Biodegradable Polymers as Scaffolds for Tissue Engineering

Ikada, Yoshito

doi:10.1002/9783527635818.ch14

Cited by 7 publications

(5 citation statements)

References 19 publications

(16 reference statements)

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“…The materials used with the electrospun technique possess unique characteristics such as a higher surface area to volume ratios, have improved cellular interactions, and better protein absorption, and thus the enhanced absorption that leads to good binding sites and enhanced cells reception [120,205]. Others found that the use of various flexible biodegradable polymers (for example, PEG (poly (ethylene glycol), as well as polyesters including polycaprolactone (PCL), poly (D,L-lactide-co-glycolide) (PLGA), poly(glycolic acid) (PGA), poly(lactic acid) (PLA), as well their copolymers), as scaffolds (nanofibrous scaffolds) increases enhances regeneration of dental tissues [53,206,207].Furthermore, Kim et al, [208] found that nano-structured implants improved dental restoration and regeneration efficiencies as a result of the structural similarities to that of an ECM (natural extracellular matrix).…”

Section: The Application Of Electrospun Nanofiber In Dental Fieldsmentioning

confidence: 99%

Injectable Biomaterials for Dental Tissue Regeneration

Haugen

Basu

Sukul

et al. 2020

IJMS

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Injectable biomaterials scaffolds play a pivotal role for dental tissue regeneration, as such materials are highly applicable in the dental field, particularly when compared to pre-formed scaffolds. The defects in the maxilla-oral area are normally small, confined and sometimes hard to access. This narrative review describes different types of biomaterials for dental tissue regeneration, and also discusses the potential use of nanofibers for dental tissues. Various studies suggest that tissue engineering approaches involving the use of injectable biomaterials have the potential of restoring not only dental tissue function but also their biological purposes.

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Section: The Application Of Electrospun Nanofiber In Dental Fieldsmentioning

confidence: 99%

Injectable Biomaterials for Dental Tissue Regeneration

Haugen

Basu

Sukul

et al. 2020

IJMS

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“…2–4 Due to inherent properties of brittleness, bioceramics have been incorporated with polymeric network, resulting in increasing some degree of dental regeneration. 5,6…”

Section: Introductionmentioning

confidence: 99%

Microwave-assisted synthesis and evaluation of type 1 collagen–apatite composites for dental tissue regeneration

et al. 2018

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The aim was to develop an economical and biocompatible collagen-based bioactive composite for tooth regeneration. Acid-soluble collagen was extracted and purified from fish scales. The design was innovated to molecularly tailor the surface charge sites of the nano-apatite providing chemical bonds with the collagen matrix via microwave irradiation technique. The obtained collagen was identified by sodium dodecyl sulfate polyacrylamide gel electrophoresis analysis. The composites were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis/differential scanning calorimetry, and scanning electron microscopy. MC3T3-E1 cell lines were used to assess the biological effects of these materials by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetra zolium bromide (MTT) assay. Indirect contact test was performed by extracting representative elutes in cell culture media and sulforhodamine B analysis was performed. Chorioallantoic membrane assay was conducted to define the new vessels formation behavior. The purity of collagen extracts was determined and showed two α-chains, i.e. the characteristic of type I collagen. Fourier transform infrared spectroscopy showed the characteristic peaks for amide I, I, III, and phosphate for collagen and composites. Scanning electron microscopy images showed three-dimensional mesh of collagen/apatite nano-fibers. Nontoxic behavior of composites was observed and there were graded and dose-related effects on experimental compounds. The angiogenesis and vessels formation behavior were observed in bioactive collagen composite. The obtained composites have potential to be used for tooth structure regeneration.

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“…Biodegradable polymers are an increasing percentage of the global plastic production . They have many uses in biomedical devices and disposable utensils. − However, replacing petroleum-derived polymers remains a challenge because of the wide range of applications that traditional plastics have. In order to expand the physical properties of biodegradable polymers, one can incorporate blocks of other polymers to make block copolymers.…”

Section: Introductionmentioning

confidence: 99%

Mechanistic Studies of Redox-Switchable Copolymerization of Lactide and Cyclohexene Oxide by a Zirconium Complex

2017

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Several aspects of the copolymerization of L-lactide (LA) and cyclohexene oxide (CHO) by a redox switchable zirconium catalyst, (salfan)Zr(O t Bu)2 (salfan = 1,1'-di(2-tert-butyl-6-N-methylmethylenephenoxy)ferrocene), were examined such as the mechanism of cyclohexene oxide polymerization, the reactivity of [(salfan)Zr(O t Bu)2][BAr F ] (BAr F = tetrakis(3,5-bis(trifluoromethyl)phenyl)borate) toward lactide, and co-monomer effects on polymerization rates. Experimental methods and DFT calculations indicate that the likely mechanism of CHO polymerization by [(salfan)Zr(O t Bu)2][BAr F ] is coordination insertion and not a cationic pathway, as employed by the majority of cationic catalysts. Furthermore, DFT calculations showed that the polymerization of LA by [(salfan)Zr(O t Bu)2][BAr F ] is not thermodynamically favored, in agreement with experimental results. Lastly, we found that the conversion times of CHO or LA from block to block correlate with the amount of monomer left from the previous block rather than other factors.

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Biodegradable Polymers as Scaffolds for Tissue Engineering

Cited by 7 publications

References 19 publications

Injectable Biomaterials for Dental Tissue Regeneration

Injectable Biomaterials for Dental Tissue Regeneration

Microwave-assisted synthesis and evaluation of type 1 collagen–apatite composites for dental tissue regeneration

Mechanistic Studies of Redox-Switchable Copolymerization of Lactide and Cyclohexene Oxide by a Zirconium Complex

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