Biodegradable Silk Fibroin Matrices for Wound Closure in a Human 3D Ex Vivo Approach
Jan Tinson Strenge,
Ralf Smeets,
Fateme Nemati
et al.
Abstract:In this study, the potential of silk fibroin biomaterials for enhancing wound healing is explored, focusing on their integration into a human 3D ex vivo wound model derived from abdominoplasties. For this purpose, cast silk fibroin membranes and electrospun nonwoven matrices from Bombyx mori silk cocoons were compared to untreated controls over 20 days. Keratinocyte behavior and wound healing were analyzed qualitatively and quantitatively by histomorphometric and immune histochemical methods (HE, Ki67, TUNEL).… Show more
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