Biodistributions and Imaging of Poly(ethylene glycol)-Conjugated Silicon Quantum Dot Nanoparticles in Osteosarcoma Models via Intravenous and Intratumoral Injections
Guo Chen,
Lei Wang,
Pengbo He
et al.
Abstract:Osteosarcoma is a malignant tumor with relatively high
mortality
rates in children and adolescents. While nanoparticles have been widely
used in assisting the diagnosis and treatment of cancers, the biodistributions
of nanoparticles in osteosarcoma models have not been well studied.
Herein, we synthesize biocompatible and highly photoluminescent silicon
quantum dot nanoparticles (SiQDNPs) and investigate their biodistributions
in osteosarcoma mouse models after intravenous and intratumoral injections
by fluore… Show more
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