2022
DOI: 10.2174/1389201022666210708105142
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Biodegradable Polymers-based Nanoparticles to Enhance the Antifungal Efficacy of Fluconazole against Candida albicans

Abstract: Background: Fluconazole (FLZ), a potent antifungal medication, is characterized by poor water solubility that reduced its antifungal efficacy. Objective: This study aimed to prepare FLZ-loaded polymeric nanoparticles (NPs) by using different polymers and techniques as a mean of enhancing the antifungal activity of FLZ. Methods: NP1, NP2, and NP3 were prepared by the double emulsion/solvent evaporation method using PLGA, PCL, and PLA, respectively. The ionotropic pre-gelation technique was applied to prep… Show more

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Cited by 6 publications
(2 citation statements)
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“…A marked inhibition zone of about 28 mm was observed with the optimized nanoformulation. The rationale for this finding is the improvement in drug diffusion from the drug-loaded PCL nanoparticles which enhanced the drug antifungal activity as previously mentioned for FLZ-loaded alginate/chitosan-based polymeric nanoparticles against Candida albicans [ 43 ].…”
Section: Resultsmentioning
confidence: 99%
“…A marked inhibition zone of about 28 mm was observed with the optimized nanoformulation. The rationale for this finding is the improvement in drug diffusion from the drug-loaded PCL nanoparticles which enhanced the drug antifungal activity as previously mentioned for FLZ-loaded alginate/chitosan-based polymeric nanoparticles against Candida albicans [ 43 ].…”
Section: Resultsmentioning
confidence: 99%
“…, suggesting MTX molecules were loaded in/on the polymeric matrix [77] and negating interaction between MTX and NPs ingredients [67]. Moreover, the spectra of F10 and its plain NPs showed the characteristic band of FA-CS at 3451 cm -1…”
Section: Fourier Transform Infrared Spectroscopy (Ftir)mentioning
confidence: 99%