Biodistribution and radiation dosimetry of [18F]F-PEB in nonhuman primates

Abstract

The effective radiation dose of [18F]F-PEB obtained from rhesus is similar to many other clinically utilized [18F] ligands.

Estimation of human effective absorbed dose of 67Ga–cDTPA–gonadorelin based on biodistribution rat data

“…Extrapolation between various animal species is more reliable than extrapolation between animals and humans [19], but earlier studies have shown the usefulness of using animal biodistribution as a model for absorbed dose estimations in humans [31][32][33][34]. Using physiological time extrapolation improves the mean result.…”

18F‐FPEB PET/CT Shows mGluR5 Upregulation in Parkinson's Disease

“…The difference between groups measured in this study was about 20%, which is encouraging. A delta of 20% is at least twofold higher than the coefficient of variation (CV) for [ 18 F]FPEB in the volumes of most potential interest, which tend to be less than 10%, and almost fourfold greater than the CV in the putamen, which is only about 5% …”

“…Fluorine‐18 ([ 18 F])‐3‐fluoro‐5‐[(pyridin‐3‐yl)ethynyl] benzonitrile ([ 18 F]FPEB) is one of several radiopharmaceuticals for noninvasively quantifying mGluR5 with positron emission tomography (PET) . [ 18 F]FPEB is a potent and highly specific antagonist . It has several characteristics shared by many useful biomarkers, including its relative ease of synthesis, physical half‐life, and a best‐in‐class kinetic energy associated with its positron.…”

Alternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaque

“…In terms of PET radiotracer development, agents targeting mGluR5 subtype have received the most attention . The most promising radiotracers include [ 18 F]‐FPEB, developed by Merck and [ 11 C]‐ABP688, a compound originally identified by Novartis (Figure ) . Recently, Wong et al .…”