Biodegradable reduction and pH dual-sensitive polymer micelles based on poly(2-ethyl-2-oxazoline) for efficient delivery of curcumin

Abstract

<p>A series of disulfide-linked amphiphilic polymers polyoxaline-SS-poly(lactide) (PEtOx-SS-PLA) were prepared and self-assembled into nano-micelles in water.</p>

Inhaled ciprofloxacin-loaded poly(2-ethyl-2-oxazoline) nanoparticles from dry powder inhaler formulation for the potential treatment of lower respiratory tract infections

“…Moreover, PEtOx with two-pseudo peptides has drawn attention as an alternative to PEG with altered stability against oxidative degradation [ 17 ]. Recently, Zhang et al [ 18 ] formulated curcumin-loaded PEtOx-polylactic acid nano-micelles for effective delivery of curcumin and found the enhanced release of the drug from the micelles with increased inhibition effect on cancer cells. Doxorubicin-loaded polyurethane-PEtOx micelles provided a rapid release of the drug by complete disassembly of the micelles.…”

NLRP3 Inflammasome-Targeting Nanomicelles for Preventing Ischemia–Reperfusion-Induced Inflammatory Injury

“…The pH-sensitive nature of the nanomicelles was due to the acid-sensitive amide bond which is a characteristic bond present in POx of PMPL . We also studied the in vitro drug release behavior of M-PMPL@Tf nanomicelles in different pH conditions by the dialysis bag method (Figure B).…”

“…The pH-sensitive nature of the nanomicelles was due to the acid-sensitive amide bond which is a characteristic bond present in POx of PMPL. 9 We also studied the in vitro drug release behavior of M-PMPL@Tf nanomicelles in different pH conditions by the dialysis bag method (Figure 3B). We observed that at a pH of 7.4, the maximum MCC950 release observed was 29% until 98 h. However, burst release of 38% was observed after 8 h, which was sustained and continued up to 93% and 84%, respectively, at pH 6.0 and pH 6.5, which was a nonsignificant difference.…”

“…A growing body of evidence suggests that I/R triggers a significant nonpathogenic inflammatory response that can result in tissue damage. − Inflammasomes, which are multiprotein intracellular complexes that respond to a range of stimuli, have recently been identified as the key effector component of the inflammatory response. , The NOD-like receptor (NLR) family, specifically the pyrin domain-containing protein 3 (NLRP3) inflammasome, plays an important role in sterile inflammation following I/R injury. − When cytosolic pattern recognition receptors recognize damage-associated molecular patterns (DAMPs), the inflammasome complex recruits and activates caspase 1, which then cleaves downstream inflammatory components into active forms, such as pro-interleukin-1β (pro-IL-1β) and pro-IL-18 . Extracellular production of IL-1β and IL-18 trigger immune processes.…”

Stability of Inhaled Ciprofloxacin-Loaded Poly(2-ethyl-2-oxazoline) Nanoparticle Dry Powder Inhaler Formulation in High Stressed Conditions

“…It is a non-ionic polymer attractive for drug delivery because of its unique characteristics including high solubility in water and polar organic solvents, non-toxic behaviour, and high thermal stability [ 21 ]. Additionally, PEtOx is known to demonstrate pH-responsive drug release characteristics in biomedical applications [ 22 ]. Moreover, PEtOx NPs demonstrated significantly lower non-specific cellular uptakes compared to poly(ethylene glycol) (PEG) NPs with improved stealth modification of the surface properties of the NPs [ 23 ].…”