Biodegradation of environmental pollutant through pathways engineering and genetically modified organisms approaches

Kumar, Ravi Shankar; Singh, Deeksha; Bose, S. K.; Trivedi, Prabodh Kumar

doi:10.1016/b978-0-12-819001-2.00007-3

Cited by 9 publications

(2 citation statements)

References 102 publications

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“…Although genomics, metabolomics, and proteomics in bioremediation aid in the exploration of possible solutions to specific pollutants, identifying and comparing gene and protein sequences that are effective at removing contaminants is the next step in bioremediation research. GMOs can clean up a wide range of waste effluents and polluted land [183]. When used in conjunction with other physical and chemical methods, bioremediation can provide a comprehensive approach toward removing pollution from the environment.…”

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

Recent Strategies for Bioremediation of Emerging Pollutants: A Review for a Green and Sustainable Environment

Bala

Garg

Thirumalesh

et al. 2022

Toxics

232

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Environmental pollution brought on by xenobiotics and other related recalcitrant compounds have recently been identified as a major risk to both human health and the natural environment. Due to their toxicity and non-biodegradability, a wide range of pollutants, such as heavy metals, polychlorinated biphenyls, plastics, and various agrochemicals are present in the environment. Bioremediation is an effective cleaning technique for removing toxic waste from polluted environments that is gaining popularity. Various microorganisms, including aerobes and anaerobes, are used in bioremediation to treat contaminated sites. Microorganisms play a major role in bioremediation, given that it is a process in which hazardous wastes and pollutants are eliminated, degraded, detoxified, and immobilized. Pollutants are degraded and converted to less toxic forms, which is a primary goal of bioremediation. Ex situ or in situ bioremediation can be used, depending on a variety of factors, such as cost, pollutant types, and concentration. As a result, a suitable bioremediation method has been chosen. This review focuses on the most recent developments in bioremediation techniques, how microorganisms break down different pollutants, and what the future holds for bioremediation in order to reduce the amount of pollution in the world.

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Section: Future Perspectives and Conclusionmentioning

confidence: 99%

Recent Strategies for Bioremediation of Emerging Pollutants: A Review for a Green and Sustainable Environment

Bala

Garg

Thirumalesh

et al. 2022

Toxics

232

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“…[15] In industries, it works as a catalyst, corrosion inhibitor, separating agent, optical brighteners, wax emulsifier, and surface-active agents. [16] Besides this, it has wide agricultural applications, i. e., fenpropimorphan which is extensively used in cereals as a fungicides. [17] Tyrosinase encompassing Cu (EC 1.14.18.1) biosynthesizes melanin pigment significantly.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Computational Exploration of Morpholine Bearing Halogenated Sulfonamides as Potential Tyrosinase Inhibitors

Abbasi

Raza

Siddiqui

et al. 2023

Chemistry & Biodiversity

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In the presented work, a novel series of three different 4‐((3,5‐dichloro‐2‐[(2/4‐halobenzyl)oxy]phenyl)sulfonyl)morpholines was synthesized and the structure of these compounds were corroborated by 1H‐NMR & 13C‐NMR studies. The in vitro results established all the three compounds as potent tyrosinase inhibitors relative to the standard. The Kinetics mechanism plots established that compound 8 inhibited the enzyme non‐competitively. The inhibition constants Ki calculated from Dixon plots for this compound was 0.0025µM. Additionally, computational techniques were used to explore electronic structures of synthesized compounds. Fully optimized geometries were further docked with tyrosinase enzyme for inhibition studies. Reasonably good binding/interaction energies and intermolecular interactions were obtained. Finally, drug likeness was also predicted using the rule of five (RO5) and Chemical absorption, distribution, metabolism, excretion, and toxicity (ADMET) characteristics. It is anticipated that current experimental and computational investigations will evoke the scientific interest of the research community for the above‐entitled compounds.

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Fundamentals of Biodegradation Process

Doukani

Boukirat

Boumezrag

et al. 2022

Handbook of Biodegradable Materials

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Biodegradation of environmental pollutant through pathways engineering and genetically modified organisms approaches

Cited by 9 publications

References 102 publications

Recent Strategies for Bioremediation of Emerging Pollutants: A Review for a Green and Sustainable Environment

Recent Strategies for Bioremediation of Emerging Pollutants: A Review for a Green and Sustainable Environment

Synthesis and Computational Exploration of Morpholine Bearing Halogenated Sulfonamides as Potential Tyrosinase Inhibitors

Fundamentals of Biodegradation Process

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