Biodegradation of oxidized regenerated cellulose

Dimitrijevich, Slobodan D.; Tatarko, Marek; Gracy, Robert W.; Linsky, C. B.; Olsen, Carl Erik

doi:10.1016/0008-6215(90)84169-u

Cited by 70 publications

(56 citation statements)

References 17 publications

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“…Rayon/viscose used for manufacturing of oxidized cellulose is an "artificial" material-it is known also as an "artificial silk"-originating from wood pulp of very different cellulose sources and converted into rayon/viscose [13]. Oxidized cellulose such as used in this study originates from natural plant based cotton is being purely natural cotton material [14]. The structure of natural cotton is thus basically different from rayon and viscose fibers.…”

Section: Discussionmentioning

confidence: 99%

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New Hemostatic Powder (GelitaCel Ca Powder<sup>TM</sup>) and Its Application in Cranial Neurosurgery

Menovsky¹,

Kamerling²,

Sener³

et al. 2014

OJMN

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Background: Intraoperative hemostasis during intracranial surgery is one of the most important aspects of the surgical procedure. One of the most widely practiced methods to prevent postoperative hemorrhage is to cover the cerebral wound bed with cellulose. Objective: We report on the use of a new powder form of regenerated oxidized cellulose enriched with calcium (GelitaCel Ca Powder™, Gelita Medical, Eberbach, Germany) for hemostasis purposes in intracranial surgery. Methods: In 107 patients operated for intracranial mass lesions, the resection cavity was covered with a small layer of cellulose powder for hemostatic purposes. All patients had a postoperative CT or MRI scanning within 24 hours after surgery to detect any surgical complications and to detect the presence of blood within the surgical cavity. Results: Of the 107 operated patients, 96 (90%) had no or minimal blood in the intracranial resection field on postoperative imaging with CT or MRI. Of those 96, 69 patients had no blood at all and 27 patients had a small trace. In the remaining 11 patients, 8 patients (7.5%) had blood filling the resection cavity. In three patients (2.8%), the blood accumulation resulted in mass effect. All these three patients were re-operated due to neurological deterioration. Conclusion: We suggest that cellulose powder is an easy and safe product for hemostasis and prevention of postoperative hemorrhage in intracranial surgery. The main advantage of the powder form over regular oxidized cellulose is the no-touch technique of application and leaves no excess hemostatic material behind which could possibly cause compression.

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Section: Discussionmentioning

confidence: 99%

“…The structure of natural cotton is thus basically different from rayon and viscose fibers. For hemostatic purposes, the natural cotton has an increased surface due to the irregular natural structure of the cotton fibers in comparison with rayon/viscose [14].…”

Section: Discussionmentioning

confidence: 99%

New Hemostatic Powder (GelitaCel Ca Powder<sup>TM</sup>) and Its Application in Cranial Neurosurgery

Menovsky¹,

Kamerling²,

Sener³

et al. 2014

OJMN

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“…adsorbable (28,29,32), will presumably be well tolerated in the airways and lungs. Although it is assumed that OC particles that reach the deeper regions of the lungs will dissolve, degrade, and undergo macrophagial clearance (33), we propose use of 5-15 mM OC particles to allow for their deposition in the extrathoracic and upper bronchial regions, to further decrease risk of toxicity and enhance airway clearance (34).…”

Section: Discussionmentioning

confidence: 99%

Oxidized Cellulose Binding to Allergens with a Carbohydrate-Binding Module Attenuates Allergic Reactions

Shani

Shani²,

Shoseyov

et al. 2011

The Journal of Immunology

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Grass and mite allergens are of the main causes of allergy and asthma. A carbohydrate-binding module (CBM) represents a common motif to groups I (β-expansin) and II/III (expansin-like) grass allergens and is suggested to mediate allergen-IgE binding. House dust mite group II allergen (Der p 2 and Der f 2) structures bear strong similarity to expansin's CBM, suggesting their ability to bind carbohydrates. Thus, this study proposes the design of a carbohydrate-based treatment in which allergen binding to carbohydrate particles will promote allergen airway clearance and prevent allergic reactions. The aim of the study was to identify a polysaccharide with high allergen-binding capacities and to explore its ability to prevent allergy. Oxidized cellulose (OC) demonstrated allergen-binding capacities toward grass and mite allergens that surpassed those of any other polysaccharide examined in this study. Furthermore, inhalant preparations of OC microparticles attenuated allergic lung inflammation in rye grass-sensitized Brown Norway rats and OVA-sensitized BALB/c mice. Fluorescently labeled OC efficiently cleared from the mouse airways and body organs. Moreover, long-term administration of OC inhalant to Wistar rats did not result in toxicity. In conclusion, many allergens, such as grass and dust mite, contain a common CBM motif. OC demonstrates a strong and relatively specific allergen-binding capacity to CBM-containing allergens. OC's ability to attenuate allergic inflammation, together with its documented safety record, forms a firm basis for its application as an alternative treatment for prevention and relief of allergy and asthma.

