Biodegradable polymeric vesicles containing magnetic nanoparticles, quantum dots and anticancer drugs for drug delivery and imaging

Ye, Fei; Barrefelt, Åsa; Asem, Heba; Abedi‐Valugerdi, Manuchehr; El-Serafi, Ibrahim; Saghafian, Maryam; Abu‐Salah, Khalid M.; Alrokayan, Salman A.; Muhammed, Mamoun; Hassan, Manal M.

doi:10.1016/j.biomaterials.2014.01.041

Cited by 205 publications

(138 citation statements)

References 43 publications

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“…Polymeric nanocarriers have been fabricated from natural and synthetic polymers. [15] Natural polymers, such as chitosan, dextran and hyaluronic acid, are viable candidates for biomedical applications because of their outstanding biocompatibility; however, synthetic polymers are more widely studied because the chemical and physical properties of synthetic polymers can be more precisely tuned.…”

Section: Combination Therapymentioning

confidence: 99%

Co‐Delivery of Drugs and Genes Using Polymeric Nanoparticles for Synergistic Cancer Therapeutic Effects

Thambi

Lee

2017

Adv Healthcare Materials

103

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Drug and gene delivery systems based on nanoparticles, microparticles and hydrogels have been widely studied for cancer treatment in the past decade. To achieve an efficient and safe delivery, selection of drug and gene delivery carrier is critical. Biocompatible polymeric nanoparticles are considerably promising carrier candidates in delivery of drugs and genes because of their unique chemical and physical properties. However, delivery of a drug or gene sometimes cannot achieve a satisfactory treatment effect. Therefore, co‐delivery of dual drugs or co‐delivery of a drug and a gene in a polymeric nanoparticle has attracted attention. Such co‐delivery systems can overcome multi‐drug resistance of chemical drugs and achieve a synergistic therapeutic effect. In this progress report, we summarize recent progress in the preparation and application of polymeric drug and gene co‐delivery nanosystems. The remaining challenges and future trends in this field are also included.

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Section: Combination Therapymentioning

confidence: 99%

Co‐Delivery of Drugs and Genes Using Polymeric Nanoparticles for Synergistic Cancer Therapeutic Effects

Thambi

Lee

2017

Adv Healthcare Materials

103

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“…[5] Therefore, polymersomes are attractive candidates for various applications, including anticancer drug carriers, gene and siRNA vectors, and diagnostic imaging probes. [6][7][8] Recently, much attention has been focused on stimuliresponsive polymeric vesicles that can control the release of encapsulated agents by readily triggering a change in the polymersome membrane properties via an external stimulus, such as pH change, hydrolysis, redox, temperature variation, ionic strength, light, electrical potential, or multiple stimuli. [9][10][11][12][13] In particular, a pH-sensitive polymersome exhibits great potential for use in controlled release/encapsulation based on the wide range of pH gradients that are present in biological and physiological systems.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of pH‐Responsive Copolypeptides Vesicles for siRNA and Chemotherapeutic Drug Co‐Delivery

Huang

et al. 2015

Macromolecular Bioscience

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Novel diblock copolypeptides are synthesized and evaluated as a pH-sensitive drug delivery vector for anticancer drugs and siRNA co-delivery. The synthetic process involve the ring opening polymerization of α-amino acid N-carboxyanhydrides as well as aminolysis and deprotection reactions, and the structures are characterized. The copolypeptides can self-assemble into stable vesicles at neutral pH, and disassemble in acidic endosomal/lysosomal, which shown the pH-responsive behavior. The cell uptake results indicated that the vesicles can co-deliver DOX and siRNA inside the same cell and exhibit a pH-sensitive release behavior. Therefore, the novel polymeric vesicles are a promising carrier for co-delivery anticancer drug and siRNA to overcome the drug resistance and enhance cancer treatment.

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“…[15][16][17][18][19][20] In tumor tissues, the vascular walls have submicron holes because of rapid angiogenesis; therefore, nanocarriers can permeate into tumors through the vascular wall. Furthermore, the lymph system around tumors grows so slowly that nanocarriers are usually retained in the tumor.…”

Section: -14mentioning

confidence: 99%

Unsymmetric vesicles with a different design on each side for near-infrared fluorescence imaging of tumor tissues

et al. 2015

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Biodegradable polymeric vesicles containing magnetic nanoparticles, quantum dots and anticancer drugs for drug delivery and imaging

Cited by 205 publications

References 43 publications

Co‐Delivery of Drugs and Genes Using Polymeric Nanoparticles for Synergistic Cancer Therapeutic Effects

Co‐Delivery of Drugs and Genes Using Polymeric Nanoparticles for Synergistic Cancer Therapeutic Effects

Synthesis and Characterization of pH‐Responsive Copolypeptides Vesicles for siRNA and Chemotherapeutic Drug Co‐Delivery

Unsymmetric vesicles with a different design on each side for near-infrared fluorescence imaging of tumor tissues

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