006–2018. Meta-transcriptomic analysis was used to outline the unique spectral characteristics of the mammalian viruses within these lungs and the ecological and genetic imprints of the novel viruses. Many mammalian- or arthropod-related viruses from distinct evolutionary lineages were reported for the first time in these species, and viruses related to known pathogens were characterized for their genomic and evolutionary characteristics, host species, and locations. Conclusions These results expand our understanding of the core viromes of rodents and insectivores from Mainland Southeast Asia and suggest that a high diversity of viruses remains to be found in rodent species of this area. These findings, combined with our previous virome data from China, increase our knowledge of the viral community in wildlife and arthropod vectors in emerging disease hotspots of East and Southeast Asia.

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Section: Discussioncontrasting

confidence: 82%

Section: Discussionmentioning

confidence: 97%

Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia

et al. 2021

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“…The core virome harbored by the rodent internal organs is quite different from the virome found in nasopharyngeal or rectal swabs previously [24,27,56,82,83]. The widely distributed RNA viruses, such as various PheVs, hepaciviruses, pegiviruses, and ArteVs detected in this study, were not or only occasionally found in the oral and anal samples previously described.…”

Section: Discussioncontrasting

confidence: 82%

Decoding the RNA Viromes in Rodent Lungs Provides New Insight Into the Origin and Evolutionary Patterns of Rodent-borne Pathogens in Mainland Southeast Asia

Wu¹,

Han²,

Liu³

et al. 2020

Preprint

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BACKGROUND: As the largest group of mammalian species, which are also widely distributed all over the world, rodents are the natural reservoirs for many diverse zoonotic viruses. A comprehensive understanding of the core virome of diverse rodents should therefore assist in efforts to reduce the risk of future emergence or re-emergence of rodent-borne zoonotic pathogens. RESULTS: This study aimed to describe the viral range that could be detected in the lungs of rodents from Mainland Southeast Asia. Lung samples were collected from 3,284 rodents and insectivores of the orders Rodentia, Scandentia, and Eulipotyphla in eighteen provinces of Thailand, Lao PDR, and Cambodia throughout 2006-2018. Meta-transcriptomic analysis was used to outline the unique spectral characteristics of the mammalian viruses within these lungs and the ecological and genetic imprints of the novel viruses. Many mammalian- or arthropod-related viruses from distinct evolutionary lineages were reported for the first time in these species, and viruses related to known pathogens were characterized for their genomic and evolutionary characteristics, host species, and locations. CONCLUSIONS: These results expand our understanding of the core viromes of rodents and insectivores from Mainland Southeast Asia and suggest that a high diversity of viruses remains to be found in rodent species of this area. These findings, combined with our previous virome data from China, increase our knowledge of the viral community in wildlife and arthropod vectors in emerging disease hotspots of East and Southeast Asia.

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“…The core virome harbored by rodent internal organs is quite different from the virome found in nasopharyngeal and rectal swabs [20,25,54,79,80]. The widely distributed viruses such as various PheVs, hepaciviruses, pegiviruses, and ArteVs detected in this study were not or just occasionally found in oral and anal samples previously.…”

Section: Discussioncontrasting

confidence: 67%

Decoding the RNA viromes of rodent lungs provides new visions into the origin and evolution pattern of rodent-borne diseases in Mainland Southeast Asia

Wú¹,

Han²,

Liu³

et al. 2020

Preprint

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BACKGROUND As the largest group of mammalian species widely distributed all over the world, rodents are the natural reservoirs of diverse zoonotic viruses. Comprehensive understanding of the core virome in diverse rodent species could therefore assist efforts to predict and reduce the risk of future emergence or re-emergence of rodent-borne zoonotic pathogens. RESULTS This study aimed to describe the viral range detected in rodent lungs in Mainland Southeast Asia. Lung samples were collected from 3,284 rodents and insectivores of the orders Rodentia , Soricomorpha , Scandentia , and Erinaceomorpha in eighteen provinces of Thailand, Lao PDR, and Cambodia throughout 2006-2018. Meta-transcriptomic analysis was used to outline the unique spectral characteristics of mammalian viruses within lungs and the ecological and genetic imprints of novel viruses. Further analysis revealed that the viral circulation in lungs is vastly different from those of throat and anal swabs reported previously. Many mammal or arthropod related viruses with distinct evolutionary lineages were reported for the first time in these species, and viruses related to known pathogens were characterized for their genetic characters, host species, and locations. CONCLUSIONS These results expand our understanding of the core viromes of rodents and insectivores in Mainland Southeast Asia and suggest that a high diversity of viruses remain undiscovered in this area. These findings, combined with our previous virome data from China, increase our knowledge of the viral community in wildlife and arthropod vectors in emerging disease hotspots of East and Southeast Asia.

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Biodiversity of rodent anelloviruses in China

Cited by 11 publications

References 11 publications

Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia

Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia

Decoding the RNA Viromes in Rodent Lungs Provides New Insight Into the Origin and Evolutionary Patterns of Rodent-borne Pathogens in Mainland Southeast Asia

Decoding the RNA viromes of rodent lungs provides new visions into the origin and evolution pattern of rodent-borne diseases in Mainland Southeast Asia

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Biodiversity of rodent anelloviruses in China

Cited by 11 publications

References 11 publications

Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia

Decoding the RNA viromes in rodent lungs provides new insight into the origin and evolutionary patterns of rodent-borne pathogens in Mainland Southeast Asia

Decoding the RNA&nbsp;Viromes in Rodent Lungs Provides New Insight Into the Origin and Evolutionary Patterns of Rodent-borne Pathogens in Mainland Southeast Asia

Decoding the RNA viromes of rodent lungs provides new visions into the origin and evolution pattern of rodent-borne diseases in Mainland Southeast Asia

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Decoding the RNA Viromes in Rodent Lungs Provides New Insight Into the Origin and Evolutionary Patterns of Rodent-borne Pathogens in Mainland Southeast Asia