Biodistribution of the RD114/mammalian type D retrovirus receptor, RDR

Green, Bronwyn J.; Lee, C. Soon; Rasko, John E.J.

doi:10.1002/jgm.517

Cited by 36 publications

(26 citation statements)

References 59 publications

(78 reference statements)

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“…This strong conservation of ASCT2 receptor recognition throughout mammalian evolution (see also references 54 and 55) probably explains the susceptibility of various vertebrate species to ASCT2-mediated retroviral endogenization, a feature that is now extended to the xenarthran clade of placental mammals. Moreover, as similarly observed for the human, murine, bovine, monkey, and canine ASCT2 genes (54,(56)(57)(58), dasyASCT2 is widely expressed in several armadillo tissues, with its transcripts being detected in spleen, liver, kidney, muscle, and placenta (Fig. 2B).…”

Section: Discussionsupporting

confidence: 77%

Genome-Wide Screening of Retroviral Envelope Genes in the Nine-Banded Armadillo (Dasypus novemcinctus, Xenarthra) Reveals an Unfixed Chimeric Endogenous Betaretrovirus Using the ASCT2 Receptor

Malicorne

Vernochet

Cornelis

et al. 2016

J Virol

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Retroviruses enter host cells through the interaction of their envelope (Env) protein with a cell surface receptor, which triggers the fusion of viral and cellular membranes. The sodium-dependent neutral amino acid transporter ASCT2 is the common receptor of the large RD114 retrovirus interference group, whose members display frequent env recombination events. Germ line retrovirus infections have led to numerous inherited endogenous retroviruses (ERVs) in vertebrate genomes, which provide useful insights into the coevolutionary history of retroviruses and their hosts. Rare ERV-derived genes display conserved viral functions, as illustrated by the fusogenic syncytin env genes involved in placentation. Here, we searched for functional env genes in the nine-banded armadillo (Dasypus novemcinctus) genome and identified dasy-env1.1, which clusters with RD114 interference group env genes and with two syncytin genes sharing ASCT2 receptor usage. Using ex vivo pseudotyping and cell-cell fusion assays, we demonstrated that the Dasy-Env1.1 protein is fusogenic and can use both human and armadillo ASCT2s as receptors. This gammaretroviral env gene belongs to a provirus with betaretrovirus-like features, suggesting acquisition through recombination. Provirus insertion was found in several Dasypus species, where it has not reached fixation, whereas related family members integrated before diversification of the genus Dasypus >12 million years ago (Mya). This newly described ERV lineage is potentially useful as a population genetic marker. Our results extend the usage of ASCT2 as a retrovirus receptor to the mammalian clade Xenarthra and suggest that the acquisition of an ASCT2-interacting env gene is a major selective force driving the emergence of numerous chimeric viruses in vertebrates. IMPORTANCE Retroviral infection is initiated

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Section: Discussionsupporting

confidence: 77%

Genome-Wide Screening of Retroviral Envelope Genes in the Nine-Banded Armadillo (Dasypus novemcinctus, Xenarthra) Reveals an Unfixed Chimeric Endogenous Betaretrovirus Using the ASCT2 Receptor

Malicorne

Vernochet

Cornelis

et al. 2016

J Virol

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“…Using immunohistochemistry, ASCT2 was found only in regions where proximal tubules cells were present, i.e., in the inner and outer cortex, but not in the medulla (2). Human ASCT2 was found to have a moderate expression in kidney tubules (17). The expression of LAT2 transcript has been found to be restricted to the basolateral membrane of the renal proximal tubule (25).…”

Section: Discussionmentioning

confidence: 95%

High-salt intake and the renal expression of amino acid transporters in spontaneously hypertensive rats

