Biodistribution of Rhenium Cluster Complex K4[Re6S8(CN)6] in the Body of Laboratory Rats

Abstract

We studied the biodistribution of luminescent octahedral rhenium cluster complex K4[Re6S8(CN)6], a promising agent for photodynamic therapy. It was shown that rhenium complex [Re6S8(CN)6](4-)is mainly accumulated in the liver, the central organ of metabolism, and can be excreted by the kidneys. The cluster complex was also accumulated in the spleen in significant amount, which makes it a promising agent for creation of preparations for diagnostics and treatment of lymphoproliferative disorders. The mean lethal dose of the cluster complex was 0.38 g/kg.

Prospects of molybdenum and rhenium octahedral cluster complexes as X-ray contrast agents

“…It is clear that the cluster complex excreted through the kidneys rapidly. Earlier, we have demonstrated that cluster complex 1 can also be excreted through the kidneys, but in contrast to 8 is accumulated in the liver [38].…”

A comparative study of optical properties and X-ray induced luminescence of octahedral molybdenum and tungsten cluster complexes

“…Indeed, the family of octahedral cluster complexes [{Re 6 Q 8 }L 6 ] and [{Mo 6 X 8 }L 6 ] (where X is Cl, Br or I; Q is S, Se or Te and L are organic or inorganic ligands) and materials based on them have been intensively studied in the last few years in the context of biomedical applications. [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] First of all, this is due to the progress made in the develop-ment of phosphorescent octahedral molybdenum cluster complexes, all based on the {Mo 6 I 8 } 4+ cluster core that have particularly high quantum yields [34][35][36][37] and high efficiency in generating singlet oxygen. [38][39][40][41][42][43] Specifically, our recent studies have shown that materials doped using {Mo 6 I 8 } 4+ are highly photoluminescent and have low cellular toxicity in the dark, while by a careful selection of a matrix the cellular internalisation and photoinduced toxicity of the materials can be tuned.…”

A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes’ toxicity

“…Recent studies indicate that hexanuclear rhenium cluster complexes with the general formula [{Re 6 Q 8 }L 6 ] (where Q is S, Se, or Te and Ls are some organic or inorganic apical ligands) have high potential for therapeutic and diagnostic applications in different fields of biology and medicine due to their luminescence, photosensitising and antitumor properties as well as due to highly efficient absorption of X-rays. 1 – 13 This set of outstanding physical properties led to intensive studies of the biological properties of rhenium octahedral clusters. As an example, we have recently developed the cluster complex Na 2 H 8 [{Re 6 Se 8 }(P(C 2 H 4 CONH 2 )(C 2 H 4 COO) 2 ) 6 ] that demonstrated high radiodensity and high water solubility.…”