Biodegradable Temporising Matrix (BTM) for the reconstruction of defects following serial debridement for necrotising fasciitis: A case series

Wagstaff, Marcus J. D.; Salna, Ingrid; Caplash, Yugesh; Greenwood, John E.

doi:10.1016/j.burnso.2018.10.002

Cited by 39 publications

(37 citation statements)

References 14 publications

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“…Moreover, the authors demonstrated that the BTM continued to integrate into the wound bed following drainage of infected collections through perforations in the seal. This, in turn, resulted in improved healing of those deep and extensive wounds [ 105 , 106 ]. In addition, the BTM has been also used for the reconstruction of soft tissue defects, such as on the anterior neck, lateral chest and flank, and knee from mid-thigh to distal leg [ 106 ].…”

Section: Applications Of Hydrogels For Wound Healingmentioning

confidence: 99%

Advanced Hydrogels as Wound Dressings

2020

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Skin is the largest organ of the human body, protecting it against the external environment. Despite high self-regeneration potential, severe skin defects will not heal spontaneously and need to be covered by skin substitutes. Tremendous progress has been made in the field of skin tissue engineering, in recent years, to develop new skin substitutes. Among them, hydrogels are one of the candidates with most potential to mimic the native skin microenvironment, due to their porous and hydrated molecular structure. They can be applied as a permanent or temporary dressing for different wounds to support the regeneration and healing of the injured epidermis, dermis, or both. Based on the material used for their fabrication, hydrogels can be subdivided into two main groups—natural and synthetic. Moreover, hydrogels can be reinforced by incorporating nanoparticles to obtain “in situ” hybrid hydrogels, showing superior properties and tailored functionality. In addition, different sensors can be embedded in hydrogel wound dressings to provide real-time information about the wound environment. This review focuses on the most recent developments in the field of hydrogel-based skin substitutes for skin replacement. In particular, we discuss the synthesis, fabrication, and biomedical application of novel “smart” hydrogels.

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Section: Applications Of Hydrogels For Wound Healingmentioning

confidence: 99%

Advanced Hydrogels as Wound Dressings

2020

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“…This case is published in isolation to illustrate a particular finding (tendon gliding under the material despite lack of paratenon), and readers should reference our previous work for other examples of outcome. 1–3,10 BTM is regulated in the United States under an FDA 510(k) (a regulatory pathway granted by the US Food and Drug Administration prior to a company commercialising its product, where evidence that the medical device intended to be marketed is safe and effective) for use in wounds (excluding deep burns) and can be used now by US surgeons for similar indications. It is fully regulated for use in any wound in Australia and is also available in South Africa, India, Saudi Arabia, and Israel.…”

Section: Discussionmentioning

confidence: 99%

“…1 The observed ability of BTM to resist infection and ability to integrate into large wound beds 2 prompted its use in the reconstruction of postdebridement necrotising fasciitis defects. 3…”

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confidence: 99%

A Synthetic Biodegradable Temporising Matrix in Degloving Lower Extremity Trauma Reconstruction: A Case Report

Damkat-Thomas

Greenwood

Wagstaff

2019

Plastic and Reconstructive Surgery - Global Open

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“…Growing environmental pollution has forced the development of biodegradable polymers and, at the start of this millennium, Thilak Gunitillake at the Commonwealth Scientific, Industrial and Research Organisation (CSIRO) in Melbourne, Australia developed a family of biodegradable polyurethanes, now called NovoSorb. 1 A completely synthetic, biodegradable polyurethane dermal matrix was designed and developed in Adelaide and is progressively becoming more available: the NovoSorb TM Biodegradable Temporising Matrix (BTM), 1,[11][12][13][14][15][16][17][18][19][20][21][22][23] produced by PolyNovo Biomaterials Pty Ltd, Port Melbourne, Victoria, Australia.…”

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confidence: 99%

“…Thus, infection is uncommon and, if it does occur, is localised and manageable without loss of the matrix. 16,22,23 Increasing burns use also demonstrated that loss of skin graft over the integrated BTM is extremely rare and that the appearance of autograft mesh pattern (even with widely meshed graft) is considerably better than autograft alone. 22 This finding has also been observed with collagen-based matrices and has its basis in the principles of wound healing.…”

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confidence: 99%

A paradigm shift in practice—the benefits of early active wound temporisation rather than early skin grafting after burn eschar excision

Greenwood

2020

Anaesth Intensive Care

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After major burn injury, once survival is achieved by the immediate excision of all deep burn eschar, we are faced with a patient who is often physiologically well but with very extensive wounds. While very early grafting yields excellent results after the excision of small burns, it is not possible to achieve the same results once the wound size exceeds the available donor site. In patients where 50%–100% of the total body surface area is wound, we rely on serial skin graft harvest, from finite donor site resources, and the massive expansion of those harvested grafts to effect healing. The result is frequently disabling and dysaesthetic. Temporisation of the wounds both passively, with cadaver allograft, and actively, with dermal scaffolds, has been successfully employed to ameliorate some of the problems caused by our inability to definitively close wounds early. Recent advances in technology have demonstrated that superior functional and cosmetic outcomes can be achieved in actively temporised areas even when compared with definitive early closure with skin graft. This has several beneficial implications for both patient and surgeon, affecting the timing of definitive wound closure and creating a paradigm shift in the care of the burned patient.

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Biodegradable Temporising Matrix (BTM) for the reconstruction of defects following serial debridement for necrotising fasciitis: A case series

Cited by 39 publications

References 14 publications

Advanced Hydrogels as Wound Dressings

Advanced Hydrogels as Wound Dressings

A Synthetic Biodegradable Temporising Matrix in Degloving Lower Extremity Trauma Reconstruction: A Case Report

A paradigm shift in practice—the benefits of early active wound temporisation rather than early skin grafting after burn eschar excision

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