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“…Oxycellulose (OC) (Fig. 1a) is a semi-synthetic derivative of naturally occurring cellulose which undergoes chemical depolymerization and enzymatic hydrolysis under in vivo conditions (3,4). Being a non-toxic, biodegradable, biocompatible and bioresorbable polymer (5,6), OC is a well-established surgical material commercially available as a knitted fabric or staple fibre used in humans to stop bleeding and prevent the undesirable tissue adhesion occurring during post-operative healing processes (7,8).…”

Section: Introductionmentioning

confidence: 99%

Oxycellulose Beads with Drug Exhibiting pH-Dependent Solubility

Bajerová

Krejčová²,

Rabišková

et al. 2011

AAPS PharmSciTech

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Abstract. The aim of this study was to develop novel hydrogel-based beads and characterize their potential to deliver and release a drug exhibiting pH-dependent solubility into distal parts of gastrointestinal (GI) tract. Oxycellulose beads containing diclofenac sodium as a model drug were prepared by the ionotropic external gelation technique using calcium chloride solution as the crosslinking medium. Resulting beads were characterized in terms of particle shape and size, encapsulation efficacy, swelling ability and in vitro drug release. Also, potential drug-polymer interactions were evaluated using Fourier transform infrared spectroscopy. The particle size was found to be 0.92-0.96 mm for inactive (oxycellulose only) and 1.47-1.60 mm for active (oxycellulose-diclofenac sodium) beads, respectively. In all cases, the sphericity factor was between 0.70 and 0.81 with higher values observed for samples containing higher polymer and drug concentrations. The swelling of inactive beads was found to be strongly influenced by the pH and composition (i.e. Na + concentration) of the selected media (simulated gastric fluid vs. phosphate buffer pH 6.8). The encapsulation efficiency of the prepared particles ranged from 58% to 65%. Results of dissolution tests showed that the drug loading inside of the particles influenced the rate of its release. In general, prepared particles were able to release the drug within 12-16 h after a lag time of 4 h. Fickian diffusion was found as the predominant drug release mechanism. Thus, this novel particulate system showed a good potential to deliver drugs specifically to the distal parts of the human GI tract.

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Biodegradation of oxidized regenerated cellulose

Cited by 70 publications

References 17 publications

New Hemostatic Powder (GelitaCel Ca Powder<sup>TM</sup>) and Its Application in Cranial Neurosurgery

New Hemostatic Powder (GelitaCel Ca Powder<sup>TM</sup>) and Its Application in Cranial Neurosurgery

Oxidized Cellulose Binding to Allergens with a Carbohydrate-Binding Module Attenuates Allergic Reactions

Oxycellulose Beads with Drug Exhibiting pH-Dependent Solubility

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Biodegradation of oxidized regenerated cellulose

Cited by 70 publications

References 17 publications

New Hemostatic Powder (GelitaCel Ca Powder&lt;sup&gt;TM&lt;/sup&gt;) and Its Application in Cranial Neurosurgery

New Hemostatic Powder (GelitaCel Ca Powder&lt;sup&gt;TM&lt;/sup&gt;) and Its Application in Cranial Neurosurgery

Oxidized Cellulose Binding to Allergens with a Carbohydrate-Binding Module Attenuates Allergic Reactions

Oxycellulose Beads with Drug Exhibiting pH-Dependent Solubility

Contact Info

Product

Resources

About

New Hemostatic Powder (GelitaCel Ca Powder<sup>TM</sup>) and Its Application in Cranial Neurosurgery

New Hemostatic Powder (GelitaCel Ca Powder<sup>TM</sup>) and Its Application in Cranial Neurosurgery