Biodistribution characteristics of mannosylated, fucosylated, and galactosylated liposomes in mice

Intravenous administration of mannosylated cationic liposome/NFκB decoy complexes effectively prevent LPS‐induced cytokine production in a murine liver failure model

“…Recently we designed cholesten-5-yloxy-N-{4-[(1-imino-2-D Dthiomannosyl-ethyl)-amino]butyl} formamide (Man-C4-Chol) to prepare mannosylated cationic liposomes (Man-liposomes) for mannose receptor-mediated plasmid DNA (pDNA) delivery [20][21][22][23]. Man-C4-Chol can be stably incorporated into liposomes and easily recognized by mannose receptors under in vivo conditions [24]. Furthermore, because Man-C4-Chol has an amino group for binding to pDNA via electrostatic interaction and a mannose residue for recognition by mannose receptors, a high density of mannose residues can be provided on the surface of liposome without affecting the binding ability of the cationic liposomes to pDNA [20].…”

Liver Targeting Liposomes Containing .BETA.-Sitosterol Glucoside with Regard to Penetration-Enhancing Effect on HepG2 Cells.

“…They are biodegradable and have low toxicity because they consist of natural components of biomembranes such as phospholipids and cholesterol. As they can be modified with various kinds of ligand such as immunoglobulin, 1) protein 2) or sugar residues, 3,4) they can be used for drug targeting to specific sites and enhance the therapeutic effects by increasing drug association. We previously reported that drugs entrapped in liposomes modified with soybean-derived sterylglucoside (SG, SG-liposomes) accumulated in the liver, especially in hepatocytes, when administered to mice.…”

Glycosylation-mediated targeting of carriers

“…Mannose-containing phospholipids from the cell wall of mycobacteria [175] and synthetic mannosylated lipids [176][177][178][179][180][181][182][183][184][185][186][187][188][189][190][191] have been used to prepare mannosylated liposomes for drug delivery or imaging of macrophages and/or dendritic cells. formamide (Man-C4-Chol), a galactosylated cholesterol derivative, to prepare mannosylated liposomes [179].…”

“…formamide (Man-C4-Chol), a galactosylated cholesterol derivative, to prepare mannosylated liposomes [179]. To deliver drugs into macrophage-and/or dendritic cell in various tissues, we investigated various administration routes including intravenous [179,[192][193][194][195][196][197], intraperitoneal [198][199][200][201], and intratracheal [202,203] administration.…”

“…Fucose rectin is found exclusively in hepatic Kupffer cells [223]. We synthesized cholesten-5-yloxy-N-(4-((1-imino-2-D-thiofucosylethyl)amino)butyl)formamide, a fucosylated cholesterol derivative, to prepare the fucosylated liposomes [179].…”