Biodegradable stents in gastrointestinal endoscopy

Lorenzo-Zúñiga, Vicente; Moreno-de-Vega, Vicente; Marín, Íngrid; Boix, Jaume

doi:10.3748/wjg.v20.i9.2212

Cited by 58 publications

(54 citation statements)

References 40 publications

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“…The technical and clinical success rate is as high as 100%, but initial enthusiasm has been dampened because two thirds of the patients had major complications, such as stent migration and fistula formation leading to perforations 133 . One alternate solution to these complications is the use of biodegradable stents, but there have been only a small number of reports on this approach 134 . Stent integrity and radial force are maintained for 6–8 weeks and disintegration occurs around 12 weeks after implantation.…”

Section: Management Of Fibrostenosing Ibdmentioning

confidence: 99%

Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases

2017

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In the last 10 years, we have learned much about the pathogenesis, diagnosis, and management of intestinal fibrosis in patients with inflammatory bowel diseases (IBD). Just a decade ago, intestinal strictures were considered to be an inevitable consequence of long-term inflammation in patients who did not respond to anti-inflammatory therapies. IBD-associated fibrosis was seen as an irreversible process that frequently led to intestinal obstructions requiring surgical intervention. This paradigm has changed rapidly, due to the anti-fibrotic approaches that may become available. We review the mechanisms and diagnosis of this serious complication of IBD, as well as factors that predict its progression and management strategies.

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Section: Management Of Fibrostenosing Ibdmentioning

confidence: 99%

Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases

2017

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“…PDX stents seem to be an attractive alternative to repeated dilations or surgery in patients with benign stenoses of the esophagus and of the small and large intestines. PDX stents have shown promising results but some aspects of this material/these stents need further improvement such as the loss of radial force over time due to the degradable material, which can induce mucosal or parenchymal injuries [28]. These issues in addition to a modest clinical efficacy have allowed limited indications of BD stents in gastroenterology [28].…”

Section: Discussionmentioning

confidence: 99%

“…This seems surprising in comparison with other medical specialties such as cardiology in which stents made of different BD materials have been successfully tested in coronary artery diseases. In a recent review [23] the majority of the published studies have tested PLLA or PLGA BD stents activated with anti-proliferative agents and nonpolymeric BD stents such as stents made of magnesium [28]. BD stents have been largely investigated in humans for the treatment of diverse gastrointestinal diseases.…”

Section: Discussionmentioning

confidence: 99%

“…BD stents have been largely investigated in humans for the treatment of diverse gastrointestinal diseases. The vast majority of these stents used PDS as the BD material [28]. PDX stents seem to be an attractive alternative to repeated dilations or surgery in patients with benign stenoses of the esophagus and of the small and large intestines.…”

Section: Discussionmentioning

confidence: 99%

“…Sutures for a healing wound or fixation devices for a broken bone [14] would be examples of the corresponding support devices. Tubular degradable stents have been manufactured for the treatment including various vascular (mainly coronary diseases) [15,16,17,18,19,20,21,22,23] and esophageal or bile duct [24,25,26,27,28] conditions as well as urethral [29,30] strictures and have already been tested in animals and humans.…”

Section: Research and Medical Applications Of Degradable Biomaterialsmentioning

confidence: 99%

See 2 more Smart Citations

Biodegradable Airway Stents - Bench to Bedside: A Comprehensive Review

Dutau¹,

Musani

Laroumagne³

et al. 2015

Respiration

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Airway stents are indicated to treat symptomatic narrowing or to close fistulas of the central airways. They are generally divided into two types: the silicone stents and the metallic stents. Unlike in malignancies, removability is a major objective of temporary stenting in benign conditions, which poses the challenge of a new rigid bronchoscopic procedure under general anesthesia and stent removal with all its attendant risks and costs. The concept of a biodegradable (BD) stent that could maintain the patency of an airway for a predetermined duration of time is very appealing. These BD stents would gradually degrade and eventually vanish from the airway once they are no longer needed. Such stents are currently an area of intense research. Another very promising concept of drug delivery with such stents is also a very exciting area of current research. The aim of this comprehensive review is to discuss all pertinent available literature on the use of BD materials in various clinical applications and to extensively review all animal and humans trials involving BD airway stents.

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A novel braided biodegradable stent for use in congenital heart disease: Short‐term results in porcine iliac artery

Sun

Kim

Bai

et al. 2019

J Biomedical Materials Res

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To evaluate the properties and efficacy of a novel braided biodegradable stent (BBS) consisting of poly (p‐dioxanone) (PPDO) and polycaprolactone (PCL) for usage in children with congenital cardiovascular diseases. PCL/PPDO composite filaments were fabricated by coating PCL layers onto PPDO filaments, which were fused with PPDO monofilaments to form the BBS. Physical properties of BBSs including elastic recovery rate, deformation rate, and mechanical characteristics with adjunctive post‐dilation were evaluated by radial force‐tests. Ten BBS stents and 10 metallic wall stents (WS) as controls were implanted into the common carotid arteries of 10 pigs and angiography as well as histological examinations were performed 4 and 8 weeks after implantation. An 8 mm BBS with adjunctive post‐dilation had the best morphological retention and dimension stability being similar to an 8 mm WS. Luminal gain percentages of BBS and WS immediately, 4 weeks and 8 weeks after implantation were 20.44 ± 2.82% and 27.08 ± 0.88%, 12.34 ± 0.18% and 17.32 ± 8.24%, as well as −1.76 ± 2.45% and − 0.98 ± 3.23%. Luminal areas, internal elastic laminas, neointimal areas, neointimal thicknesses, and area stenosis were not significantly different at 4 weeks and 8 weeks after implantation. Injury and inflammation were similar in both groups and no malposition, thrombosis or dissection occurred. BBS with adjunctive post‐dilation showed good physical properties and mechanical stability noninferior to WS. In vivo evaluations showed that a BBS with post‐ballooning had similar short‐term outcomes as a WS. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1667–1677, 2019.

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Biodegradable stents in gastrointestinal endoscopy

Cited by 58 publications

References 40 publications

Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases

Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases

Biodegradable Airway Stents - Bench to Bedside: A Comprehensive Review

A novel braided biodegradable stent for use in congenital heart disease: Short‐term results in porcine iliac artery

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