Abstract:From rat liver cytosol, an enzyme was isolated which catalyzes the dechlorination of alpha-, gamma-, and delta-HCH. The enzyme also catalyzes the conjugation of GSH with 1,2-dichloro-4-nitrobenzene, and with 1 -chloro-2,4-dinitrobenzene. The enzyme has a molecular weight of about 46000 and its molecule is composed of two subunits of similar size. The optimum for the dechlorination of alpha-HCH lies at pH 8.0. The Michaelis constant is 0.12 mM for alpha-HCH (with 1 mM GSH as constant substrate), and maximal vel… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.