Biodisposition and Histological Evaluation of Topically Applied Retinoic Acid in Liposomal, Cream and Gel Dosage Forms

Foong, W C; Harsanyi, B.B.; Mezei, Michael

doi:10.1007/978-1-4757-1364-0_25

Cited by 16 publications

(18 citation statements)

References 4 publications

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“…The study on liposomes for targeting drugs into the pilosebaceous units has suggested that liposomes are potent drug delivery systems for treating hair follicle-associated disorders, such as acne (Kumar & Katare, 2004;Yang et al, 2009). Incorporation of tretinoin in liposomes to overcome its problems has been studied by several researchers (Foong et al, 1990;Masini et al,1993;Patel et al, 2000;Brisaert et al, 2001;Sinico et al, 2005). It was previously found that liposomes can increase tretinoin concentration in the epidermis and dermis when compared to conventional cream or gel (Manconi et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients

et al. 2015

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Topical tretinoin is the most commonly used retinoid for acne. However, its irritative potential on the applied area and the barrier properties of the stratum corneum limit its use. The objective of the present study was to formulate tretinoin liposomal gel to obtain a formula with lower skin irritation potential and greater clinical effect. A statistical 2 4 factorial design was adopted. Sixteen formulae prepared and were properly evaluated. A candidate formula (F13G) prepared with 0.025% tretinoin, phospholipid-cholesterol-dicetylphosphate (9:1:0.01) and incorporated in 1% carbopol gel was selected for skin irritation test. Clinical study was conducted on acne patients and compared to marketed product. All liposomes formulations were spherical in shape. The addition of cholesterol in the film hydration method significantly decreased the vesicle size, and increased the percentage of incorporation efficiency at (p50.05). The presence of dicetylphosphate significantly increased drug release but did not affect the percentage of incorporation efficiency and vesicle size. The results of the clinical study in acne patients revealed that F13G showed significantly higher efficacy when compared to marketed product (p50.05).

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Section: Introductionmentioning

confidence: 99%

Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients

et al. 2015

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“…Foong et al [31] evaluated the biodisposition of tretinoin after its topical application in liposomal, cream and gel dosage forms. They found that liposomal formulations resulted in greater bioavailability with higher tretinoin concentration in the epidermis and upper dermis of guinea pigs than conventional formulations.…”

Section: Overview Of Various Novel Drug Delivery Strategiesmentioning

confidence: 99%

Novel Drug Delivery Systems: Potential in Improving Topical Delivery of Antiacne Agents

Date

Naik²,

Nagarsenker³

2005

Skin Pharmacol Physiol

106

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Acne is the most common cutaneous disorder of multifactorial origin with a prevalence of 70–85% in adolescents. The majority of the acne sufferers exhibit mild to moderate acne initially, which progresses to the severe form in certain cases. Topical therapy is employed as first-line treatment in mild acne, whereas for moderate and severe acne, systemic therapy is required in addition to topical therapy. Currently, several topical agents are available that affect at least one of the main pathogenetic factors responsible for the development of acne. Although topical therapy has an important position in acne treatment, side effects associated with various topical antiacne agents and the undesirable physicochemical characteristics of certain important agents like tretinoin and benzoyl peroxide affect their utility and patient compliance. Novel drug delivery strategies can play a pivotal role in improving the topical delivery of antiacne agents by enhancing their dermal localization with a concomitant reduction in their side effects. The current review emphasizes the potential of various novel drug delivery strategies like liposomes, niosomes, aspasomes, microsponges, microemulsions, hydrogels and solid lipid nanoparticles in optimizing and enhancing the topical delivery of antiacne agents.

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“…Other investigators have also suggested that the liposome formulations might localize entrapped medications in the skin [30][31][32]. In addition, Patel [33], reported that [ 3 H]-methotrexate entrapped in liposomes was retained in the skin of nude mice to an extent 2-3-fold greater than drug administered in the free state, and was associated with low concentrations of drug in the plasma and with sustained drug effects.…”

Section: Resultsmentioning

confidence: 95%

Cetirizine from topical phosphatidylcholine liposomes: Evaluation of peripheral antihistaminic activity and systemic absorption in a rabbit model

Elzainy

Simons

et al. 2004

Biopharm & Drug Disp

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This study was performed to assess the peripheral H(1)-antihistaminic activity and extent of systemic absorption of cetirizine from liposomes applied to the skin. Cetirizine was incorporated into small unilamellar vesicles (SUV) and multilamellar vesicles (MLV) prepared using L-alpha-phosphatidylcholine, and into Glaxal Base (GB), used as the control. In a randomized, cross-over study, each formulation, containing 10 mg of cetirizine, was applied to depilated areas on the backs of six rabbits (3.08+/-0.05 kg). Histamine-induced wheal tests and blood sampling were performed before cetirizine application and at designated times for up to 24 h. Compared with the baseline, histamine-induced wheal formation was suppressed by cetirizine in SUV and MLV from 0.5-24 h and by cetirizine in GB from 0.5-8 h, p

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Biodisposition and Histological Evaluation of Topically Applied Retinoic Acid in Liposomal, Cream and Gel Dosage Forms

Cited by 16 publications

References 4 publications

Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients

Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients

Novel Drug Delivery Systems: Potential in Improving Topical Delivery of Antiacne Agents

Cetirizine from topical phosphatidylcholine liposomes: Evaluation of peripheral antihistaminic activity and systemic absorption in a rabbit model

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