Biodegradation of Hyaluronan

New amphiphilic hyaluronan derivatives based on modification with alkenyl and aryl succinic anhydrides

“…A human adult contain approximately 15 g hyaluronic acid. Hyaluronic acid occurs in the eyes, skin (in both epidermis and dermis) and synovial fluid (Lepperdinger, Fehrer, & Reitinger, 2004). Further, hyaluronic acid makes up the backbone of the proteoglycan aggregates being a main component of sinew and cartilage (Heinegård, Björnsson, Mörgelin, & Sommarin, 1998).…”

“…The polysaccharide has a high turnover in the body, 7 g/day, i.e. half of all HA in the body is exchanged every day (Lepperdinger et al, 2004). The molecular weight strongly depends on the biological origin (Lapcik, Lapcik, De Smedt, & Demeester, 1998).…”

A bridge to silencing: Co-assembling anionic nanoparticles of siRNA and hyaluronan sulfate via calcium ion bridges

“…The semi-synthetic glycosaminoglycan, hyaluronan-sulfate (HAS) [15] was selected as it is less susceptible to enzymatic degradation compared to non-modified HA [16], thus potentially leading to stable carriers in vivo, and since it has multiple functional groups available for targeting ligand attachment [17].…”

Effect of Bucillamine on Free-Radical-Mediated Degradation of High-Molar-Mass Hyaluronan Induced in vitro by Ascorbic Acid and Cu(II) Ions

“…A 70-kg human body contains approximately 15 g of HA [10]. Every day about one third of this amount is turned over.…”