Biodelivery of nerve growth factor and gold nanoparticles encapsulated in chitosan nanoparticles for schwann-like cells differentiation of human adipose-derived stem cells

Razavi, Shahnaz; Seyedebrahimi, Reihaneh; Jahromi, Maliheh

doi:10.1016/j.bbrc.2019.03.189

Cited by 46 publications

(27 citation statements)

References 40 publications

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“…Chitosan, another widely used biodegradable and biocompatible polymer was used by Razavi et al (2019) to encapsulate NGF in chitosan nanoparticles (NGF-CNPs). NGF-CNPs were characterized by photon-correlation spectroscopy analysis, which showed a mean NGF-CSNP diameter of 147.04 ± 8.09 nm, and a good stability of the nanoparticle surface charge (36.47 ± 1.88 mV).…”

Section: Nanomedicines For Ngf Deliverymentioning

confidence: 99%

Nerve Growth Factor Biodelivery: A Limiting Step in Moving Toward Extensive Clinical Application?

et al. 2021

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Nerve growth factor (NGF) was the first-discovered member of the neurotrophin family, a class of bioactive molecules which exerts powerful biological effects on the CNS and other peripheral tissues, not only during development, but also during adulthood. While these molecules have long been regarded as potential drugs to combat acute and chronic neurodegenerative processes, as evidenced by the extensive data on their neuroprotective properties, their clinical application has been hindered by their unexpected side effects, as well as by difficulties in defining appropriate dosing and administration strategies. This paper reviews aspects related to the endogenous production of NGF in healthy and pathological conditions, along with conventional and biomaterial-assisted delivery strategies, in an attempt to clarify the impediments to the clinical application of this powerful molecule.

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Section: Nanomedicines For Ngf Deliverymentioning

confidence: 99%

Nerve Growth Factor Biodelivery: A Limiting Step in Moving Toward Extensive Clinical Application?

et al. 2021

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“…However, a color change to yellow and the singlet oxygen production were dramatically increased at pH 6.8, suggesting that pH e enables AuDD@CNf-Ce6 and AuDD/BSA@CNf-Ce6 to remove AuDD, followed by de-quenching and activation of Ce6. Emerging studies have suggested that the AuNP elicits thermogenesis owing to its strong absorption in the 808 nm region of NIR [28,36,37,44,45,46,47,48,49]. Furthermore, when the AuNP was released from AuDD/BSA@CNf-Ce6 at pH 6.8, we also examined how it has different photothermal effects in response to light (Figure 4).…”

Section: Resultsmentioning

confidence: 99%

“…The little red fluorescence from free Ce6 and Ce6-tagged AuNP was, however, detected because of their poor interaction with the cell membrane. Interestingly, BSA@CNf-Ce6 also showed strong red signals at pH 6.8, possibly because of its chitosan-based positive charge in acidic conditions and its filamentous shape [47].…”

Section: Resultsmentioning

confidence: 99%

Poisonous Caterpillar-Inspired Chitosan Nanofiber Enabling Dual Photothermal and Photodynamic Tumor Ablation

Park

Tran

et al. 2019

Pharmaceutics

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As caterpillars detect the presence of predators and secrete poison, herein, we show an innovative and highly effective cancer therapeutic system using biocompatible chitosan nanofiber (CNf) installed with a pH-responsive motif that senses tumor extracellular pH, pHe, prior to delivering dual-modal light-activatable materials for tumor reduction. The filamentous nanostructure of CNf is dynamic during cell interaction and durable in blood circulation. Due to its amine group, CNf uptakes a large amount of photothermal gold nanoparticles (AuNPs, >25 wt %) and photodynamic chlorin e6 (Ce6, >5 wt %). As the innovative CNf approaches tumors, cationic CNf effectively discharges AuNPs connected to the pH-responsive motif via electrostatic repulsion and selectively binds to tumor cells that are generally anionic, via the electrostatic attraction accompanied by CNf. We demonstrated via these actions that the endocytosed Ce6 (on CNf) and AuNPs (free from CNf) significantly elicited tumor cell death under light irradiation. As a result, the synergistic interplay of thermogenesis and photodynamic action was observed to switch on at the pHe, resulting in a striking reduction in tumor formation and growth rate upon light exposure.

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“…39 Moreover, Cui et al reported that the ALP levels and calcium nodule formation ability were significantly enhanced in NGF-treated BMSCs compared to untreated BMSCs, suggesting that NGF promotes the osteoblastic differentiation and mineralization capacities of BSMCs isolated from mice with diabetes. 40 In addition, NGF can reportedly induce the neurogenic differentiation of a variety of MSCs, including BMSCs, 41 ADSCs, 42 UCBMSCs, 43 and DPSCs, 44 in vitro. Moattari et al proposed using NGF-treated MSCs to repair peripheral nerve injuries in rats.…”

Section: Significance Statementmentioning

confidence: 99%

Nerve growth factor (NGF) and NGF receptors in mesenchymal stem/stromal cells: Impact on potential therapies

Zha

Tian

et al. 2021

Stem Cells Translational Medicine

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Mesenchymal stem/stromal cells (MSCs) are promising for the treatment of degenerative diseases and traumatic injuries. However, MSC engraftment is not always successful and requires a strong comprehension of the cytokines and their receptors that mediate the biological behaviors of MSCs. The effects of nerve growth factor (NGF) and its two receptors, TrkA and p75NTR, on neural cells are well studied. Increasing evidence shows that NGF, TrkA, and p75NTR are also involved in various aspects of MSC function, including their survival, growth, differentiation, and angiogenesis. The regulatory effect of NGF on MSCs is thought to be achieved mainly through its binding to TrkA. p75NTR, another receptor of NGF, is regarded as a novel surface marker of MSCs. This review provides an overview of advances in understanding the roles of NGF and its receptors in MSCs as well as the effects of MSC-derived NGF on other cell types, which will provide new insight for the optimization of MSC-based therapy.

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Biodelivery of nerve growth factor and gold nanoparticles encapsulated in chitosan nanoparticles for schwann-like cells differentiation of human adipose-derived stem cells

Cited by 46 publications

References 40 publications

Nerve Growth Factor Biodelivery: A Limiting Step in Moving Toward Extensive Clinical Application?

Nerve Growth Factor Biodelivery: A Limiting Step in Moving Toward Extensive Clinical Application?

Poisonous Caterpillar-Inspired Chitosan Nanofiber Enabling Dual Photothermal and Photodynamic Tumor Ablation

Nerve growth factor (NGF) and NGF receptors in mesenchymal stem/stromal cells: Impact on potential therapies

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