Biodegradation of microplastic by probiotic bifidobacterium

Bozkurt, Hüseyin Sancar; Yörüklü, Hülya Civelek; Bozkurt, Kutsal; Denktaş, Cenk; Bozdoğan, Altan; Özdemi̇r, Orhan; Özkaya, Bestami

doi:10.1504/ijgw.2022.122435

Cited by 10 publications

(4 citation statements)

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“…Moreover, Bifidobacterium also has anti-IL-6, anti-inflammatory, as well as immune-enhancing effects ( 38 ). It can conduct biodegradation and destroy microplastics through its enzymatic hydrogen peroxide activation under semi-anaerobic conditions, thus predicting high exposure of microplastics in gastrointestinal systems with low Bifidobacterium levels ( 39 ). The abundance of Streptococcus and Sphingomonas is negatively correlated with the occurrence of colorectal cancer ( 40 , 41 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of microplastics on nasal and intestinal microbiota of the high-exposure population

Wang

Peng

Kang

et al. 2022

Front. Public Health

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BackgroundMicroplastic has become a growing environmental problem. A balanced microbial environment is an important factor in human health. This study is the first observational cross-sectional study focusing on the effects of microplastics on the nasal and gut microbiota in a highly exposed population.MethodsWe recruited 20 subjects from a Plastic Factory (microplastics high-exposure area) and the other 20 from Huanhuaxi Park (microplastics low-exposure area) in Chengdu, China. We performed the microplastic analysis of soil, air, and intestinal secretions by laser infrared imaging, and microbiological analysis of nasal and intestinal secretions by 16S rDNA sequencing.ResultsThe result shows that the detected points of microplastics in the environment of the high-exposure area were significantly more than in the low-exposure area. Polyurethane was the main microplastic component detected. The microplastic content of intestinal secretions in the high-exposure group was significantly higher than in the low-exposure group. Specifically, the contents of polyurethane, silicone resin, ethylene-vinyl acetate copolymer, and polyethylene in the high-exposure group were significantly higher than in the low-exposure group. Moreover, high exposure may increase the abundance of nasal microbiotas, which are positively associated with respiratory tract diseases, such as Klebsiella and Helicobacter, and reduce the abundance of those beneficial ones, such as Bacteroides. Simultaneously, it may increase the abundance of intestinal microbiotas, which are positively associated with digestive tract diseases, such as Bifidobacterium, Streptococcus, and Sphingomonas, and reduce the abundance of intestinal microbiotas, which are beneficial for health, such as Ruminococcus Torquesgroup, Dorea, Fusobacterium, and Coprococcus. A combined analysis revealed that high exposure to microplastics may not only lead to alterations in dominant intestinal and nasal microbiotas but also change the symbiotic relationship between intestinal and nasal microbiotas.ConclusionThe results innovatively revealed how microplastics can affect the intestinal and nasal microecosystems.Clinical trial registrationChiCTR2100049480 on August 2, 2021.

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Section: Discussionmentioning

confidence: 99%

Effect of microplastics on nasal and intestinal microbiota of the high-exposure population

Wang

Peng

Kang

et al. 2022

Front. Public Health

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“…Microplastics come from various aspects of human production and life, mainly including discharge of wastewater containing textile microfibers ( 44 ), fragmentation of agricultural plastic films ( 45 ), wear and tear of tires and road markings ( 46 ) and decomposition of plastic waste ( 47 ), which together result in the widespread presence of microplastics in global water environments. Although some scholars have reported that some functional microorganisms could degrade microplastics ( 48 , 49 ), this process is relatively slow, and microplastics are still easily ingested by aquatic organisms and spread through the food chain, which can affect the normal growth and development of organisms ( 8 , 50 ). This article described the types and quantities of microplastics found in the waters and sediments of 8 typical parks in Changsha.…”

Section: Discussionmentioning

confidence: 99%

Distribution patterns and environmental risk assessments of microplastics in the lake waters and sediments from eight typical wetland parks in Changsha city, China

