Biodegradation and reversible inhibitory impact of sulfamethoxazole on the utilization of volatile fatty acids during anaerobic treatment of pharmaceutical industry wastewater

Cetecioglu, Zeynep; İnce, Bahar; Gros, Meritxell; Rodríguez-Mozaz, Sara; Barceló, Damià; İnce, Orhan; Orhon, Derin

doi:10.1016/j.scitotenv.2015.07.139

Cited by 83 publications

(36 citation statements)

References 36 publications

(44 reference statements)

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“…3). This finding is consistent with other studies that suggest the stepwise processes, such as nitrification and anaerobic digestion, are largely determined by the composition of functional microbial groups more than resistance genes363738. Some key functional gene hosts identified in this study, such as Hypomicrobium, Caldilinea and Thauera , were also reportedly reducing NO and N 2 O under antibiotics or toxicants stressed habitats3940, where higher abundances of Hypomicrobium carrying norB and nosZ were reckoned to process a more complete denitrification41, probably because these two genes, compared to nir, nap and nar gene clusters, have comparatively low functional redundancy42 and therefore are likely to be the ceiling factors of the denitrifying process, especially under extreme conditions.…”

Section: Discussionsupporting

confidence: 93%

Change in microbial community in landfill refuse contaminated with antibiotics facilitates denitrification more than the increase in ARG over long-term

Chen

Zhang

et al. 2017

Sci Rep

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In this study, the addition of sulfamethazine (SMT) to landfill refuse decreased nitrogen intermediates (e.g. N2O and NO) and dinitrogen (N2) gas fluxes to <0.5 μg-N/kg-refuse·h−1, while the N2O and N2 flux were at ~1.5 and 5.0 μg-N/kg-refuse·h−1 respectively in samples to which oxytetracycline (OTC) had been added. The ARG (antibiotic resistance gene) levels in the refuse increased tenfold after long-term exposure to antibiotics, followed by a fourfold increase in the N2 flux, but SMT-amended samples with the largest resistome facilitated the denitrification (the nitrogen accumulated as NO gas at ~6 μg-N/kg-refuse·h−1) to a lesser extent than OTC-amended samples. Further, deep sequencing results show that long-term OTC exposure partially substituted Hyphomicrobium, Fulvivirga, and Caldilinea (>5%) for the dominant bacterial hosts (Rhodothermus, ~20%) harboring nosZ and norB genes that significantly correlated with nitrogen emission pattern, while sulfamethazine amendment completely reduced the relative abundance of the “original inhabitants” functioning to produce NOx gas reduction. The main ARG carriers (Pseudomonas) that were substantially enriched in the SMT group had lower levels of denitrifying functional genes, which could imply that denitrification is influenced more by bacterial dynamics than by abundance of ARGs under antibiotic pressures.

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Section: Discussionsupporting

confidence: 93%

Change in microbial community in landfill refuse contaminated with antibiotics facilitates denitrification more than the increase in ARG over long-term

Chen

Zhang

et al. 2017

Sci Rep

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“…Aydin et al (2015) observed that addition of sulfamethoxazole, erythromycin, and tetracycline at 15–20, 1.5, and 1.5 mg/L concentrations, respectively, could produce 400 to 600 mg/L of volatile fatty acids (VFA). Similarly, Cetecioglu et al (2015a) noted that increasing the concentrations of sulfamethoxazole to 45 mg/L could cause VFA to accumulate to a range of 35 to 438 mg/L in an anaerobic sequencing batch reactor (AnSBR).…”

Section: Introductionmentioning

confidence: 99%

“…Given the vital role microbes play in anaerobic digestion, studies characterizing the anaerobic microbial communities in the presence of antibiotics are essential to determining the potential impacts on methane and volatile fatty acids (VFA) production. Various studies have reported a general reduction in biogas volumes, primarily that of methane, when anaerobic reactors were exposed to antibiotics (Álvarez et al 2010; Bauer et al 2014; Cetecioglu et al 2015a; Cetecioglu et al 2013). When volatile fatty acids (VFAs) were further added as substrates, utilization rates were reduced and an accumulation of propionate was observed (Cetecioglu et al 2015a; Cetecioglu et al 2013; Cetecioglu et al 2015b).…”

