Biodistribution of a Particulate Hepatolienographic CT Contrast Agent: A Study of Iodipamide Ethyl Ester in the Rat

Mr, Violante; Måre, Klas; Hw, Fischer

doi:10.1097/00004424-198101000-00008

Cited by 24 publications

(14 citation statements)

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“…Albumin coating also increases the accumulation of injected particles in the liver (8). The blood clearance of IDE particles is very rapid with most of the injected particles disappearing from the circulation during the first minutes after the injection (3,7). In this study we could not find any aggregates in pulmonary blood vessels, independent of their size.…”

Section: Discussioncontrasting

confidence: 45%

“…The swollen PMNs are jammed inthe small lung capillaries. The portion of the particles bypassing the lungs represents the vast majority of the injectd dose, since most of the particles are phagocytized by the RE cells of the liver and splee (7,9). We noticed in our previous work (3) that the PMN count drops significantly after an intravenous IDE particle injection, apparently due to sequestration of IDE-containing PMNs from the circulation.…”

Section: Lungsmentioning

confidence: 83%

“…The iodipamide ethyl ester particles (0.5-1.0 pm in diameter) were prepared in the University of Rochester (Rochester, New York, USA) using the method described in the literature (7).…”

Section: Parriclesmentioning

confidence: 99%

“…Particle aggregates in the plasma can embolize the lung capillaries after intravenous injection. The biodistribution of particulate IDE demonstrates that the initial high concentration in the lungs decreases almost as rapidly as in the blood (7). Thus most of IDE in the lung tissue appears to be situated freely in the capillaries shortly after injection.…”

mentioning

confidence: 99%

“…Thus most of IDE in the lung tissue appears to be situated freely in the capillaries shortly after injection. Most of the particles are subsequently ingested by the RE cells of the liver and spleen (7). We have studied the effect of the remaining small amount of IDE particles on the morphology of lungs, kidneys and blood using light and electron microscopy.…”

mentioning

confidence: 99%

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Accumulation and elimination of particulate iodipamide ethyl ester in the lungs and kidneys of the rat

Lauteala

Kormano

Violante

1988

APMIS

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Lauteala, L., Kormano, M. & Violante, M. R. Accumulation and elimination of particulate iodipamide ethyl ester in the lungs and kidneys of the rat. A morphological study. APMIS 96: 660-666, 1988.Particulate iodipamide ethyl ester, a new hepatolienographic x-ray contrast agent, was intravenously injected into rats. Lung and kidney biopsies taken at various intervals after the injection were examined by light and electron microscopy. IDE particles could be found in the lung capillaries phagocytized by polymorphonuclear neutrophils (PMNs). There were also free particles in the alveolar capillaries in the samples taken 5 min to 4 hours after the injection. No aggregates or emboli were seen. Two days or more after the injection no intra-and extracellular particles were present. The PMNs underwent transient local hydropic degeneration; the lung cells were morphologically intact. In the kidneys, the particles first appeared in both cortical and medullary capillaries. No emboli were observed. The kidney cells did not ingest IDE, but polymorphonuclear neutrophils (PMNs) with ingested IDE were often seen loosely attached to the glomerular capillary walls. In addition, free particles were evident in the capillaries in the samples taken up to 1 hour after injection. All particles in subsequent kidney samples were located in PMNs in the glomeruli. After three or more days the renal tissue was totally devoid of particulate IDE. No morphological evidence of kidney cell injury was observed.

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Section: Discussioncontrasting

confidence: 45%

Section: Lungsmentioning

confidence: 83%

“…The iodipamide ethyl ester particles (0.5-1.0 pm in diameter) were prepared in the University of Rochester (Rochester, New York, USA) using the method described in the literature (7).…”

Section: Parriclesmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Accumulation and elimination of particulate iodipamide ethyl ester in the lungs and kidneys of the rat

Lauteala

Kormano

Violante

1988

APMIS

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Diagnostic and Therapeutic Potential of Poly(benzyl L-glutamate)

Yang

Li²,

Nikiforow³

et al. 1994

Journal of Pharmaceutical Sciences

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Contrast Agents: X-ray Contrast Agents and Molecular Imaging – A Contradiction?

Speck¹

2008

Molecular Imaging I

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It is the purpose of this article to discuss whether and how X-ray contrast media may contribute to molecular imaging. X-ray contrast media are small molecules containing heavy elements, preferentially iodine. Modern CT allows precise, fast and reliable quantification of contrast media concentrations in large volumes with excellent spatial resolution throughout the body. The main disadvantage is the low contrast sensitivity requiring iodine concentrations of > or =0.5 mg/ml. Various approaches of the past and the present to specific contrast agents reflecting physiological, cellular or molecular processes are presented and options for the future are discussed.

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Biodistribution of a Particulate Hepatolienographic CT Contrast Agent: A Study of Iodipamide Ethyl Ester in the Rat

Cited by 24 publications

References 0 publications

Accumulation and elimination of particulate iodipamide ethyl ester in the lungs and kidneys of the rat

Accumulation and elimination of particulate iodipamide ethyl ester in the lungs and kidneys of the rat

Diagnostic and Therapeutic Potential of Poly(benzyl L-glutamate)

Contrast Agents: X-ray Contrast Agents and Molecular Imaging – A Contradiction?

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