Biodemography of human ageing

Vaupel, James W.

doi:10.1038/nature08984

Cited by 877 publications

(631 citation statements)

References 75 publications

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“…Further, children born to parents of older ages are shown to suffer from many congenital diseases. It is uncertain that the progress made in saving lives is due to improved health in advanced age and, hence, an important topic for research (Vaupel 2010). Furthermore, there is a need to address not only the problems associated with reproduction at later ages and suggest potential remedies but also suggest possible ways of producing viable, healthy, and fertile progeny at older ages as offspring viability is shown to decline with increasing parental age in Drosophila (Hercus and Hoffmann 2000;Kern et al 2001).…”

Section: Drmentioning

confidence: 99%

Curcumin enhances parental reproductive lifespan and progeny viability in Drosophila melanogaster

Chandrashekara

Popli

Shakarad

2014

AGE

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Organismal lifespan is a complex trait that is governed by both its genetic makeup as well as the environmental conditions. The improved socioeconomic condition of humans has led to many lifestyle changes that in turn have altered the demography that includes postponement of procreation. Late age progeny is shown to suffer from many congenital diseases. Hence, there is a need to identify and evaluate natural molecules that could enhance reproductive health span. We have used the well-established model organism, Drosophila melanogaster, and ascertained the consequence of diet supplementation with curcumin. Flies reared on curcumin-supplemented diet had significantly higher lifespan. The progeny of flies reared on curcumin had a higher viability. The activity of a key mitochondrial enzyme-aconitase was significantly higher in flies reared on curcumin-supplemented diet. The results suggest that curcumin can not only correct a key step in the citric acid cycle and help in the release of additional energy but also permanently correct developmental and morphogenetic processes.

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Section: Drmentioning

confidence: 99%

Curcumin enhances parental reproductive lifespan and progeny viability in Drosophila melanogaster

Chandrashekara

Popli

Shakarad

2014

AGE

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“…Human lifespan and health span have risen significantly in recent decades (Vaupel, 2010). Yet, aging is a progressive and generalized deterioration of the functional capacities of an organism which strongly contributes to tissue failure.…”

Section: Introductionmentioning

confidence: 99%

The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon

et al. 2018

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SummaryCalorie restriction (CR) is an effective strategy to delay the onset and progression of aging phenotypes in a variety of organisms. Several molecular players are involved in the anti‐aging effects of CR, but mechanisms of regulation are poorly understood. Cellular senescence—a cellular state of irreversible growth arrest—is considered a basic mechanism of aging. Senescent cells accumulate with age and promote a number of age‐related pathologies. Whether environmental conditions such as diet affect the accumulation of cellular senescence with age is still unclear. Here, we show that a number of classical transcriptomic markers of senescent cells are reduced in adult but relatively young mice under CR. Moreover, we demonstrate that such senescence markers are not induced in the colon of middle‐age human volunteers under CR in comparison with age‐matched volunteers consuming normal Western diets. Our data support the idea that the improvement in health span observed in different organisms under CR might be partly due to a reduction in the number of senescent cells.

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“…Due to the decreased mortality in people over 80 (Kannisto 1994a;Kannisto et al 1994), life expectancy dramatically increased in Europe (Vaupel 1997(Vaupel , 2010Leon 2011) since about 1950, leading to a progressive raise of the oldest old (i.e. octogenarians, nonagenarians and centenarians).…”

Section: Introductionmentioning

confidence: 99%

Health status and 6 years survival of 552 90+ Italian sib-ships recruited within the EU Project GEHA (GEnetics of Healthy Ageing)

Cevenini¹,

Cotichini²,

Stazi³

et al. 2013

AGE

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In a scenario of increasing life expectancy worldwide, it is mandatory to identify the characteristics of a healthy aging phenotype, including survival predictors, and to disentangle those related to environment/ lifestyle versus those related to familiarity/genetics. To this aim we comprehensively characterised a cohort of 1,160 Italian subjects of 90 years and over (90+, mean age 93 years; age range 90-106 years) followed for 6 years survival, belonging to 552 sib-ships (familiar longevity) recruited (2005)(2006)(2007)(2008) within the EU-funded GEHA project in three Italian geographic areas (Northern, Central and Southern Italy) different for urban/rural and socio-economical characteristics. On the whole, the following factors emerged as significant predictors of survival after 90 years of age: absence of cognitive impairment and physical disability, high hand grip strength scores and body mass index (BMI) values, "excellent/good" self-reported health, high haemoglobin and total cholesterol levels and low creatinine levels. These parameters, excluding BMI values, were also significantly associated within sib-ships, suggesting a strong familial/genetic component. Geographical micro-heterogeneity of survival predictors emerged, such as functional and physical status being more important in Southern than in Central and Northern Italy. In conclusion, we identified modifiable survival predictors related to specific domains, whose role and importance vary according to the geographic area considered and which can help in interpreting the genetic results obtained by the GEHA project, whose major aim is the comprehensive evaluation of phenotypic and genetic data.

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Biodemography of human ageing

Cited by 877 publications

References 75 publications

Curcumin enhances parental reproductive lifespan and progeny viability in Drosophila melanogaster

Curcumin enhances parental reproductive lifespan and progeny viability in Drosophila melanogaster

The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon

Health status and 6 years survival of 552 90+ Italian sib-ships recruited within the EU Project GEHA (GEnetics of Healthy Ageing)

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