Biodegradation of tungsten embolisation coils used in children

Kampmann, Christoph; Brzezinska, Rita; Abidini, Moji; Wenzel, A; Wippermann, Carl-Friedrich; Habermehl, Pirmin; Knuf, Markus; Schumacher, R. A.

doi:10.1007/s00247-002-0825-1

Cited by 20 publications

(17 citation statements)

References 15 publications

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“…Note that we use much less tungsten in our foams (0.2 g for typical 8 mm foam sphere) than the average coils used by Kampmann et al . 27 and Saatci et al . 37 (12 g per coil, for a 0.25 mm DIA and 12.5 mm length of mechanically detachable spiral tungsten coils (MDSs)) and an average of 5 coils inserted per aneurysm.…”

Section: Discussionmentioning

confidence: 92%

Opacification of Shape Memory Polymer Foam Designed for Treatment of Intracranial Aneurysms

et al. 2011

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Shape memory polymer (SMP) foam possesses structural and mechanical characteristics that make them very promising as an alternative treatment for intracranial aneurysms. Our SMP foams have low densities, with porosities as high as 98.8%; favorable for catheter delivery and aneurysm filling, but unfavorable for attenuating X-rays. This lack of contrast impedes the progression of this material becoming a viable medical device. This paper reports on increasing radioopacity by incorporating a high-Z element, tungsten particulate filler to attenuate X-rays, while conserving similar physical properties of the original non-opacified SMP foams. The minimal amount of tungsten for visibility was determined and subsequently incorporated into SMP foams, which were then fabricated into samples of increasing thicknesses. These samples were imaged through a pig’s skull to demonstrate radio-opacity in situ. Quantification of the increase in image contrast was performed via image processing methods and standard curves were made for varying concentrations of tungsten doped solid and foam SMP. 4% by volume loading of tungsten incorporated into our SMP foams has proven to be an effective method for improving radio-opacity of this material while maintaining the mechanical, physical and chemical properties of the original formulation.

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Section: Discussionmentioning

confidence: 92%

Opacification of Shape Memory Polymer Foam Designed for Treatment of Intracranial Aneurysms

et al. 2011

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“…The implants should be flexible to be compatible with minimally invasive techniques, and sufficiently sturdy to prevent collapsing or kinking. The mechanical stability of resorbable polymeric materials is not satisfactory and their degradation can provoke inflammation, whereas with metal alloys superior mechanical strength can be achieved [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] . Whereas magnesium stents tend to degrade too rapidly, this appears not to be the case for iron implants [25][26][27][28][29][30][31] .…”

mentioning

confidence: 99%

Histological and molecular evaluation of iron as degradable medical implant material in a murine animal model

Mueller

Arnold

Badar

et al. 2012

J Biomedical Materials Res

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“…I read with interest the paper from Kampmann et al [1] on ''Biodegradation of tungsten embolisation coils used in children''. The authors imply that their work shows that corrosion of tungsten coils had previously only been demonstrated in vivo in the cerebral vasculature.…”

Section: Sirmentioning

confidence: 98%