Biodegradable ternary Zn–3Ge–0.5X (X=Cu, Mg, and Fe) alloys for orthopedic applications

Lin, Jixing; Tong, Xian; Sun, Quanxiang; Luan, Yanan; Zhang, Dechuang; Shi, Zhanbiao; Wang, Kun; Li, Yuncang; Dargusch, Matthew S.; Wen, Cuie

doi:10.1016/j.actbio.2020.08.033

Cited by 50 publications

(39 citation statements)

References 64 publications

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“…On the other hand, it is known that Zn has a hexagonal close-packed structure, and thus, the main plastic deformation strategy is the base sliding. 38 In the present study, the texture strength of Zn-CNTs (19.74) is decreased to 5.15 for Zn-CNTs@Ag, which is in favor of induction twin crystals and activates the base slip. 46 Additionally, Zn-CNTs@ Ag have more fine-grain boundaries (Figure 5b), which provides enough space for substrate slip, thereby improving the ductility.…”

Section: Resultsmentioning

confidence: 43%

“…The fraction of LAGBs determines the ductility of metals, as dislocations are easier to move through adjacent grains with slightly dislocated lattices. , As shown in Figure a, the fraction of LAGBs of Zn-CNTs (36.6%) increases to 41.1% in Zn-CNTs@Ag, which contributes to improving the ductility. On the other hand, it is known that Zn has a hexagonal close-packed structure, and thus, the main plastic deformation strategy is the base sliding . In the present study, the texture strength of Zn-CNTs (19.74) is decreased to 5.15 for Zn-CNTs@Ag, which is in favor of induction twin crystals and activates the base slip .…”

Section: Resultsmentioning

confidence: 51%

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Rivet-Inspired Modification of Carbon Nanotubes by In Situ-Reduced Ag Nanoparticles To Enhance the Strength and Ductility of Zn Implants

Shuai

Dong

Yang

et al. 2021

ACS Biomater. Sci. Eng.

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Zinc shows promise for bone repair applications, while its strength and ductility require to be improved. Carbon nanotubes (CNTs) are exceptional reinforcements due to their superior strength, ultrahigh Young’s modulus, and large aspect ratio. However, their strong agglomeration and weak interfacial bonding with the matrix are key bottleneck problems restricting the reinforcing effect. In this study, Ag nanoparticles were in situ reduced on CNTs and then the CNT@Ag powders were used to prepare Zn-CNT@Ag implants by laser powder bed fusion. Results showed that Ag reacted with Zn to form a “knot”-like AgZn3 phase. It had the same lattice structure (HCP) with Zn, which indicated a good lattice matching with the matrix, thus improving the dispersion of CNTs. More significantly, the knot played a “rivet” role and enhanced the load transfer capacity, which advantaged the CNT strengthening effects by assisting in transferring the load. Moreover, it enhanced the heterogeneous nucleation effects during solidification, which weakened the texture strength of the matrix and thus increased the ductility by improving the sliding capacity. The compressive yield strength, ultimate tensile strength, and elongation of the Zn-CNT@Ag implant were increased by 22, 26, and 17% in comparison to Zn-CNTs. Moreover, the Zn-CNT@Ag implant exhibited favorable antibacterial activity with a bacterial inhibition rate of 87.79%. Additionally, it also exhibited a suitable degradation rate and acceptable biocompatibility.

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Section: Resultsmentioning

confidence: 43%

Section: Resultsmentioning

confidence: 51%

Rivet-Inspired Modification of Carbon Nanotubes by In Situ-Reduced Ag Nanoparticles To Enhance the Strength and Ductility of Zn Implants

Shuai

Dong

Yang

et al. 2021

ACS Biomater. Sci. Eng.

