Biodegradation of four calcium phosphate ceramics;in vivo rates and tissue interactions

Ramselaar, M. M. A.; Driessens, F. C. M.; Kalk, W.; Wijn, J.R. de; Mullem, P.J. van

doi:10.1007/bf00703460

Cited by 55 publications

(27 citation statements)

References 15 publications

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“…models, including rabbit (Patel et al , 2002;Tamai et al , 2002), pig (Chu et al , 2002;Ramselaar et al , 1991) and dog (Kikuchi et al , 2001). In human patients, the use of hydroxyapatite-coated pins for external fi xation of unstable wrist fractures indicated potentially superior clinical performance; however, the difference in healing outcomes in this study was not statistically signifi cant (Pieske et al , 2010).…”

Section: Hydroxyapatitementioning

confidence: 64%

Advanced bioactive and biodegradable ceramic biomaterials

Ivanova¹,

Bazaka²,

Crawford³

2014

New Functional Biomaterials for Medicine and Healthcare

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Section: Hydroxyapatitementioning

confidence: 64%

Advanced bioactive and biodegradable ceramic biomaterials

Ivanova¹,

Bazaka²,

Crawford³

2014

New Functional Biomaterials for Medicine and Healthcare

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“…This reaction is supported by work by Ramselaar et al 15,16 These authors mixed particles of rhenanite and hydroxylapatite with gelatin and introduced the material into tooth sockets of beagles for periods of 3 and 6 months. Rhenanite transformed into apatite.…”

Section: Corrosionmentioning

confidence: 75%

Porous bioactive glass and glass-ceramics made by reaction sintering under pressure

Gong

Abdelouas

Lutze

2000

J. Biomed. Mater. Res.

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A glass and a rhenanite-wollastonite glass-ceramic were synthesized with the qualitative composition Na2O-CaO-SiO2-P2O5. Both materials were prepared by reaction sintering under isostatic pressure (RSIP) using powder mixtures. Solid state reactions were complete within a few hours at 950 degrees C under modest pressure. Formation of the glass and crystalline phases was driven by an intermediate, reactive, low viscosity Na2O-SiO2 phase. A reaction mechanism is suggested. Porous materials were obtained with two ranges of pore sizes: 100-200 microm and < or =5 microm in diameter. The glass and the glass-ceramic were corroded in simulated body fluid at 37 degrees C. The evolution of surface features was studied. Gel layers formed on both materials. Corrosion was fastest inside the pores. Microcrystals of apatite were identified by crystal structure analysis and by chemical analysis. During corrosion of the glass-ceramic, rhenanite most likely was converted into apatite. Comparison of these results with published information suggests that the glass and glass-ceramic are bioactive. We suggest that RSIP can be used (a) to control the surface porosity and pore size of bioactive implants, thereby increasing the stability of tissue/implant interfaces; (b) to make glasses and glass-ceramics with new properties; and (c) to make near net-shape materials.

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“…Little is known about bioresorption of whitlockite. A previous study has concluded that, in vivo, whitlockite was biodegraded at a faster rate than HA - because of differences in density and pore diameter - but at a slower rate than β-TCP, due probably to the presence of metal oxides that may make the material less resorbable [42]. Magnesium incorporation was also shown to stimulate human osteoblast proliferation [43] making whitlockite less quickly resorbable than β-TCP but more osteoinductive, thus with an interesting range of application in bone engineering.…”

Section: Resultsmentioning

confidence: 97%

The Role of Carboxydothermus hydrogenoformans in the Conversion of Calcium Phosphate from Amorphous to Crystalline State

et al. 2014

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Two previously unknown modes of biomineralization observed in the presence of Carboxydothermus hydrogenoformans are presented. Following the addition of NaHCO3 and the formation of an amorphous calcium phosphate precipitate in a DSMZ medium inoculated with C. hydrogenoformans, two distinct crystalline solids were recovered after 15 and 30 days of incubation. The first of these solids occurred as micrometric clusters of blocky, angular crystals, which were associated with bacterial biofilm. The second solid occurred as 30–50 nm nanorods that were found scattered among the organic products of bacterial lysis. The biphasic mixture of solids was clearly dominated by the first phase. The X-ray diffractometry (XRD) peaks and Fourier transform infrared spectroscopy (FTIR) spectrum of this biphasic material consistently showed features characteristic of Mg-whitlockite. No organic content or protein could be identified by dissolving the solids. In both cases, the mode of biomineralization appears to be biologically induced rather than biologically controlled. Since Mg is known to be a strong inhibitor of the nucleation and growth of CaP, C. hydrogenoformans may act by providing sites that chelate Mg or form complexes with it, thus decreasing its activity as nucleation and crystal growth inhibitor. The synthesis of whitlockite and nano-HAP-like material by C. hydrogenoformans demonstrates the versatility of this organism also known for its ability to perform the water-gas shift reaction, and may have applications in bacterially mediated synthesis of CaP materials, as an environmentally friendly alternative process.

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Biodegradation of four calcium phosphate ceramics;in vivo rates and tissue interactions

Cited by 55 publications

References 15 publications

Advanced bioactive and biodegradable ceramic biomaterials

Advanced bioactive and biodegradable ceramic biomaterials

Porous bioactive glass and glass-ceramics made by reaction sintering under pressure

The Role of Carboxydothermus hydrogenoformans in the Conversion of Calcium Phosphate from Amorphous to Crystalline State

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