Biodegradable polymers for the sustained release of peptides

Hutchinson, F.; Furr, B. J. A.

doi:10.1042/bst0130520

Cited by 99 publications

(37 citation statements)

References 3 publications

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“…[15][16][17][18] Evidence of internal erosion and increased porosity of microcapsules was seen in the SEM micrographs. Loss of molecular weight (Fig.…”

Section: Discussionmentioning

confidence: 99%

Effect of particle size on the in vitro and in vivo degradation rates of poly(DL‐lactide‐co‐glycolide) microcapsules

Visscher¹,

Pearson²,

Fong³

et al. 1988

J. Biomed. Mater. Res.

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Three different sieve size fractions of ergot-containing biodegradable microcapsules were examined both in vitro and in vivo. The sieve sizes and average particle diameter, (micron), were: less than 45-75 (mean = 30); 75-106 (mean = 79); 106-177 (mean = 130). These microcapsules contained ca. 9% drug and were produced from 50:50 poly(DL-lactide-co-glycolide). The objective was to determine the effect of particle size on in vivo and in vitro degradation rates. The microcapsules were injected into rat gastrocnemius muscle and excised and examined at various time points up to 70 days. Initially a minimal tissue response was noted which was characterized by a sharply localized acute inflammatory reaction. Following this, connective tissue and foreign body giant cells engulfed the microcapsules at 20-30 days. Only vestiges of the microcapsules were found surrounded by minimal connective tissue and foreign body giant cells after 60-70 days. The tissue reaction was a minimal, sharply localized foreign body giant cell and connective tissue process for all three size groups of microcapsules. The largest microcapsules (mean = 130 microns) exhibited a slightly greater tendency to undergo in vivo and in vitro degradation relative to the other groups. However, it can be concluded that over the microcapsule size ranges examined minimal differences in the degradation properties of the polymeric matrices and consequently those of the microcapsules were noted.

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“…[15][16][17][18] Evidence of internal erosion and increased porosity of microcapsules was seen in the SEM micrographs. Loss of molecular weight (Fig.…”

Section: Discussionmentioning

confidence: 99%

Effect of particle size on the in vitro and in vivo degradation rates of poly(DL‐lactide‐co‐glycolide) microcapsules

Visscher¹,

Pearson²,

Fong³

et al. 1988

J. Biomed. Mater. Res.

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show abstract

“…The rod had dimensions of approximately 1.5 mm diameter and 1.8 cm length. The co-polymer degrades in the body to naturally occurring glycolic and lactic acids, which are then metabolized completely [10], Serum LH, testosterone and Zoladex concentrations (as part of the pharmacokinetic study) as well as routine hematology and biochemis try were monitored on day 1 (pretreatment), days 2.3. 5, 8 and weekly thereafter until serum testosterone levels reached values at least twice the upper limit of the surgically-castrate range (2 nmol/1) on 2 consec utive measurements.…”

Section: Methodsmentioning

confidence: 99%

A New Longer-Acting LHRH Analog Depot: Preliminary Results of a Dutch Open Phase II Clinical Study on a 10.8 mg Zoladex 3-Monthly Depot

Dijkman

Moral²,

Plasman³

et al. 1990

Eur Urol

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“…In view of the continuing interest in the concept of 'total androgen withdrawal' [8, 9j, a comparison was made of the effects of treatment with single subcuta neous biodegradable depots containing 1 mg of the LHRH agonist Zoladex [47] given every 28 days, daily oral administration of Casodex (25 mg/kg) and a combi nation of the two therapies in rats bearing Dunning prostate tumours. The results are shown in figure 9 and clearly indicate that both Zoladex and Casodex treatment alone are as effective as surgical castration at inhibiting the growth rate of these prostate tumours.…”

Section: Effects Of Casodex On Accessory Sex Organs In Adult Male Monmentioning

confidence: 99%

The Development of Casodex™ (Bicalutamide): Preclinical Studies

Furr¹

1996

Eur Urol

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Biodegradable polymers for the sustained release of peptides

Cited by 99 publications

References 3 publications

Effect of particle size on the in vitro and in vivo degradation rates of poly(DL‐lactide‐co‐glycolide) microcapsules

Effect of particle size on the in vitro and in vivo degradation rates of poly(DL‐lactide‐co‐glycolide) microcapsules

A New Longer-Acting LHRH Analog Depot: Preliminary Results of a Dutch Open Phase II Clinical Study on a 10.8 mg Zoladex 3-Monthly Depot

The Development of Casodex™ (Bicalutamide): Preclinical Studies

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