Biodegradation of the X-ray contrast agent iopromide and the fluoroquinolone antibiotic ofloxacin by the white rot fungus Trametes versicolor in hospital wastewaters and identification of degradation products

Gros, Meritxell; Cruz-Morató, Carles; Marco‐Urrea, Ernest; Longrée, Philipp; Singer, Heinz; Sarrà, Montserrat; Hollender, Juliane; Vicent, Teresa; Rodríguez-Mozaz, Sara; Barceló, Damià

doi:10.1016/j.watres.2014.04.042

Cited by 103 publications

(65 citation statements)

References 43 publications

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“…Six transformation products (TPs) were detected under these experimental conditions, and their possible participation in the biotransformation pathway was explained according to identified structures as it is shown in Fig. 4 (Gros et al 2014). This TP 651 is reported to be produced from the loss of CHI which indicates the loss of one iodine atom and the N-demethylation in side chain A (Gros et al 2014).…”

Section: Biotransformation Pathway Of Iopromidementioning

confidence: 93%

Immobilization of biogenic Pd(0) in anaerobic granular sludge for the biotransformation of recalcitrant halogenated pollutants in UASB reactors

Pat-Espadas

Razo-Flores

Rangel-Mendez

et al. 2015

Appl Microbiol Biotechnol

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The capacity of anaerobic granular sludge to reduce Pd(II), using ethanol as electron donor, in an upflow anaerobic sludge blanket (UASB) reactor was demonstrated. Results confirmed complete reduction of Pd(II) and immobilization as Pd(0) in the granular sludge. The Pd-enriched sludge was further evaluated regarding biotransformation of two recalcitrant halogenated pollutants: 3-chloro-nitrobenzene (3-CNB) and iopromide (IOP) in batch and continuous operation in UASB reactors. The superior removal capacity of the Pd-enriched biomass when compared with the control (not exposed to Pd) was demonstrated in both cases. Results revealed 80 % of IOP removal efficiency after 100 h of incubation in batch experiments performed with Pd-enriched biomass whereas only 28 % of removal efficiency was achieved in incubations with biomass lacking Pd. The UASB reactor operated with the Pd-enriched biomass achieved 81 ± 9.5 % removal efficiency of IOP and only 61 ± 8.3 % occurred in the control reactor lacking Pd. Regarding 3-CNB, it was demonstrated that biogenic Pd(0) promoted both nitro-reduction and dehalogenation resulting in the complete conversion of 3-CNB to aniline while in the control experiment only nitro-reduction was documented. The complete biotransformation pathway of both contaminants was proposed by high-performance liquid chromatography-mass spectrometry (HPLC-MS) analysis evidencing a higher degree of nitro-reduction and dehalogenation of both contaminants in the experiments with Pd-enriched anaerobic sludge as compared with the control. A biotechnological process is proposed to recover Pd(II) from industrial streams and to immobilize it in anaerobic granular sludge. The Pd-enriched biomass is also proposed as a biocatalyst to achieve the biotransformation of recalcitrant compounds in UASB reactors.

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Section: Biotransformation Pathway Of Iopromidementioning

confidence: 93%

Immobilization of biogenic Pd(0) in anaerobic granular sludge for the biotransformation of recalcitrant halogenated pollutants in UASB reactors

Pat-Espadas

Razo-Flores

Rangel-Mendez

et al. 2015

Appl Microbiol Biotechnol

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“…Conversion of ofloxacin by a T. versicolor strain was reported by Gros et al (2014). No defluorinated intermediates were found; instead, transformation occurred by oxidation, hydroxylation, cleavage, and removal of the piperazine ring.…”