Pinho

Serrão²,

Soares-da-Silva³

2007

American Journal of Physiology-Renal Physiology

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Pinho MJ, Serrão MP, Soares-da-Silva P. High-salt intake and the renal expression of amino acid transporters in spontaneously hypertensive rats. Am J Physiol Renal Physiol 292: F1452-F1463, 2007. First published January 30, 2007 doi:10.1152/ajprenal.00465.2006.-This study evaluated in spontaneously hypertensive rats (SHR) and WistarKyoto rats (WKY) the response to salt loading of the renal dopaminergic system and transcript abundance of Na ϩ -independent (LAT1 and LAT2) and Na ϩ -dependent (ASCT2 and B 0 AT1) amino acid transporters potentially involved in renal tubular uptake of L-DOPA. Rats were fed normal (NS)-or high (HS; 1% saline as drinking water)-salt intake for 24 h. Transcript abundance of amino acid transporters was age dependent, differently regulated in WKY and SHR and responded differently to salt intake. HS intake similarly increased urinary dopamine in 4-wk-old SHR and WKY. At 12 wk of age, HS intake increased urinary dopamine in SHR, but not in WKY. Changes in urinary dopamine paralleled changes in the uptake of L-DOPA in isolated renal tubules from 4-and 12-wk-old WKY and SHR on NS and HS intake. At 12 wk of age, HS intake was accompanied by decreases in LAT1 and LAT2 transcript abundance in WKY and SHR. ASCT2 and B 0 AT1 expression was significantly decreased in both 4-and 12-wk-old WKY and in 4-wk-old SHR on HS intake. By contrast, HS intake increased ASCT2 and B 0 AT1 expression in 12-wk-old SHR. It is concluded that salt-sensitive mechanisms influence LAT1, LAT2, ASCT2, and B 0 AT1 gene transcription. Differences in urinary dopamine and tubular uptake of L-DOPA between WKY and SHR during HS intake, namely in 12-wk-old animals, may result from increases in the ASCT2 and B 0 AT1 mRNA levels and less pronounced decreases in LAT2 expression.LAT2; ASCT2; B 0 AT1; kidney; hypertension THE OCCURRENCE OF HYPERTENSION in humans and laboratory animals is associated with the disruption of normal sodium excretion (7). During moderate salt intake, renal dopamine as a result of D 1 -like receptor activation is responsible for ϳ50% of the sodium excretion (19,37,50). Sodium transport is modulated by renal dopamine, which has its origin in renal proximal tubule (RPT) cells and has been shown to act as an autocrine/paracrine substance (50). Dopamine-induced natriuresis that results from the activation of dopamine D 1 -like receptors is associated with decreases in the activities of the Na ϩ -K ϩ -ATPase and the Na ϩ -H ϩ exchanger (10,15,29,35,63). On the other hand, sodium has been found to constitute an important stimulus for the production of dopamine by RPT cells (53,54,56), resulting in increases in the urinary excretion of dopamine and dopamine metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) (3,14,18,60,61).The spontaneously hypertensive rat (SHR) is the most used experimental model for naturally occurring hypertension, in which salt loading amplifies the structural and functional cardiac and renal changes associated with long-standing hypertension (12). In the SHR, dopa...

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“…57,58 The RDTR-LV transduction levels obtained for cytokine-stimulated hCD34 For personal use only. on May 11, 2018.…”

Section: Discussionmentioning

confidence: 99%

Baboon envelope pseudotyped LVs outperform VSV-G-LVs for gene transfer into early-cytokine-stimulated and resting HSCs

Girard-Gagnepain

Amirache

Costa

et al. 2014

Blood

121

142

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Biodistribution of the RD114/mammalian type D retrovirus receptor, RDR

Cited by 36 publications

References 59 publications

Genome-Wide Screening of Retroviral Envelope Genes in the Nine-Banded Armadillo (Dasypus novemcinctus, Xenarthra) Reveals an Unfixed Chimeric Endogenous Betaretrovirus Using the ASCT2 Receptor

Genome-Wide Screening of Retroviral Envelope Genes in the Nine-Banded Armadillo (Dasypus novemcinctus, Xenarthra) Reveals an Unfixed Chimeric Endogenous Betaretrovirus Using the ASCT2 Receptor

High-salt intake and the renal expression of amino acid transporters in spontaneously hypertensive rats

Baboon envelope pseudotyped LVs outperform VSV-G-LVs for gene transfer into early-cytokine-stimulated and resting HSCs

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