Biodistribution and radioimmunopharmacokinetics of 131I-Ama monoclonal antibody in atherosclerotic rabbits

New Biochemical Insights into the Mechanisms of Pulmonary Arterial Hypertension in Humans

“…Although the origin of this metabolite in blood has not been well elucidated yet, aminomalonic acid can be routinely detected in the serum metabolome of healthy individuals by GC-MS [ 36 ]. Aminomalonic was first identified in human atherosclerotic plaques [ 37 ], and later was associated with the presence of foam cells and macrophage-rich tissues in atherosclerotic rabbits (aorta, blood, spleen, lungs) [ 38 ]. Besides, the origin of aminomalonic acid has been associated with free-radical mediated oxidation of amino acid residues in proteins, mainly glycine and cysteine [ 39 ].…”

Metabolomic study of plasma of patients with abdominal aortic aneurysm

“…In contrast, its presence in atherosclerotic plaque was described as early as 1984 [27]. Moreover, biodistribution studies of antibodies against aminomalonate injected in normal and hyperlipidemic rabbits revealed significantly greater staining for aminomalonate in atheromatous aortas than in normal aortas [28]. Its origin has, in addition, been attributed to radical-mediated oxidation of glycine [29], and it has recently been found to be reduced in the plasma of patients who have suffered from acute coronary syndrome [30].…”

Inflammation and Neovascularization Intertwined in Atherosclerosis

“…Their utility in humans remains largely unreported. For quantification of macrophage content, radiolabelled monoclonal antibody against amino malonic acid (AMA), a molecule vital to monocyte recruitment and foam cell production within atherosclerotic lesions, had significantly higher uptake in atheromatous aorta compared to normal aortas 44 . Slow radiotracer clearance from circulation however made in vivo imaging of aortic plaque unsuccessful.…”