Section: Quinolonesmentioning

confidence: 86%

The biodegradation vs. biotransformation of fluorosubstituted aromatics

Kiel

Engesser

2015

Appl Microbiol Biotechnol

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Fluoroaromatics are widely and--in recent years--increasingly used as agrochemicals, starting materials for chemical syntheses and especially pharmaceuticals. This originates from the special properties the carbon-fluorine bond is imposing on organic molecules. Hence, fluoro-substituted compounds more and more are considered to be important potential environmental contaminants. On the other hand, the microbial potentials for their transformation and mineralization have received less attention in comparison to other haloaromatics. Due to the high electronegativity of the fluorine atom, its small size, and the extraordinary strength of the C-F bond, enzymes and mechanisms known to facilitate the degradation of chloro- or bromoarenes are not necessarily equally active with fluoroaromatics. Here, we review the literature on the microbial degradation of ring and side-chain fluorinated aromatic compounds under aerobic and anaerobic conditions, with particular emphasis being placed on the mechanisms of defluorination reactions.

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“…In these processes, microorganisms can produce Fe-or Mn-oxides, which are used to remove pharmaceuticals by chemical oxidation. In addition, bacteria can work in advanced oxidation together with Fe which is known as biologically catalyzed advanced oxidation (Marco-Urrea et al, 2009;Gros et al, 2014).…”

Section: Biological-related Removalmentioning

confidence: 99%

“…The biological Fenton-like reaction occurs in the presence of lignin-derived quinone (2,6,-dimethoxy-1,4-benzoquinone, DBQ) and Fe 3C (Fig. 3) (Marco-Urrea et al, 2009;Gros et al, 2014). In this process, DBQ is reduced to hydroquinone (DBQH 2 ) in the presence of an intracellular quinone reductase produced from the fungi, followed by the generation of semiquinone radicals (DBQ ¡ ) via subsequent oxidation of DBQH 2 by lignin-modifying enzymes (laccases and peroxidases) which are also from the white-rot fungi.…”

Section: Biological-related Removalmentioning

confidence: 99%

“…BioMnOx used for pharmaceutical removal can be produced by P. putida MnB6 (BCCM/ LMG 2322), which is grown in synthetic medium (Forrez et al, 2010;Forrez et al, 2011;Meerburg et al, 2012;Furgal et al, 2015). Similarly, the biological Fentonlike system with the white-rot fungi T. versicolor , 2013;Gros et al, 2014). Thus, specific cultivation equipment and sterile conditions are needed, and this might limit further application of these technologies in pharmaceutical removal technologies.…”

Section: Treatment Conditionsmentioning

confidence: 99%

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Pharmaceutical removal from water with iron- or manganese-based technologies: A review

Liu

Sutton

Rijnaarts

et al. 2016

Critical Reviews in Environmental Science and Technology

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Pharmaceuticals are detected at trace levels in waters. Their adverse effects on aquatic ecosystems and human health demand novel pharmaceutical removal technologies for treating wastewater effluents. Iron (Fe) or manganese (Mn) may play important roles in these new technologies since these metals are abundantly available at low costs and are known to contribute to organic conversions via physico-chemical, chemical, and biologically related processes. Few reviews describe and discuss Fe-or Mn-based technologies for the purpose to remove pharmaceuticals from water. Therefore, we review the current literature sorted into the three removal mechanisms, that is., through physico-chemical, chemical, and biological processes. The principals, performance, and influential parameters of these three types of technologies are described. Current and potential applications of these technologies are critically evaluated in order to identify advantages and challenges. In addition, the Fe-or Mn-based technologies which are currently not used but promising to further develop to remove pharmaceuticals cost efficiently are proposed.

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Biodegradation of the X-ray contrast agent iopromide and the fluoroquinolone antibiotic ofloxacin by the white rot fungus Trametes versicolor in hospital wastewaters and identification of degradation products

Cited by 103 publications

References 43 publications

Immobilization of biogenic Pd(0) in anaerobic granular sludge for the biotransformation of recalcitrant halogenated pollutants in UASB reactors

Immobilization of biogenic Pd(0) in anaerobic granular sludge for the biotransformation of recalcitrant halogenated pollutants in UASB reactors

The biodegradation vs. biotransformation of fluorosubstituted aromatics

Pharmaceutical removal from water with iron- or manganese-based technologies: A review

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