Section: Introductionmentioning

confidence: 99%

“…Various studies have reported a general reduction in biogas volumes, primarily that of methane, when anaerobic reactors were exposed to antibiotics (Álvarez et al 2010; Bauer et al 2014; Cetecioglu et al 2015a; Cetecioglu et al 2013). When volatile fatty acids (VFAs) were further added as substrates, utilization rates were reduced and an accumulation of propionate was observed (Cetecioglu et al 2015a; Cetecioglu et al 2013; Cetecioglu et al 2015b). Lower abundance of functional genes related to acetogenesis and methanogenesis were quantified by qPCR (Cetecioglu et al 2015a), suggesting perturbations in the anaerobic microbial communities when reactors were subjected to high concentrations of antibiotics.…”

Section: Introductionmentioning

confidence: 99%

“…When volatile fatty acids (VFAs) were further added as substrates, utilization rates were reduced and an accumulation of propionate was observed (Cetecioglu et al 2015a; Cetecioglu et al 2013; Cetecioglu et al 2015b). Lower abundance of functional genes related to acetogenesis and methanogenesis were quantified by qPCR (Cetecioglu et al 2015a), suggesting perturbations in the anaerobic microbial communities when reactors were subjected to high concentrations of antibiotics.…”

Section: Introductionmentioning

confidence: 99%

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Performance and microbial community variations of anaerobic digesters under increasing tetracycline concentrations

Xiong

Harb

Hong

2017

Appl Microbiol Biotechnol

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The impact of different concentrations of tetracycline on the performance of anaerobic treatment was evaluated. Results revealed that for all of the tested tetracycline concentrations, no major sustained impact on methane production was observed. Instead, a significant increase in propionic acid was observed in the reactor subjected to the highest concentration of tetracycline (20 mg/L). Microbial community analyses suggest that an alternative methanogenic pathway, specifically that of methanol-utilizing methanogens, may be important for ensuring the stability of methane production in the presence of high tetracycline concentrations. In addition, the accumulation of propionate was due to an increase in volatile fatty acids (VFA)-producing bacteria coupled with a reduction in propionate utilizers. An increase in the abundance of tetracycline resistance genes associated with ribosomal protection proteins was observed after 30 days of exposure to high concentrations of tetracycline, while other targeted resistance genes showed no significant changes. These findings suggest that anaerobic treatment processes can robustly treat wastewater with varying concentrations of antibiotics while also deriving value-added products and minimizing the dissemination of associated antibiotic resistance genes.Electronic supplementary materialThe online version of this article (doi:10.1007/s00253-017-8253-1) contains supplementary material, which is available to authorized users.

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Detection and Treatment of Persistent Pollutants in Water: General Review of Pharmaceutical Products

2022

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Environmental problems of great complexity arise from the enormous number of toxic substances that are generated by anthropogenic activities. Seemingly, society encounters new issues every day thus these problems seem to be endless. Now in the face of the COVID‐19 pandemic and the SARS‐CoV‐2 crisis, a large number of emerging treatment compounds generated by pharmaceutical companies worldwide makes future issues even more treacherous. For this reason, there is an increasing need to detect and treat emerging compounds to prevent them from becoming persistent pollutants. This review describes the advances in the use of electrochemical sensors with modified carbon‐based electrodes among other issues, to determine antibiotics, anti‐inflammatories and antidepressants levels in the environment. It further explores technologies suggested for cleaning wastewater polluted by pharmaceutical products using biological or advanced oxidation processes including photolysis, photocatalysis, microwave heating, ultrasound, Fenton, electro‐Fenton, photoelectro‐Fenton and various combined treatments.

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Biodegradation and reversible inhibitory impact of sulfamethoxazole on the utilization of volatile fatty acids during anaerobic treatment of pharmaceutical industry wastewater

Cited by 83 publications

References 36 publications

Change in microbial community in landfill refuse contaminated with antibiotics facilitates denitrification more than the increase in ARG over long-term

Change in microbial community in landfill refuse contaminated with antibiotics facilitates denitrification more than the increase in ARG over long-term

Performance and microbial community variations of anaerobic digesters under increasing tetracycline concentrations

Detection and Treatment of Persistent Pollutants in Water: General Review of Pharmaceutical Products

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