Biodistribution of colloidal gold nanoparticles after intravenous administration: Effect of particle size

Sonavane, Ganeshchandra S.; Tomoda, Keishiro; Makino, Kimiko

doi:10.1016/j.colsurfb.2008.07.004

Cited by 945 publications

(656 citation statements)

References 44 publications

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“…Nanoparticles are generally defined as particles between 1 and 50 nm in size. Studies have shown that the nanoscale objects smaller than 12 nm may cross the blood-brain barrier [1,2] and objects smaller than or equal to 30 nm may be endocytosed into cells. [3] It is not surprising that intensive research is carried out on biomedical applications of nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles and ions – friends or foes? As they are seen by human cells U-937 and HL-60

Barbasz

Oćwieja

2015

Journal of Experimental Nanoscience

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Gold nanoparticles (AuN) are one of the most investigated nanomaterials, finding numerous applications from medicine to industry. AuN were obtained by reduction of gold salts using tannic acid as a reducing agent. To detach the impact of AuN onto cells of two lines human monocytic cells (U-937) and human promyelocytic leukaemia cells (HL-60), the effects of postreaction residues (of effluent from sol cleaning) and gold ions were also examined. It was demonstrated that resistance of cells to the toxic action of AuN is dependent not only on incubation time and dosage, but also on stages of cell differentiation. It was found that after incubation of promonocytes U-937 with 25 ppm AuN, the cell viability decreased by 25% and of macrophages by 50%. Differentiated cells U-937 showed a significantly lower resistance than the not-differentiated cells. For HL-60 cells, regardless of differentiation, cell viability decreased by approximately 20% after treatment with 25 ppm AuN sol. It was noticed that U-937 exhibited higher vulnerability to AuN than HL-60 cells. It was proved that AuN induced over a 15-fold increase in nitric oxide and a decrease of intracellular glutathione levels indicating the inflammatory response of cells. Even though gold ions did not show a significant effect on cell viability, they caused fivefold increase of nitric oxide level. The results show a higher cytotoxicity of AuN than gold ions. An overall picture of the interaction of AuN with human cells of first defence line was obtained. The results indicate that AuN may cause changes in the response of phagocytes in inflammatory conditions.

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Section: Introductionmentioning

confidence: 99%

Gold nanoparticles and ions – friends or foes? As they are seen by human cells U-937 and HL-60

Barbasz

Oćwieja

2015

Journal of Experimental Nanoscience

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“…The determination of Au in the samples was carried out quantitatively by ICP-MS. The results revealed that the tissue distribution of Au NPs was size-dependent, with the smallest NPs (15 nm) showing the most widespread organ distribution [111]. Moreover, for all Au NP sizes the majority of the Au was demonstrated to be present in liver and spleen [112].…”

Section: Direct Inductively Coupled Plasma Mass Spectrometry Analysismentioning

confidence: 80%

“…Au, Ag and Cd) ensure a relatively low spectral background. Very recently, ICP-MS was used to study the biodistribution of Au NPs after intravenous administration in mice [111,112]. Au NPs of different sizes, mainly 15, 50, 100 and 200 nm, were synthesised.…”

Section: Direct Inductively Coupled Plasma Mass Spectrometry Analysismentioning

confidence: 99%

Inorganic mass spectrometry as a tool for characterisation at the nanoscale

et al. 2009

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Inorganic mass spectrometry techniques may offer great potential for the characterisation at the nanoscale, because they provide unique elemental information of great value for a better understanding of processes occurring at nanometre-length dimensions. Two main groups of techniques are reviewed: those allowing direct solid analysis with spatial resolution capabilities, i.e. lateral (imaging) and/or indepth profile, and those for the analysis of liquids containing colloids. In this context, the present capabilities of widespread elemental mass spectrometry techniques such as laser ablation coupled with inductively coupled plasma mass spectrometry (ICP-MS), glow discharge mass spectrometry and secondary ion/neutral mass spectrometry are described and compared through selected examples from various scientific fields. On the other hand, approaches for the characterisation (i.e. size, composition, presence of impurities, etc.) of colloidal solutions containing nanoparticles by the well-established ICP-MS technique are described. In this latter case, the capabilities derived from the on-line coupling of separation techniques such as field-flow fractionation and liquid chromatography with ICP-MS are also assessed. Finally, appealing trends using ICP-MS for bioassays with biomolecules labelled with nanoparticles are delineated.

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“…MUA-capped AuNPs are electrostatically stabilized due to the negative charge given by the deprotonated carboxylic groups. Therefore, MUAcapped AuNPs become unstable once the pH is decreased below its pKa, and the carboxylic groups subsequently protonated (an effective surface charge of > |30| mV is needed to keep NPs stable in solution following the DVLO theory [44]). On the other hand, the sterically stabilized NPs should be stable at any pH.…”

Section: Influence Of the Mixed Layer Composition And Conformation Onmentioning

confidence: 99%

The role of PEG conformation in mixed layers: from protein corona substrate to steric stabilization avoiding protein adsorption

Comenge¹

2015

ScienceOpen Research

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Although nanoparticles (NPs) have been traditionally modified with a single ligand layer, mixture of ligands might help to combine different functionalities and to further engineer the NP surface. A detailed study of the competition between an alkanethiol (11-mercaptoundecanoic acid) and SH-PEG for the surface of AuNPs and the resultant behaviors of this model nanoconjugate is presented here. As a result, the physicochemical properties of these conjugates can be progressively tuned by controlling the composition and especially the conformation of the mixed monolayer. This has implications in the physiological stability. The controlled changes on the SH-PEG conformation rather than its concentration induce a change in the stabilization mechanism from electrostatic repulsion to steric hindrance, which changes the biological fate of NPs. Importantly, the adsorption of proteins on the conjugates can be tailored by tuning the composition and conformation of the mixed layer.

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Biodistribution of colloidal gold nanoparticles after intravenous administration: Effect of particle size

Cited by 945 publications

References 44 publications

Gold nanoparticles and ions – friends or foes? As they are seen by human cells U-937 and HL-60

Gold nanoparticles and ions – friends or foes? As they are seen by human cells U-937 and HL-60

Inorganic mass spectrometry as a tool for characterisation at the nanoscale

The role of PEG conformation in mixed layers: from protein corona substrate to steric stabilization avoiding protein adsorption

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