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“…C, E, R, SPS and SLM refer to cast, extruded, rolled, spark plasma sintering and selective laser melting, respectively.) [ 107 , 109 , 132 , 135 , 137 , 138 , 141 , 142 , [144] , [145] , [146] , [147] , [148] , [149] , [150] , [151] , [152] , [153] , [154] , [155] ]. …”

Section: Current Research Status On Biomedical Zn-based Biodegradable Metalsmentioning

confidence: 99%

A review on current research status of the surface modification of Zn-based biodegradable metals

Yuan

Xia

et al. 2022

Bioactive Materials

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Recently, zinc and its alloys have been proposed as promising candidates for biodegradable metals (BMs), owning to their preferable corrosion behavior and acceptable biocompatibility in cardiovascular, bone and gastrointestinal environments, together with Mg-based and Fe-based BMs. However, there is the desire for surface treatment for Zn-based BMs to better control their biodegradation behavior. Firstly, the implantation of some Zn-based BMs in cardiovascular environment exhibited intimal activation with mild inflammation. Secondly, for orthopedic applications, the biodegradation rates of Zn-based BMs are relatively slow, resulting in a long-term retention after fulfilling their mission. Meanwhile, excessive Zn 2+ release during degradation will cause in vitro cytotoxicity and in vivo delayed osseointegration. In this review, we firstly summarized the current surface modification methods of Zn-based alloys for the industrial applications. Then we comprehensively summarized the recent progress of biomedical bulk Zn-based BMs as well as the corresponding surface modification strategies. Last but not least, the future perspectives towards the design of surface bio-functionalized coatings on Zn-based BMs for orthopedic and cardiovascular applications were also briefly proposed.

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“…The increasing demand for biodegradable implants in aseptic medical surgeries has led to the introduction of completely degradable materials to eliminate the need for the secondary surgical removal of permanent implants when they are no longer necessary [1][2][3][4]. Biodegradable implant materials should meet the following conditions [5][6][7][8][9][10]. Firstly, they should have good biocompatibility with human tissues, with good bioactivity during implementation and degradation processes, i.e., degradation products must not harm the human body and should not affect normal metabolic activities.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, this key problem might be solved by a zinc-based alloy. Moreover, Zn is an essential trace element required for the human body and plays a vital role in basic biological functions, such as collagen synthesis and osteoblast activity [7,8]. In addition, Zn has antimicrobial and biological properties that considerably reduce the risk of postoperative infection [11] Therefore, the development of degradable Zn for internal fracture fixation, vascular stents, and other implanted medical devices has good prospect.…”

Section: Introductionmentioning

confidence: 99%

Corrosion and Biocompatibility of Pure Zn with a Micro-Arc-Oxidized Layer Coated with Calcium Phosphate

et al. 2021

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Recent studies have indicated a great demand to optimize the biocompatibility properties of pure Zn as an implant material. For this purpose, CaZn2(PO4)2·2H2O (CaZnP) was prepared using hydrothermal treatment (HT) combined with micro-arc oxidation (MAO) on pure Zn substrate to generate biodegradable implants. The polarization test and electrochemical impedance spectroscopy indicated that the MAO1−HT coating could modulate the corrosion behavior of MAO1 by filling the crevice between the coating and the substrate. Immersion test evaluation revealed that the osteogenic properties of MAO1−HT coating were better than that of pure Zn substrate, as evidenced by the molar ratio of Ca and P, which increased after soaking in simulated body fluid (SBF) for up to 10 days. In addition, L-929 cells cultured in the 100%, 50%, and 25% extracts of MAO1−HT coated samples exhibited excellent cytocompatibility. Meanwhile, cell adhesion was promoted on the surface with high roughness generated during MAO and HT processes. In summary, the calcified coatings improved biocompatibility and adjusted the degradation rates of pure Zn, broadening the application of Zn alloys.

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Biodegradable ternary Zn–3Ge–0.5X (X=Cu, Mg, and Fe) alloys for orthopedic applications

Cited by 50 publications

References 64 publications

Rivet-Inspired Modification of Carbon Nanotubes by In Situ-Reduced Ag Nanoparticles To Enhance the Strength and Ductility of Zn Implants

Rivet-Inspired Modification of Carbon Nanotubes by In Situ-Reduced Ag Nanoparticles To Enhance the Strength and Ductility of Zn Implants

A review on current research status of the surface modification of Zn-based biodegradable metals

Corrosion and Biocompatibility of Pure Zn with a Micro-Arc-Oxidized Layer Coated with Calcium Phosphate

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