Biodegradable porous FeMn(–<i>x</i>Ag) alloys: assessment of cytocompatibility, mechanical, magnetic and antibiofilm properties

Bartkowska, Aleksandra; Careta, Oriol; Turner, Adam Benedict; Blanquer, Andreu; Ibáñez, Elena; Trobos, Margarita; Nogués, Carme; Pellicer, Eva; Sort, Jordi

doi:10.1039/d2ma00867j

Cited by 6 publications

(4 citation statements)

References 72 publications

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“…No undissolved Si-rich precipitates can be observed after hot rolling treatment in the microstructure as in other FeMnSi SMA. Compared to FeMn alloy, the addition of Si resulted in a better recrystallization treatment, resulting in a more homogenized microstructure with an average grain size of 40 µm ± 5 µm (mean value and standard deviation) [54]. Similar to other results in the literature, silver separation was observed based on the very low solubility of silver in the solid solution of iron-manganese [55,56].…”

Section: Microstructural (Sem) and Chemical (Eds And Xrd) Analysissupporting

confidence: 77%

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Influence of Dynamic Strain Sweep on the Degradation Behavior of FeMnSi–Ag Shape Memory Alloys

Roman

Cimpoeșu

Pricop

et al. 2023

JFB

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Iron-based SMAs can be used in the medical field for both their shape memory effect (SME) and biodegradability after a specific period, solving complicated chirurgical problems that are partially now addressed with shape-memory polymers or biodegradable polymers. Iron-based materials with (28–32 wt %) Mn and (4–6 wt %) Si with the addition of 1 and 2 wt % Ag were obtained using levitation induction melting equipment. Addition of silver to the FeMnSi alloy was proposed in order to enhance its antiseptic property. Structural and chemical composition analyses of the newly obtained alloys were performed by X-ray diffraction (confirming the presence of ε phase), scanning electron microscopy (SEM) and energy-dispersive spectroscopy. The corrosion resistance was evaluated through immersion tests and electrolyte pH solution variation. Dynamic mechanical solicitations were performed with amplitude sweep performed on the FeMnSi–1Ag and FeMnSi–2Ag samples, including five deformation cycles at 40 °C, with a frequency of 1 Hz, 5 Hz and 20 Hz. These experiments were meant to simulate the usual behavior of some metallic implants subjected to repetitive mechanical loading. Atomic force microscopy was used to analyze the surface roughness before and after the dynamic mechanical analysis test followed by the characterization of the surface profile change by varying dynamic mechanical stress. Differential scanning calorimetry was performed in order to analyze the thermal behavior of the material in the range of −50–+200 °C. X-ray diffraction and Fourier transform infrared spectroscopy (FTIR) along with Neaspec nano-FTIR experiments were performed to identify and confirm the corrosion compounds (oxides, hydroxides or carbonates) formed on the surface.

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Section: Microstructural (Sem) and Chemical (Eds And Xrd) Analysissupporting

confidence: 77%

“…FeMnSi-1Ag and FeMnSi-2Ag have a complex microstructure consisting of γ-austenite (fcc structure) and ε-martensite (hcp structure) at room temperature. Small plate-like εmartensite zones can be observed on the FeMnSi-2Ag alloy structure (Figure 1b) [54].…”

Section: Microstructural (Sem) and Chemical (Eds And Xrd) Analysismentioning

confidence: 99%

Influence of Dynamic Strain Sweep on the Degradation Behavior of FeMnSi–Ag Shape Memory Alloys

Roman

Cimpoeșu

Pricop

et al. 2023

JFB

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“…coli, − S. aureus, , or both strains as well as various staphylococci strains . Therefore, FeMnC-based alloys were evaluated for the first time regarding their antibacterial behavior against P.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the bacterial attachment and biofilm formation of three different bacteria strains on biodegradable FeMnC-based alloys was evaluated for the first time in comparison with corrosion-resistant 316L stainless steel. Studies investigating the antibacterial effect of Cu or Ag in Fe-based alloys, considered only one bacteria strain for their testing, either E. coli , 33 − 36 S. aureus, 37 , 56 or both strains 57 as well as various staphylococci strains. 58 Therefore, FeMnC-based alloys were evaluated for the first time regarding their antibacterial behavior against P. aeruginosa in this study.…”

Section: Discussionmentioning

confidence: 99%

Inherent Antibacterial Properties of Biodegradable FeMnC(Cu) Alloys for Implant Application

Paul,

Kiel,

Otto

et al. 2024

ACS Appl. Bio Mater.

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Implant-related infections or inflammation are one of the main reasons for implant failure. Therefore, different concepts for prevention are needed, which strongly promote the development and validation of improved material designs. Besides modifying the implant surface by, for example, antibacterial coatings (also implying drugs) for deterring or eliminating harmful bacteria, it is a highly promising strategy to prevent such implant infections by antibacterial substrate materials. In this work, the inherent antibacterial behavior of the as-cast biodegradable Fe69Mn30C1 (FeMnC) alloy against Gram-negative Pseudomonas aeruginosa and Escherichia coli as well as Gram-positive Staphylococcus aureus is presented for the first time in comparison to the clinically applied, corrosion-resistant AISI 316L stainless steel. In the second step, 3.5 wt % Cu was added to the FeMnC reference alloy, and the microbial corrosion as well as the proliferation of the investigated bacterial strains is further strongly influenced. This leads for instance to enhanced antibacterial activity of the Cu-modified FeMnC-based alloy against the very aggressive, wild-type bacteria P. aeruginosa. For clarification of the bacterial test results, additional analyses were applied regarding the microstructure and elemental distribution as well as the initial corrosion behavior of the alloys. This was electrochemically investigated by a potentiodynamic polarization test. The initial degraded surface after immersion were analyzed by glow discharge optical emission spectrometry and transmission electron microscopy combined with energy-dispersive X-ray analysis, revealing an increase of degradation due to Cu alloying. Due to their antibacterial behavior, both investigated FeMnC-based alloys in this study are attractive as a temporary implant material.

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Degradation behavior of austenite, ferrite, and martensite present in biodegradable Fe-based alloys in three protein-rich pseudo-physiological solutions

Cherqaoui,

Cao,

Gatto

et al. 2024

Bioactive Materials

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Biodegradable porous FeMn(–xAg) alloys: assessment of cytocompatibility, mechanical, magnetic and antibiofilm properties

Abstract: In this work, porous FeMn(-xAg) alloys are fabricated through powder metallurgy methods. The effects of porosity and Ag addition on the microstructure, biodegradability, magnetic and mechanical properties of the alloys...

Cited by 6 publications

References 72 publications

Influence of Dynamic Strain Sweep on the Degradation Behavior of FeMnSi–Ag Shape Memory Alloys

Influence of Dynamic Strain Sweep on the Degradation Behavior of FeMnSi–Ag Shape Memory Alloys

Inherent Antibacterial Properties of Biodegradable FeMnC(Cu) Alloys for Implant Application

Degradation behavior of austenite, ferrite, and martensite present in biodegradable Fe-based alloys in three protein-rich pseudo-physiological solutions

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