Yao,

Li,

et al. 2024

Front. Public Health

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The quality of water in urban parks is closely related to people’s daily lives, but the pollution caused by microplastics in park water and sediments has not been comprehensively studied. Therefore, eight typical parks in the urban area of Changsha, China, were selected, and Raman spectroscopy was used to explore the spatial distributions and compositions of the microplastics in the water and sediments, analyze their influencing factors, and evaluate their environmental risks. The results showed that the abundances of surface water microplastics in all parks ranged from 150 to 525 n L−1, and the abundances of sediment microplastics ranged from 120 to 585 n kg−1. The microplastics in the surface water included polyethylene terephthalate (PET), chlorinated polyethylene (CPE), and fluororubber (FLU), while those in the sediments included polyvinyl chloride (PVC), wp-acrylate copolymer (ACR), and CPE. Regression analyses revealed significant positive correlations between human activities and the abundances of microplastics in the parks. Among them, the correlations of population, industrial discharge and domestic wastewater discharge with the abundance of microplastics in park water were the strongest. However, the correlations of car flow and tourists with the abundance of microplastics in park water were the weakest. Based on the potential ecological risk indices (PERI) classification assessment method, the levels of microplastics in the waters and sediments of the eight parks were all within the II-level risk zone (53–8,549), among which the risk indices for Meixi Lake and Yudai Lake were within the IV risk zone (1,365–8,549), which may have been caused by the high population density near the park. This study provides new insights into the characteristics of microplastics in urban park water and sediment.

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“…These changes can result in elevated expression of key biomarkers, including TLR4, AP-1, and IRF5, which are associated with pronounced inflammatory responses. These inflammatory cascades play a pivotal role in chronic carcinogenic processes and may ultimately lead to tumorigenesis [ 67 , 68 ]. Intratumoural microbiota can inhibit cytotoxic immune cell infiltration and achieve immune evasion by impairing anti-tumor immunity and blocking its ability to kill tumor cells [ 12 ], ultimately affecting tumorigenesis and progression [ 56 ].…”

Section: Intratumoural Microbiota and Cancermentioning

confidence: 99%

“…Bifidobacterium unique EP structure which has the electrogenic activity and hygrophilic properties for the carbon requirement required for energy provides adhesion on surfaces.It has been discovered that Bifidobacterium can attach to the surface of polypropylene (PP), forming a biofilm that controls the growth of pathogenic bacteria. Additionally, the biofilm reduces the growth of Escherichia coli O157:H7 , Listeria monocytogenes , Staphylococcus aureus , and Salmonella enterica on the surface of PP [ 68 , 91 ]. Additionally, the research indicates that IL-6 is a pro-inflammatory cytokine, and elevated levels of IL-6 are associated with the occurrence and progression of various cancers, including breast cancer, colorectal cancer, gastric cancer, ovarian cancer, and others.…”

Section: Intratumoural Microbiota and Cancermentioning

confidence: 99%

Intratumoural microbiota: from theory to clinical application

Jiang

Chen

et al. 2023

Cell Commun Signal

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Cancer is a major cause of high morbidity and mortality worldwide. Several environmental, genetic and lifestyle factors are associated with the development of cancer in humans and result in suboptimal treatment. The human microbiota has been implicated in the pathophysiological process of cancer and has been used as a diagnostic, prognostic and risk assessment tool in cancer management. Notably, both extratumoural and intratumoural microbiota are important components of the tumor microenvironment, subtly influencing tumorigenesis, progression, treatment and prognosis. The potential oncogenic mechanisms of action of the intratumoural microbiota include induction of DNA damage, influence on cell signaling pathways and impairment of immune responses. Some naturally occurring or genetically engineered microorganisms can specifically accumulate and replicate in tumors and then initiate various anti-tumor programs, ultimately promoting the therapeutic effect of tumor microbiota and reducing the toxic and side effects of conventional tumor treatments, which may be conducive to the pursuit of accurate cancer treatment. In this review, we summarise evidence revealing the impact of the intratumoural microbiota on cancer occurrence and progress and potential therapeutic and diagnostic applications, which may be a promising novel strategy to inhibit tumor development and enhance therapeutic efficacy.

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Biodegradation of microplastic by probiotic bifidobacterium

Cited by 10 publications

References 0 publications

Effect of microplastics on nasal and intestinal microbiota of the high-exposure population

Effect of microplastics on nasal and intestinal microbiota of the high-exposure population

Distribution patterns and environmental risk assessments of microplastics in the lake waters and sediments from eight typical wetland parks in Changsha city, China

Intratumoural microbiota: from theory to clinical application

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