Biodegradable Viral Nanoparticle/Polymer Implants Prepared <i>via</i> Melt-Processing

Lee, Parker W.; Shukla, Sourabh; Wallat, Jaqueline D.; Danda, Chaitanya; Steinmetz, Nicole F.; Maia, João M.; Pokorski, Jonathan K.

doi:10.1021/acsnano.7b02786

Cited by 50 publications

(54 citation statements)

References 61 publications

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“…Such modern vaccine delivery devices can be made by solution methods or fabricated via traditional polymer melt-processing (for example, injection moulding). The advantage of melt-processed devices lies in their potential for rapid manufacturing at large scale and their long-term stability independent of the cold chain [95][96][97][98] . The potential to break the cold chain and ease the burden on the medical system by offering a safe and effective self-administered prophylactic vaccine has been capitalized on by a number of companies such as Veleritas Inc., Zosano, Corium International and Debiotech, and has led to the filing of over 10,000 patents worldwide 99 .…”

Section: Focus |mentioning

confidence: 99%

COVID-19 vaccine development and a potential nanomaterial path forward

et al. 2020

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, a novel coronavirus (nCoV or SARS-CoV-2) belonging to the betacoronavirus family emerged 1,2. All human betacoronaviruses are unique from one another, however, they do share a certain degree of genetic and structural homology. SARS-CoV-2 genome sequence homology with SARS-CoV and MERS-CoV is 77% and 50%, respectively 3. In contrast to the relatively smaller outbreaks of SARS-CoV in 2002 and MERS-CoV in 2012, SARS-CoV-2 is exhibiting an unprecedented scale of infection, resulting in a global pandemic declaration of Coronavirus Infectious Disease (COVID-19) on 11 March 2020 by the World Health Organization (WHO). On 1 June 2020, the World Health Organization reported >6 million confirmed cases and 371 thousand deaths globally. Of note, during the 1918 influenza pandemic, more death was observed in the second phase of outbreak 4. Similar to influenza, COVID-19 harbours the potential to become a seasonal disease 5. The high infection rate, long incubation period, along with mild-to-moderate symptoms experienced by many, make COVID-19 a troubling disease. A vaccine is crucial, in particular because data indicate asymptomatic transmission of COVID-19 6-8. More than 10 years ago, scientists predicted the pandemic potential of the coronaviruses 9. And for the past 30 years, a once-per-decade novel coronavirus has pushed our public health system to the limit, with SARS-CoV-2 being the most severe. Despite the repeated warnings and discussion, the world was not prepared for this pandemic. The rapid development, distribution and administration of a vaccine to the global population is the most effective approach to quell this pandemic and the only one that will lead to a complete lifting of restrictions. Challenges include the vaccine design itself, but also its manufacture and global distribution; cold chain requirements present logistical and fiscal barriers to the availability of important, life-saving vaccines in resource-poor areas of the world. Innovating vaccine delivery platforms and devices to break cold chain limitations are therefore an efficient solution to safeguard potent vaccination for both wealthy and lower-income countries.

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Section: Focus |mentioning

confidence: 99%

COVID-19 vaccine development and a potential nanomaterial path forward

et al. 2020

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“…This homogenous dispersed composite materials for prolonged VP release are created by heating up PLGA and VP. 217 Another example of polyesters is polycaprolactone (PCL) which is widely used as long-term implants in biomedical applications due to their good mechanical properties, slow degradability and biocompatibility. 218 In recent years, electrospinning techniques emerged as a promising process to create PCL fibrous structures for sustained and localized gene delivery.…”

Section: Biomaterials Science Reviewmentioning

confidence: 99%

Materials promoting viral gene delivery

Kaygisiz

Synatschke

2020

Biomater. Sci.

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“…Viral nanoparticles (VNPs) are virus‐based nanoparticles that have been extensively studied as novel nanomaterials for various biomedical applications . VNPs derived from plant viruses are promising as vaccine adjuvants and for cancer immunotherapy due to their intrinsic immunostimulatory properties combined with the inability to cause infection in humans .…”

Section: Introductionmentioning

confidence: 99%

Cowpea Mosaic Virus Promotes Anti‐Tumor Activity and Immune Memory in a Mouse Ovarian Tumor Model

Wang

Fiering

Steinmetz

2019

Advanced Therapeutics

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Cowpea mosaic virus (CPMV) is a promising platform nanotechnology with applications as a cancer therapeutic. To understand the therapeutic potential of CPMV in more detail, its antitumor mechanisms are investigated using a syngeneic immunocompetent murine orthotopic ovarian cancer model (ID8-Defb29/Vegf-A). CPMV treatment in situ promotes tumor regression and prevents tumor recurrence. Although CPMV does not kill tumor cells directly, it promotes an intra-tumoral cytokine response which induces pre-existing myeloid cells to break immunotolerance and initiate antitumor responses. The upregulation of interleukin-6 and interferon-γ as well as the downregulation of IL-10 and transforming growth factor β are observed, associated with activation and repolarization of tumor-associated macrophages and neutrophils to an anti-tumor phenotype. Furthermore, the in situ administration of CPMV recruits dendritic cells and natural killer cells to the tumor site, and induces the expression of costimulatory molecules on CD11bmyeloid cells. By converting immunosuppressive myeloid cells into potent antigen-presenting cells, in situ CPMV treatment significantly improves effector and memory CD4 + and CD8 + T cell responses and promoted systemic tumor-specific cytotoxic CD8 + T cell activity. CPMV in situ immunotherapy induces significant tumor control in an aggressive ovarian tumor model by coordinating innate and adaptive immune responses involving neutrophils, macrophages, and T cells.

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Biodegradable Viral Nanoparticle/Polymer Implants Prepared via Melt-Processing

Cited by 50 publications

References 61 publications

COVID-19 vaccine development and a potential nanomaterial path forward

COVID-19 vaccine development and a potential nanomaterial path forward

Materials promoting viral gene delivery

Cowpea Mosaic Virus Promotes Anti‐Tumor Activity and Immune Memory in a Mouse Ovarian Tumor Model

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